Sentences with phrase «many epithelial cancers»

Researchers at Oregon State University are pursuing a new concept in treatment of epithelial cancer, especially head and neck cancer, by using two promising «analogs» of an old compound that was once studied as a potent anti-tumor agent, but long ago abandoned because it was too toxic.

We use multiple mouse models combined with in vitro approaches to address the pleiotropic functions of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within tumors.

Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer.

«Many epithelial cancers — lung, liver, pancreatic — show high levels of Yap1.

Similar to primary keratinocytes, long - term — cultured squamous cell carcinoma (30) and many other epithelial cancer cells (30, 31) can also form different types of clones in culture.

The observations made herein are unlikely restricted to only PC3 cells as Du145 holoclones can also be serially passaged and sustain long - term propagation (31) and many other epithelial cancer cells form holoclones that also express CSC markers such as CD44 (30).

Interestingly, long - term — cultured human epithelial cancer cells in clonal cultures also form holoclones, meroclones, and paraclones, and tumor cell holoclones have been hypothesized to harbor stem - like cells or cancer stem cells.

Ginger extract has been shown to provide anti-cancer activity against both NSLC and cervical epithelial cancer.

However, in the 2014 denial letter, the agency admitted that talc «may elicit a foreign - body - type reaction and inflammatory response that, in some exposed women, may progress to epithelial cancers.»

Not exact matches

Vit A is required for normal vision, for maintaining the integrity and normal functioning of glandular and epithelial tissue, for skeletal growth, for maintenance of immunity, and for protection against certain cancers such as bronchial cancer.

Lactation and the risk of epithelial ovarian cancer.

The new study links UVB as protective to a total of 16 types of cancer, primarily epithelial (pertaining to the surface) cancers of the digestive and reproductive systems [Grant, submitted].

Background: Epidemiologic studies have yielded inconsistent findings between breastfeeding and epithelial ovarian cancer (EOC) risk.

Geoff Oxnard, an assistant professor of medicine at Dana - Farber Cancer Institute and Harvard Medical School in Boston and one of Paweletz's collaborators, remarks that «I had a hospitalized patient last week, she's sick with metastatic lung cancer, and she's exactly the kind of patient who might have an [epithelial growth factor receptor (EGFR)-RSB- mutation, but I simply didn't have enough tissue to ask those questions yet.&Cancer Institute and Harvard Medical School in Boston and one of Paweletz's collaborators, remarks that «I had a hospitalized patient last week, she's sick with metastatic lung cancer, and she's exactly the kind of patient who might have an [epithelial growth factor receptor (EGFR)-RSB- mutation, but I simply didn't have enough tissue to ask those questions yet.&cancer, and she's exactly the kind of patient who might have an [epithelial growth factor receptor (EGFR)-RSB- mutation, but I simply didn't have enough tissue to ask those questions yet.»

This discovery is a result of research on the effects of ONA on a preclinical model of epithelial ovarian cancer (EOC) both in vivo and in vitro.

The scientists identified several, including the investigational cancer drug BEZ235, which blocked a key metabolic pathway in flu - infected human lung epithelial cells.

Lead author Moustafa Abdalla writes: «Almost all genomic studies of breast cancer have focused on well - established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells.»

Dr. Done explains: «Most breast cancer starts in the epithelial cells lining the mammary ducts.

To capture uncommon genetic variants, the study used an exome genotyping array to genotype 7,060 epithelial ovarian cancer (EOC) cases and 6,712 cancer - free women from the Ovarian Cancer Association Consocancer (EOC) cases and 6,712 cancer - free women from the Ovarian Cancer Association Consocancer - free women from the Ovarian Cancer Association ConsoCancer Association Consortium.

They also found differences in the types of bacteria in the upper reproductive tracts of women with and without epithelial ovarian cancer.

In the new study, DrugPredict suggested non-steroidal anti-inflammatory drugs, also known as NSAIDs, could have applications for epithelial ovarian cancer.

Indomethacin killed both drug - resistant and drug - sensitive epithelial ovarian cancer cells.

Interestingly, cisplatin - resistant epithelial ovarian cancer cells were most sensitive to indomethacin.

In the Oncogene study, DrugPredict produced a prioritized list of 6,996 chemicals with potential to treat epithelial ovarian cancer.

Yang et al. report on one such strategy: Taking the knowledge that an increase in type I interferons (IFNs) correlates positively with clinical outcome in several cancers and that type I IFNs can enhance antitumor immunity in some models, the authors tethered IFN - β to a monoclonal antibody targeting the epithelial growth factor receptor (EGFR), which is approved for use in treating metastatic colorectal cancer and head and neck cancer.

