Sentences with phrase «matrix microenvironment»
Dr Normand Pouliot is Head of the Matrix Microenvironment and Metastasis Laboratory.
http://www.onjcancercentre.org/ Not exact matches
«Ionizing radiation found to soften tumor cell microenvironment: When irradiated, less stiff extracellular matrices reduced cancer growth and migration, bolstering the case to further understand fractionated radiation therapy.»
The problem with only tuning the stiffness of a cell's microenvironment, also known as the extracellular matrix, is that it assumes the environment behaves like an elastic material, like rubber.
One reason that fast - relaxing microenvironments promote more osteogenesis and form bone is that cells inside these matrices can mechanically remodel the matrix and more easily change shape, said Ovijit Chaudhuri, former postdoctoral fellow in the Mooney lab and co-first author.
Tightly anchored tissue - mimetic matrices as instructive stem cell microenvironments.
Matrix engineering: Decellularized or reconstituted biopolymer matrices and modular, biofunctional hydrogels are designed to create cell - instructive microenvironments and morphogenetic matrices for regenerative therapies.
Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment.
Prewitz MC, Seib FP, von BM, Friedrichs J, Stissel A, Niehage C, Muller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C Tightly anchored tissue - mimetic matrices as instructive stem cell microenvironments.
Marina Prewitz (Werner, LG)-- «Decellularised extracellular matrices as instructive microenvironments for bone marrow derived stem cells» (2011)
Tissue engineered human primary osteoblast matrices and scaffold / hOsteoblast constructs applied to tumour / bone microenvironment research.
The cell microenvironment contains chemical and physical cues that arise from a complex, albeit defined, architecture of extracellular matrix networks.
Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion.
The Herlyn lab is differentiating multi-potent stem cells from the human dermis and reprogrammed stem cells into melanocytes to test the hypothesis that melanocyte stem cells are more prone to transformation than fully differentiated cells, and that neighboring cells and matrix in the microenvironment play critical roles in differentiation and transformation.
When breast cancer cells invade the bone microenvironment, they produce molecules that activate osteoclastic bone resorption, leading to the release of growth factors stored in the bone matrix to promote tumor growth.
His studies revealed that the blood and lymphatic vasculature, fibroblasts, immune cells and the extracellular matrix associated with tumors are abnormal, collectively creating a hostile tumor microenvironment characterized by hypoxia, low pH and high interstitial fluid pressure.