Sentences with phrase «many mechanisms of resistance»
The mechanism of resistance in this variety was found to be antibiosis, and the level of resistance was found to be equal to that of the most resistant sources known to sorghum breeders in the world.
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«Indeed, we believe AR - V7 and other, related variants are a mechanism of resistance in this disease and patients who have them may have a poorer prognosis.»
«This fact reinforces just how complex the mechanisms of resistance to chemotherapy can be,» says Luke Whitesell, a senior author of the PNAS paper and senior scientist at Whitehead Institute
The major mechanism of resistance involves the introduction of mutations in genes encoding penicillin - binding proteins.
«The surprising part was that the mechanisms of resistance all funneled through one signaling pathway, ultimately, but the way that they start is frequently different,» said Dr. Aplin.
«Here, we show that the BRAF inhibitors induce autophagy as a way to escape cell death, which gives us clues on how to interfere with this mechanism of resistance and improve outcomes for these patients.»
Using tumor biopsies from BRAF melanoma patients treated with either BRAF inhibitors or with combined BRAF and MEK inhibitors, a recently FDA - approved drug combination to fight the other mechanisms of resistance, the researchers found that tumors resistant to the BRAF inhibitors had increased levels of autophagy compared with baseline tumors.
Wilson, M. Z.; Wang, R.; Gitai, Z.; Seyedsayamdost, M. R. «Tropodithietic Acid: Mode of Action and Mechanism of Resistance.»
Dr. Douillard, lead author of the study, says his next steps are to «look for resistance mutations, like T790M, during treatment to better understand mechanisms of resistance and anticipate later line treatment at progression.»
Adds Tsvetkov: «We know a mechanism of resistance now.
What's interesting is the mechanism of resistance to PPOs.
Although the general mechanism of resistance has been known for some time, exactly how M2 functions was less clear.
The lab of Elisa Oricchio at EPFL has now carried out a study to identify mechanisms of resistance to ibrutinib.
«Professor Mobashery has been working on the mechanisms of resistance in MRSA for a very long time,» Chang said.
«This may be compensatory and a mechanism of resistance to anti-psoriasis therapy, and it suggests that the solenopsin compounds could be used in combination with existing approaches,» Arbiser says.
But we need to be prepared for the mechanism of resistance and for the likelihood of making the cancer more aggressive,» Crawford says.
However, sooner or later, insect species may be able to develop a mechanism of resistance against any pesticides.
«Many mechanisms of resistance to Bt proteins have been proposed and studied in the lab, but this is the first analysis of the molecular genetic basis of severe pest resistance to a Bt crop in the field,» said Bruce Tabashnik, one of the paper's authors and the head of the Department of Entomology in the UA College of Agriculture and Life Sciences.
The researchers, including scientists from pharmaceutical company AstraZeneca, report in an advanced online publication in Nature Medicine on May 4, that their findings indicate «an underappreciated genomic heterogeneity» in mechanisms of resistance to tyrosine kinase inhibitor (TKI) drugs that target the Epidermal Growth Factor Receptor (EGFR) mutation that drive some cases of non-small cell lung cancer (NSCLC).
The researchers learned that the astonishing diversity of cadherin in pink bollworm from India is caused by alternative splicing, a novel mechanism of resistance that allows a single DNA sequence to code for many variants of a protein.
Additional studies in which we more precisely define the mechanisms of resistance and growth in an individual's tumor with genomic sequencing, and other means, will be important to maximize the ability to target all the critical pathways to achieve greater success.»
The researchers also suggest further research on the mechanisms of resistance and cross-resistance within the flea vector, to gain a fuller understanding of how insecticide develops and spreads across populations.
New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.
Previosly in a preclinical study BRAF inhibitor - resistant mutated BRAF melanoma cells were developed as an experimental model system to mimic BRAF inhibitor - resistant melanoma patients and to study the mechanisms of resistance.
Similar approaches could be used to study the molecular basis of response to a given therapy, as well as mechanisms of resistance to treatment.
In the longer - term, the findings provide an important resource for exploring the underlying mechanisms of resistance.
This target identification platform is used to identify novel targets and rational combinations and mechanisms of resistance to our current programs.
As a result, we are finding similar mechanisms of resistance.
Multiple mechanisms of resistance to PARPi have been proposed (reviewed in ref.
However, the mechanism of resistance in prostate cancer, and to PARPi other than olaparib, is unknown.
Therefore, strategies for understanding mechanisms of resistance and determining how to therapeutically target specific gene fusion partners are also being explored.
His research aims to understand mechanisms of resistance to targeted therapies in cancer and identify potential therapies to overcome that resistance.
Genotype - driven early phase trials, including exceptional responders and mechanisms of resistance and immune mechanisms in cancer and cellular therapy.
An area of focus is the determinants of response and mechanisms of resistance to BRAF inhibitors and his findings on next generation BRAF inhibitors are translating to an industry - sponsored clinical trial in mutant BRAF - harboring solid tumors (e.g. lung, thyroid, skin (NCT02428712)-RRB-.
«Many mechanisms of resistance seem to be in play in these various populations simultaneously,» said study co-author Kenneth Haynes, an entomologist at the University of Kentucky.
(The mechanisms of resistance in most afflicted patients remain unknown.)
Not exact matches
Identifying resistance mechanisms and creating non-invasive tests to aid in the selection and monitoring of patients during clinical trials.
The Weider bench features the Ultimate Body Works, a unique resistance mechanism that uses your own body weight coupled with resistance bands to provide an extra 50 lbs of resistance.
There are a variety of mechanisms of immune resistance that operate in the tumor.
For half of these patients (49 %), resistance mechanisms varied between biopsies, including both «gain» and «loss» of the T790M mutation (20 % and 11 % of two - biopsy patients, respectively).
Three of the 17 patients who «lost» T790M demonstrated a new resistance mechanism on the second biopsy.
If only we had done this experiment 15 years ago, when vancomycin came into widespread use, we might have understood exactly what kind of resistance mechanisms would follow the drug into our clinics and hospitals.»
«Naturally occurring mechanism of cancer drug - resistance may itself be a treatment target.»
This could be key given that the underlying mechanisms of metastasis and resistance to cancer drugs are nothing if not complex interactions in a biological system.
«However, recently, we discovered a counterintuitive mechanism by which cells can acquire resistance to proteasome inhibitors in vitro,» explains Peter Tsvetkov, lead author of the PNAS article and a post-doctoral researcher at Whitehead Institute.
A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.
Researchers at Roswell Park Cancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast cancer.
Although proteasome inhibitors are very efficient in selective killing of cancer tumor cells grown in a dish (in - vitro), their success in the clinic has largely been undermined by the development of resistance — mechanisms of which are poorly understood.
(Hons) program, I moved to the Bose Research Institute in Calcutta for an apprenticeship in Anadi Chatterjee's laboratory to work on the mechanism of penicillin action and methicillin resistance in Staphylococcus aureus.
Adult drug resistant cancer cells may contribute to this problem, and the authors discuss these and other cancer drug resistance mechanisms in their recent publication in the September issue of the journal Cancers.