In one experiment, the researchers created arrays of mammary epithelial cells and asked how adding one or more cells expressing low levels of the cancer gene RasG12V affected the cells around them.

Almost 80 percent of cancers have epithelial cell origin.

«We showed that PLK1 drives migration of normal prostate epithelial and prostate cancer cells through an entirely different process.»

Recently published in the journal eLife and featured in a poster session at this year's American Association for Cancer Research (AACR) annual meeting, preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition Cancer Research (AACR) annual meeting, preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition (EMT).

A total of 640 women in the MMS group had surgery for suspected cancer, of whom 133 women had invasive epithelial ovarian cancers (iEOC).

The new research finds that the stiffness of the extracellular matrix and the availability of certain ligands (molecules that bind to cell membranes) can together determine which genes are actually called on — and whether normal epithelial cells begin to exhibit the behaviors characteristic of highly malignant cancer cells.

By manipulating it in vitro, a team of researchers led by Prof. David Mooney at Harvard SEAS have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

But by hierarchical clustering of observed alterations in endocytosis, the researchers identified two distinct cancer phenotype clusters, one marked by mutations in the oncogene KRAS in mesenchymal cells and the other by changes in epithelial cells.

The images show how a growth factor caused cells to change forms and regroup from tight packs of epithelial cells to more mobile, loose arrays of mesenchymal cells — information useful for studying cancer and wound healing.

The cell changes, known as an epithelial to mesenchymal transition, or EMT, are normal and helpful during wound healing, but problematic when cancer cells spread from the primary tumor site to other sites in the body.

«It is striking that these changes, found in many human cancers, can be induced in normal mammary epithelial cells simply by varying the stiffness or composition of the matrix surrounding them.»

A potentially promising new treatment strategy involves targeting the epithelial growth factor receptor (EGFR), which is frequently overexpressed in cervical cancer.

Researchers from the University of Michigan and the Mayo Clinic studied rat IEC - 6 intestinal epithelial cells, chosen because they maintain a stable diploid genomic structure (two sets of chromosomes), lack the cellular characteristics of cancer cells, and replicate normally.

HER2 - positive breast cancer, which is associated with poor prognosis, has been traced to an excess of signaling through receptors, or docking ports, called HER2 found on the surface of certain mammary epithelial cells.

«We found that women who consume foods high in two sub-groups of powerful substances called flavonoids — flavonols and flavanones — had a significantly lower risk of developing epithelial ovarian cancer.

The research reveals that women who consume foods containing flavonols and flavanones (both subclasses of dietary flavonoids) significantly decrease their risk of developing epithelial ovarian cancer, the fifth - leading cause of cancer death among women.

She said: «This is the first large - scale study looking into whether habitual intake of different flavonoids can reduce the risk of epithelial ovarian cancer.

The researchers found that this loss of identity allows the relatively well - behaved epithelial cells to transition to bad - acting mesynchemal cells, which are more likely to move throughout the body — the hallmark of metastatic cancer, which is the primary cause of cancer recurrence and patient death.

The goal of the first experiment was to see whether lncRNAs are differentially expressed in prostate cancer by measuring total RNA from prostate cancer cell lines and normal epithelial prostatic cells using NCode human ncRNA array and SurePrint G3 human lncRNA microarrays.

Researchers have built a model to investigate the metastasis of cancer by examining the metabolism of breast epithelial cells and look at the role of signaling.

In addition, the combination of defective epithelial barrier and abnormal epithelial cell extrusion observed in this mouse model may be further exploited to study the role of Alix in cancer.

In search of early markers of lung cancer, pulmonary and critical care physicians Avrum Spira and Jerome Brody of the Boston Medical Center sampled bronchial tube epithelial cells from 85 people.

In a study of 51 patients, researchers used a state - of - the art microfluidic device to capture circulating pancreas epithelial cells in 33 percent of patients with early pancreatic lesions and no clinical diagnosis of cancer.

Additionally, overexpression of POSTN in human mammary epithelial and breast cancer cells resulted in enhanced tumor growth and metastasis (Wang et al., 2013), which is similar to a colon cancer cell model where overexpression of POSTN resulted in an increase in the number and size of liver metastases (Bao et al., 2004).

Researchers captured circulating epithelial cells in 73 percent of patients with cancer.