Sentences with phrase «many human cancer»

'' «At PMV Pharmaceuticals, we are targeting the most frequently mutated gene in human cancer (p53) to make an unprecedented impact on cancer patients» lives.

Islam is a human cancer.

Those who feel there is something «unnatural» about introducing human genes into animals or plants forget that we share a high proportion of our genes with these species already: it is precisely this collective heritage that allows experiments on frogs to spawn treatments for human cancer.

The field of cancer epigenetics was recently transformed by the finding that genes encoding for epigenetic regulators are among the most commonly mutated genes in human cancers.

Chronic cigarette smoke exposure, as noted in many human cancers, tends to block these cell maturation genes from properly turning on, says Baylin.

Following that, I joined Celera's proteomics initiative, which was trying to unravel the complex proteomic signatures in human cancers.

By studying human cancer cells and animal models of cancer in the lab, our researchers have shown that loss of PTEN leads to high levels of PI (3,4) P2, which could result in hyperactivation of AKT.

Tumor virology has survived its failure to find abundant viral agents of human cancer.

At the same time, the study results provide further argument for notion that m6A methylation, partly controlled by ZFP217 signaling, is relevant in human cancers.

For example, RNA - binding proteins are overexpressed in many human cancers, and mutations in some of these proteins have been linked to neurological and neurodegenerative disorders such as amyotrophic lateral sclerosis.

The process of integrating naturally occurring cancers in dogs into the general studies of human cancer biology and therapy is known as comparative oncology.

Studies have shown that more than 50 % of all human cancers carry defects in the p53 gene, and almost all other cancers with a normal p53 function carry other defects which indirectly impair the cancer - fighting function of p53.

In addition, they injected mice with human cancer cells and found that the tumors grown in mice could be inhibited with PD173074.

In their latest study, they tested compounds against cells from nine different types of human cancer, including common types affecting blood, colon, breast, prostate, ovaries, kidneys, and lungs.

«Now, in this report, we show that this mechanism is at work in many human cancers.

Moreno also found a homologue of a human cancer gene involved in cell competition.

By studying this phenomenon in horses you can learn about human cancer and vice versa.»

The researchers have shown that it is possible to produce chromosome modifications in human cells that are genetically identical to those observed in leukemia and other types of human cancer.

Genetically reprogramming late - stage human cancer cells to a stem - cell state enabled them to force the reprogrammed cells to progress to an early cancerous state, revealing secreted blood biomarkers of early - stage disease along the way.

The tissue barrier, about four cells deep, was made from «BeWo» human cancer cells.

Avivi's team has found out that fibroblast skin cells from the armpits of the rats can kill human cancer cells in a dish.

The antigen comes from a virus, SV40, linked to human cancers such as brain and bone cancers, mesothelioma and lymphoma.

«Dirty bombs» strapped to listeria bacteria cleared tumours in mice with the most lethal human cancer

The new study doesn't provide direct evidence of this group migration in human cancer.

But she notes that even if the rodent finding is mirrored in people, only a subset of human cancers would be influenced by the drugs — those not already abundant in NRF2.

«This work sheds new light on how blood cancer develops and also provides a new approach that can be used to study chromosomal deletions associated with a variety of human cancers, neurological and developmental diseases.»

He says it's also important to understand the protein's biological role in cellular signaling and normal animal development as well as to consolidate its role in human cancer development, progression and drug - resistance.

PE: If I were going to put my money on it, I would bet that by 2050 — hopefully earlier — we'll have found that more than 80 percent of all human cancer is caused by infection.

«We knew ZMYND11 was a candidate tumor - suppressor because it's down - regulated in a number of human cancers, including breast cancer,» Shi said.

«We found that AIM2 inhibits tumorigenesis in multiple animal models of colorectal cancer by restricting the pro-survival signaling molecule, Akt, which is commonly hyperactive in many human cancers.»

Two other big initiatives fared better: a proteomics effort to identify proteins in blood and other biomarkers that might work as early warning signs of cancer, and the most recent: a human Cancer Genome Atlas.

Researchers have decoded the chemistry of the first of a wealth of unique compounds produced by a new genus of bacteria that dwells in deep - ocean sediments, and they have found it to be a potent inhibitor of human cancers in lab experiments.

I would bet that by 2050 we'll have found that more than 80 percent of all human cancer is caused by infection.

He had been experimenting with human cancer cells, microbes, and mothers» milk.

The study not only shows that NPTX2 is active in kidney cancer, but is the first to reveal that the gene is over-expressed in any human cancer.

A small dose of 1.56 µM, which is approximately equivalent to a daily dose of the drug in a human cancer patients, increased the fruit flies» average life expectancy by 8 %.

MLVs so dependably cause cancer in lab - bred mice — especially leukemia and lymphoma — that a small fraternity of scientists at the NCI and elsewhere has fruitfully studied these viruses since the 1960s in an effort to understand how human cancer begins.

«Given that approximately 12 percent of human cancers worldwide may be attributed to viruses, and there are no vaccines currently available for these five viruses, prevention strategies to reduce the infections that can lead to cancer are even more critical,» said Linda Birnbaum, Ph.D., director of the National Institute of Environmental Health Sciences (NIEHS) and National Toxicology Program (NTP).

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

In studies of mice injected with human cancer cells, the drug appeared to work according to plan.

He has chaired numerous NIH committees and served on the National Advisory Council for Human Genome Research and the NCI Mouce Models for Human Cancer Consortium.

However, in tests on tissues removed from 253 human cancer patients, the MasSpec Pen took about 10 seconds to provide a diagnosis and was more than 96 percent accurate.

And among lab animals, rats are considered particularly relevant to human cancer studies because they need the same nutrients and proportion of protein for maximal growth as humans.

The researchers further found that miR - 486 is itself regulated by the tumor - suppressor gene p53, the most frequently altered gene in human cancers, and that activity of miR - 486 is partially dependent upon functional p53.

They tested these drugs one at a time for lethal interaction with 112 different tumor - suppressor gene mutations in human cancer cells growing in the lab.

Using in vitro, or test tube, experiments, the researchers applied these chemicals to human cancer cells to measure changes of estrogen receptor - and androgen receptor - target genes and transcriptional activity.

The size difference between tumor and healthy circulating DNA was initially discovered in animal tumor models created by inducing tumors with human cancer cells.

Biological data also suggest, but do not prove, that the virus can sometimes cause human cancer.

Cucinotta said the findings show a tremendous need for additional studies focused on cosmic ray exposures to tissues that dominate human cancer risks, and that these should begin prior to long - term space missions outside the Earth's geomagnetic sphere.

Someday, targeted inhibition of Hh signaling may be effective in the treatment and prevention of many types of human cancers.