Sentences with phrase «msc immunomodulatory»
Not exact matches
This new study suggests that iPSC - MSC - secreted factors modulate T cell responses by inhibiting the cleavage of caspases, in what represents a novel immunomodulatory mechanism [3].
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New research demonstrates how proinflammatory stimuli can promote the production of extracellular vesicles from MSCs with enhanced immunomodulatory capacity.
The new immunomodulatory mechanism uncovered employing an in vivo mouse model suggests that iPSC - MSCs secreted immunomodulatory factors inhibit the cleavage of caspases and suppress T cell responses to promote an anti-inflammatory environment.
The robust immunomodulatory capabilities of mesenchymal stem cells (MSCs) have propelled them into animal studies and preliminary clinical trials as a treatment for a series of immunological diseases.
Researchers studying the effects of iPSC - MSCs treatment in an in vivo mouse model discover a novel immunomodulatory mechanism involving caspase proteins
Bartholomew et al 53 first described the in vivo immunomodulatory properties of MSCs in a baboon model of skin transplantation.
In addition, the immunomodulatory effects of MSCs have been demonstrated in several conditions characterized by inflammation.
BM - MSCs demonstrate broad therapeutic potential, as seen by their angiogenesis - promoting capacities and their immunomodulatory properties.
Possible solutions can be provided by use of MSCs, which are known for their immunomodulatory properties, iPSCs, which are derived from the patient's own tissue, and of course autologous cell sources.