Sentences with phrase «marburg filoviruses»

The study, published by EcoHealth Alliance's Dr. Kevin Olival and Dr. David Hayman from Massey University, reviewed all of the current literature on filoviruses — the class of viruses that include both Ebola and Marburg virus — and took a critical look at the ecological and virological methods needed to understand these viruses to protect human health.

The largest outbreak on record for the filovirus family was caused by Ebola virus in West Africa between 2013 and 2016, resulting in more than 28,000 infections and more than 11,000 deaths.

One of these chemical structures, benzoquinoline, showed antiviral activity against Ebola virus and was also active against another deadly filovirus, Marburg virus.

Comprehensive panel of real - time TaqMan polymerase chain reaction assays for detection and absolute quantification of filoviruses, arenaviruses, and New World hantaviruses

Diagnostic reverse - transcription polymerase chain reaction kit for filoviruses based on the strain collections of all European biosafety level 4 laboratories

«A nice thing about the filovirus field is that it was populated by very straightforward, salt - of - the - earth people,» she says.

The viruses in question belong to two families: Filoviruses, which include Ebola and Marburg, and Bornaviruses, which causes neurological diseases in certain animals, such as horses.

That said, it's still too early to know whether Bornaviruses and Filoviruses are really overrepresented, says Derek Taylor, an evolutionary biologist at the University at Buffalo in New York.

But equally intriguing was how few different families of RNA viruses turned up: just Bornaviruses and Filoviruses.

Of these, only half have ever been tested for filovirus, says Peterson.

The researchers engineered a DNAzyme with two loops: one to detect to detect the Marburg sequence, and another to detect a sequence common to all filoviruses, which includes Marburg and all strains of Ebola.

Adding the filovirus sequence without the Marburg sequence would generate a pink «E» in the wells.

«These data provide the basis for understanding the immune response to filovirus infections in humans,» said Bukreyev.

However, in the 40 years since the first Ebola outbreak, fruit bats have been found to be probable reservoirs for filoviruses — the type that causes Ebola — and the Ebola genome and antibodies have been found in bat and rodent species in East and West Africa.

«The work on antibodies isolated from survivors of filovirus infections, including Marburg and Ebola, was started by James Crowe's laboratory at Vanderbilt University together with our laboratory about 3 years ago,» said virologist Alex Bukreyev, professor at UTMB and co-corresponding author.

«Our results provide a roadmap to developing a single antibody - based treatment effective against not only infections caused by Ebola Zaire virus, but also caused by related filoviruses.»

The question is, can these antibodies protect against a future infection with the virus and related filoviruses?

Fedson says that many scientists who study filoviruses like Ebola have yet to catch on to the idea of treating the immune response.

The WHO filovirus clinical working group, convened in response to the current outbreak, discussed the evidence on convalescents» serum at a meeting in Geneva, Switzerland, at the end of July, says Bausch, who is part of the group.

Because three kinds of bats from the region are believed to harbor the deadly filovirus.

Feldmann and his colleagues are reporting their results at the 7th International Symposium of Filoviruses in Washington, D.C., this week.

Had the then -67-year-old Hoffman — who brought mainstream culture face to face with autism in Rain Man and went mano a mano with an Ebola - like filovirus in Outbreak — never quite broken character from his 1982 film Tootsie?

Under new WHO guidance, it would now get a name like «filovirus - associated haemorrhagic fever 2.»

In a study reported online this week in BMC Evolutionary Biology, the researchers conclude that filoviruses have existed for tens of millions of years.

Filoviruses are RNA viruses that don't carry the gene for reverse transcriptase, yet that hasn't stopped them from somehow leaving their mark.

Although outbreaks are rare, Ebola virus, Marburg virus, and other so - called filoviruses periodically cause massive hemorrhaging in humans, chimpanzees, gorillas, and other primates.

They arrived at that estimate by showing that the Norway rat and the house mouse, which diverged from each other somewhere between 12 million and 24 million years ago, have the same filovirus gene pieces integrated at the same places on the same chromosomes.

Some reports based on the estimated mutation rate of this virus family have suggested that filoviruses are a mere 10,000 years old, but Derek Taylor, an evolutionary biologist at the State University of New York (SUNY), Buffalo, has found a new way to gauge their age.

Presentation: «Nucleotide Prodrug GS - 5734 Is a Broad - Spectrum Filovirus Inhibitor that Provides Complete Therapeutic Protection Against Ebola Virus Disease in Infected Non-human Primates.»

For the published broad agency announcement, see the April 29, 2016 solicitation, Advanced Development of Multivalent Vaccine Candidates for Filovirus and Lassa Fever.

Finding comparable safety and immunogenicity in U.S. and Ugandan populations provided proof of principle that a protective, multivalent filovirus vaccine is attainable.

Her work included the genome sequencing of the Ebola and Marburg filoviruses and Lassa Fever, as well as joint work to develop possible therapies.

The team is also working on prevention of related Ebolavirus members Sudan virus (SUDV) and Bundibugyo virus (BDBV), and the related filovirus Marburg virus.

Developed and optimized protocols for detection of hemorrhagic fever viruses including Filoviruses, Arenaviruses and Bunyaviruses (Ebola, Marburg, Lassa, Machupo, CCHF, Rift Valley Fever and others).