Sentences with phrase «many of the gene variants»

Of these, 43 people carried at least one copy of the gene variant.

If the new combination of gene variants make the offspring better suited for growth in its current environment, that bacterium will rapidly divide asexually, outcompete its parental (or sibling) strains and become established as an emerging strain or species in its own right.

We screened a total of 394 Amish research subjects for the KCNH7 mutation; 84 of these individuals carried at least one copy of the gene variant, and the lifetime incidence of bipolar spectrum disorders among them was 49 percent (41 people were affected with the disease).

The increased risk closely correlates with the frequency of a gene variant previously associated with that adverse reaction, supporting recommendations to screen for that variant in patients from those populations.

Scientists also know dozens of gene variants that increase people's risk of lupus.

«We don't know if studying the fish will directly help us,» said Rohner, «but evolution has tried a lot of gene variants over millions of years and I think that's smarter than anything we can come up with, even with machine learning.

The new study focused on 40 cognitively healthy older adults between the ages of 65 and 75 who are carriers of a gene variant (APOE e4) that is known to contribute to the risk of developing late - onset Alzheimer's disease.

«How a drug is going to work on a carrier of the gene variant could be worse or it could be better, but it's likely going to be different,» Connor said.

This is the prospect raised by the discovery of gene variants that seem to predict whether an individual will produce enough antibodies in response to a vaccine to protect them against disease.

There are a number of gene variants that may hold the key to a healthy old age life.

Researchers have identified a new host of gene variants that could make people vulnerable to sporadic motor neuron disease, according to a report published in the journal, Scientific Reports.

Seven of these gene variants, as expected, appeared to increase risk for both diseases.

«Many of the gene variants that cause light skin in Europe have origins in Africa,» Tishkoff says.

The researchers found that people who have more copies of the gene variants (by inheriting a copy of each advantageous variant from both parents), had the least amount of oxygen in their blood and used it more efficiently than people without either variant, or only one copy from one parent.

The team demonstrated that some of these gene variants are capable of stimulating cancer growth.

By sequencing a remarkably complete genome from a 50,000 - year - old bone fragment of a female Neandertal found in Vindija Cave in Croatia, researchers report a new trove of gene variants that living people outside of Africa obtained from Neandertals.

The identification of gene variants that delay fracture healing could lead to screening tests for patients with broken bones.

«It might be difficult to imagine why the large number of gene variants that together give rise to traits like [autism spectrum disorder] are retained in human populations,» co-author and genetics and neuroscience professor Joel Gelernter said in a statement from Yale University.

Closer examination of this gene variant suggested it may regulate the expression of a neighboring gene, SLC39A8, which is known to help protect the airways and lungs from inflammation and cellular damage.

Tests may be ordered specifically looking for carrier status, identifying people who carry one copy of a gene variant that can be passed on to a child.

In the most extreme cases, about a quarter of the genomes of Przewalski's horses consisted of gene variants inherited from domesticated horses.

«We found that while hybridisation has not compromised the genetic distinctiveness of wolf populations, a large number of wild wolves in Eurasia carry a small proportion of gene variants derived from dogs, leading to the ambiguity of how we define genetically «pure wolves».

The trial was designed to examine the effect of various doses of DG031 on certain biomarkers linked to arterial inflammation and risk of heart attack in patients with a history of heart attack and one or more of the gene variants deCODE has linked to increased risk of the disease.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

the evolution of domesticated animals has been underway for so long that we can now see the evolution of gene variants, that is, genes in which several successive mutations gradually changed the function of the gene.

November 10, 2005 Major discovery with rapid applicability to the development of new medicine Reykjavik, ICELAND, November 10, 2005 — A paper by a deCODE - led team of scientists published today presents the discovery of a gene variant conferring increased risk of...

Initiated in February 1998, and covering up to 12 common diseases, the five - year collaboration is focusing on the discovery of gene variants that predispose and / or contribute to the development of these diseases, with a major emphasis on six of them.

A deeper meta - analysis looking at a longer list of gene variants is currently underway, and individual groups within the consortium are using the pooled dataset to answer additional questions.

About 35 % of Americans have one or two copies of this gene variant, inherited from one or both parents.

They compared a genetic marker in a population in India (most of which ate meat) to a U.S. population and found higher rates of a gene variant that facilitates the elongation of omega 6 fatty acids.

If you have two copies of this gene variant, you metabolize caffeine much slower than «fast» caffeine metabolizers.

The widely used strategy of allele association investigates correlations of gene variants with phenotypes, i.e., it probes if individuals with a trait of interest carry a specific gene variant more frequently than individuals in a control group (case - control studies).

Not exact matches

The company will now be able to sell health risk reports on three variants found on the BRCA1 and BRCA2 genes, which are linked with a higher risk of breast, ovarian, and prostate cancer.

To illustrate how it works in practice, Koenig offers the example of a professional hockey player whose profile shows that he has gene variants found in people who respond rapidly to lactic - acid threshold training.

Athletigen's process involves taking a sample of an athlete's saliva and subjecting it to genotyping analysis to search for 850,000 different gene variants that may play a role in the formation of athletic traits.

Collaboration based on new findings from the Regeneron Genetics Center ® showing variant in HSD17B13 gene is associated with reduced risk of chronic liver diseases

These genes are implicated in highly penetrant genetic disorders for which surgical or other interventions aimed at preventing or significantly reducing morbidity and mortality are available to pathogenic variant carriers.5 Identification of a pathogenic variant in one of these genes could be diagnostic of a medical condition with potential implications for an individual's medical management.

This team also discovered 3,200 genes that had fewer loss - of - function or missense mutations than would be expected suggesting that these are likely disease - causing variants that are rare or absent in the population because of their detrimental effect on human health.

Mostly they are optimists, excited by the latest findings: the newly isolated gene variant that may help explain schizophrenia, the new telescopic images that reveal the violent births of distant....

Some genes have a variety of different forms, which are located at the same position on a chromosome; an allele is such a variant form of a gene.

Some researchers have looked into what role genes might have in our tendency to cheat, like last year's study on a certain variant of the dopamine gene DRD4 — and dopamine is the force behind our sexual drives, survival needs and pair - bonding behaviors.

For those who have MTHFR gene variants, supplemental folic acid has not been found to reduce the risk of miscarriage.

Since all people have two copies of every gene, combinations of the TAS2R8 gene variants determine whether someone tastes bitter foods intensely.

Genetic Variants of the FADS1 FADS2 Gene Cluster Are Associated with Altered (n - 6) and (n - 3) Essential Fatty Acids in Plasma and Erythrocyte Phospholipids in Women during Pregnancy and in Breast Milk during Lactation

I've heard that half of East Asians have at least one variant gene.

For their experiments, the researchers created hybrids of two genetically distinct mouse strains with a fully sequenced genome, allowing gene variants to be clearly assigned to the maternal or paternal allele.

Three of the darker - skin gene variants appear to have evolved from variants linked with less pigment.

No particular genetic variant was shared across all synesthetes in all three families, suggesting there is no single «synesthesia gene» or set of genes.

Every gene in (almost) every cell of the body is present in two variants — so called alleles: one is deriving from the mother, the other one from the father.

But a faulty variant of this gene arose six generations ago in an Amish group, causing the people who carry one copy of the variant to produce half as much of the age - promoting protein.