Sentences with phrase «molt4 human leukemia»

A decade ago, he replicated the entire human leukemia disease process by introducing oncogenes into normal human blood cells, transplanting them into xenografts (special immune - deficient mice that accept human grafts) and watching leukemia develop — a motherlode discovery that has guided leukemia research ever since.

The study involved laboratory cell lines of human leukemia and mouse models of the disease.

«The bacterial enzyme killed about 90 % of the MOLT4 human leukemia cells and displayed low toxicity to the healthy HUVEC cells, killing only 10 %,» Monteiro said.

The researchers were able to identify the new molecular targets by conducting a global proteomic analysis of human leukemia cells.

When the mice received no treatment or were treated with imatinib alone, the human leukemia stem cells propagated and grew to relatively large numbers.

Its first target was the regulatory network involved in controlling the differentiation of THP - 1 cells, a line of human leukemia cells used in laboratory experiments.

Animal studies using mouse models for human leukemia and lymphoma have shown Leukothera ® to possess significant anti-cancer activity.

Interestingly, runx1 is also one of the most frequently mutated genes in human leukemias, supporting that runx1 plays an important role in the adult.

Gallo and his colleagues then opened and pioneered the field of human retrovirology with the discovery of the first human retrovirus (HTLV - 1) and along with Japanese investigators showed it was a cause of a particular form of human leukemia.

ABL tyrosine kinases play an oncogenic role in human leukemias (4, 5) and promote the progression of solid tumors (5, 6).

He notes that students are involved in every step of the research process — growing human leukemia cells, performing the experiments, analyzing the data that the experiments generate and interpreting those data as to what they're saying about the cells» genetic network.

Design and Methods Taking advantage of a model of spontaneous cellular transformation, we sequenced JAK1 in selected tumorigenic BaF3 clones and identified 25 de novo JAK1 activating mutations, including 5 mutations already described in human leukemias.

Lapotko D, Lukianova E, Оraevsky A. Selective laser nano - thermolysis of human leukemia cells with microbubbles generated around clusters of gold nanoparticles.

Vitamin K2 induces certain kinds of human leukemia cells to differentiate, or turn into normal white blood cells.

Phytates have been shown to inhibit the growth of human leukemia cells, colon cancer cells, both estrogen receptor - positive and negative breast cancer cells, voicebox cancer, cervical cancer, prostate cancer, liver tumors, pancreatic, melanoma, and muscle cancers.

Extensive scientific research has shown no relationship between feline leukemia and human leukemia.

FeLV (Feline Leukemia Virus) and FIV (Feline Immunodeficiency Virus) are both in the retrovirus category, the same type of virus responsible for HIV and some forms of human leukemia.

Not exact matches

Some of these risks include the presence of cytomegalovirus (CMV), hepatitis, human immunodeficiency virus (HIV), human T - cell leukemia virus type 1 (HTLV - 1) or other viruses on the pump parts that were exposed to the previous mother's breastmilk.

Some of the viruses that can be within breast milk are: HIV — Human Immunodeficiency Virus (AIDS) HTLV - 1 Human T - Cell Leukemia Virus Type I CMV — Cytomegalovirus When you are using a previously owned breast pump you create the risk of cross contamination.

Also, women with human T - cell leukemia virus type 1 (HTLV - 1) should not breastfeed because of the risk of transmission to the child.

For the infant, human milk reduces the rates of infection, allergies, obesity, diabetes, leukemia, lymphoma, SIDS, and infant mortality2.

According to U.S. Department of Health and Human Services (HHS), breast milk can lead to a lower risk of asthma, childhood leukemia, obesity, ear infections, sudden infant death syndrome (SIDS) and respiratory infections.

Few biological mechanisms may explain the inverse relationship between breastfeeding and leukemia including more favorable microbiome in an infant's gut and natural - killer and stem cells in human milk.

That's how Charles Sawyers, a 2009 Lasker Award winner and chair of human oncology and pathogenesis at Memorial Sloan - Kettering Cancer Center in New York City, made the connection with Bristol Myers Squibb (BMS) that led to second - generation treatments for chronic myeloid leukemia (CML).

Gene therapy procedures in humans have been linked to the onset of leukemia and various tumors, as well as sudden death.

«Formaldehyde has been shown in both humans and lab animals to cause structural and numerical changes in their chromosomes, which are associated with increased cancer risk, particularly with leukemia.

In another the therapy worked, but 4 of the 10 human subjects — young children — got leukemia.

The researchers have shown that it is possible to produce chromosome modifications in human cells that are genetically identical to those observed in leukemia and other types of human cancer.

By promoting DNA demethylation, high - dose vitamin C treatment induced stem cells to mature, and also suppressed the growth of leukemia cancer stem cells from human patients implanted in mice.

Then she applied her expertise to humans, studying chromosomal rearrangements in leukemia cells.

«Our partnership with families who have a child with Down syndrome and our investment in a comprehensive clinical data and biorepository will continue to provide resources to study not only heart defects, but also other Down - syndrome associated medical conditions such as cognitive function, leukemia, and dementia,» says co-author Stephanie Sherman, PhD, professor of human genetics at Emory University School of Medicine.

Coffin and his collaborator, Vinay Pathak, suggested that with each passage, the human cells acquired genetic portions of a murine leukemia virus, which then merged to form a new virus — a hybrid of the parent sequences.

No one had yet disproved that a murine leukemia virus was spreading through human population, she insisted — an observation greeted with skepticism and occasional derision by scientists who were following the controversy.

MLVs so dependably cause cancer in lab - bred mice — especially leukemia and lymphoma — that a small fraternity of scientists at the NCI and elsewhere has fruitfully studied these viruses since the 1960s in an effort to understand how human cancer begins.

In another the therapy worked, but 2 of the 10 human subjects — infants — got leukemia.

As a result of the finding, researchers can also use Mauritian cynomolgus macaques to improve stem cell transplant outcomes for human patients with other blood - related conditions such as leukemia and sickle - cell disease.

Scientists of the Senckenberg Center for Human Evolution and Paleoenvironment and the University of Tübingen have discovered what may well be the oldest known case of Leukemia.

Discuss how mouse models can be used to study human immune responses against leukemia (using primary or genetically modified leukemia cells) and melanoma

Rhesus monkey TRIM5α protects against HIV - 1, but the only modern virus that the human protein has any effect on is one that causes leukemia in mice — which happens to be closely related to PtERV1.

In an extensive sleuthing expedition that looked back nearly 20 years, two collaborating research teams contend that they have evidence that xenotropic murine leukemia virus — related virus (XMRV) resulted from the chance recombination of pieces of two mouse viruses in lab experiments and that the connections to human disease are spurious.

«We are now investigating chromosome fragile site formation in various human cell lines, including the chronic myeloid leukemia and Fragile X cells,» said Feng.

Research carried out at the Division of Genetics at Friedrich - Alexander - Universität Erlangen - Nürnberg (FAU) with support from the Institute for Human Genetics has now discovered another molecular cause for a particularly aggressive type of leukemia in infants.

A year later, Carlo Croce, now director of the Human Cancer Genetics Program at Ohio State University, reported that chronic lymphocytic leukemia (CLL), the most common form of the disease, was caused by deletion of two microRNA genes.

She ultimately chose to study leukemia patients» immune responses to bone marrow transplants, an area conducive to translational research in part because the work involves treating patients with human cells, which can be prepared at academic health centers.

One, the simian immunodeficiency virus, is the predecessor of HIV; the other is simian T - lymphotropic virus 1, whose descendant in humans, HTLV - 1, can cause leukemia.

To overcome this hurdle, researchers genetically engineered human T cells to produce a CAR protein that recognizes a glycopeptide found on various cancer cells but not normal cells, and then demonstrated its effectiveness in mice with leukemia and pancreatic cancer.

Their preliminary findings indicate that MUS81 - induced movement of DNA to the cytosol also occurs in human cancer cells, including prostate cancer, breast cancer, colorectal cancer, uterine cancer, leukemia, and melanoma cells.

The new study, led by Walter Mothes, a Yale microbial pathogens expert, involved creating one culture that mixed healthy rat cells with cells infected by the murine leukemia virus, a cancerous pathogen in rats and monkeys that is not known to affect humans.

The study, published June 9 in Cell Stem Cell, used human cells to define the RNA editing enzyme ADAR1's role in leukemia, and find a way to stop it.

This work is supported by the Leukemia & Lymphoma Society, the Human Frontiers Science Foundation, the NIH / National Institute of General Medical Sciences (GM088313), the American Cancer Society (121776), and the Human Frontiers Science Program.