Sentences with phrase «mechanisms of disease at»

Tuncay Baubec, professor at the Department of Molecular Mechanisms of Disease at the University of Zurich, and his team have shown that one particular protein plays an important part in this process: The DNA methyltransferase 3A (DNMT3A) enzyme is responsible for positioning the methylation to the right place on the DNA.

Not exact matches

He also noted that many drugs aimed at lessening the effects of Alzheimer's disease work by attempting to improve this attention mechanism.

Interested in the fundamental biology of real - world problems, he accumulated a wide range of research skills to better investigate the molecular mechanisms at play in neurodegenerative diseases like Parkinson's and Alzheimer's.

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

Understanding this new mechanism of cardiovascular disease could lead to the development of new therapies to treat individuals who suffer from heart and blood vessel ailments due to these mutations,» explained corresponding author Kenneth Walsh, PhD, professor of medicine at BUSM.

Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.

Scientist at the University of Copenhagen and Skejby Hospital will continue their work on how bacteria might affect the balance between the immune defence mechanism and the disease.

«Our study reveals a new mechanism that could be harnessed for biological therapies for lupus and other autoimmune diseases, where the immune system mistakenly targets the body's own cells,» says senior study author Boris Reizis, PhD, professor of Pathology and Medicine at NYU Langone.

As someone who's been at the forefront of unraveling emerging infectious diseases and the mechanisms of pandemics, what keeps you up at night?

«We were very surprised to find alterations in proteins that are responsible for RNA splicing in Alzheimer's, which could have major implications for the disease mechanism,» says Allan Levey, MD, PhD, chair of neurology at Emory University School of Medicine and director of the Emory ADRC.

«We have identified some 40 rare diseases where this mechanism can be produced at the level of similar trios of genes,» says Dr. Gueant.

This mechanism may be involved in many more diseases,» explains study's co-author, Dr. David Rosenblatt, a scientist in the Child Health and Human Development Program at the RI - MUHC and holder of the Dodd Q. Chu and Family Chair in Medical Genetics in the Department of Human Genetics at McGill University.

New research, led by scientists at the University of Southampton, has found that neurogenesis, the self - repairing mechanism of the adult brain, can help to preserve brain function in neurodegenerative diseases such as Alzheimer's, Prion or Parkinson's.

«Further work in our lab will be aimed at understanding the detailed mechanism of how these proteins regulate editing, in turn providing an inroad to developing therapeutics that modulate editing for the treatment of human diseases.»

But translation is not one - way; the insights gained at the bedside, and from clinical and population - based studies, will spawn hypotheses, enabling scientists to probe the mechanisms of disease in new ways and ultimately enriching basic biology.

Dr. Alan S. Cross, Professor of Medicine at University of Maryland School of Medicine, who was not involved in the research, shared his input: «This is a major conceptual breakthrough in our understanding of infection and immune disease mechanisms and may have implications for novel approaches to the treatment of other diseases characterized by cytokine storm.

«The burning question posed by this work is whether similar mechanisms operate in more common neurodegenerative diseases characterised by pathological protein deposits, including Alzheimer's, Parkinson's and Huntington's disease,» says Andy Randall at the University of Bristol, UK.

«Results also identified mechanisms regulating the numbers and phenotype of macrophages in the tiny air sacs of the lungs (called alveoli) in health and disease,» said Takuji Suzuki, MD, PhD, the study's first author and a scientist in the Division of Neonatology and Pulmonary Biology at Cincinnati Children's.

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

The investigators suggest that the premature loss of estrogen caused by the oophorectomy may affect a series of aging mechanisms at the cellular and tissue level across the whole body leading to diseases in multiple systems and organs.

Not long after the IOM report was published, NIH issued its own written assessment, concluding that research has neglected many of the biological factors behind ME / CFS and urging more basic science aimed at teasing out the mechanisms of the disease.

Understanding the underlying protective mechanisms in the lower risk individuals could help design novel therapeutic strategies targeting those at higher risk of disease.

Researchers at Duke University School of Medicine and Brigham and Women's Hospital, Harvard Medical School have identified a mechanism that explains why some mutations can be disease - causing in one genome but benign in another.

«Our study highlights the sensory aspects of basal ganglia function and presents a new approach to the mechanisms behind the sensory impairments seen in Parkinson's disease,» says Gilad Silberberg, associate professor at Karolinska Institutet's Department of Neuroscience.

«We tried to untangle the large role aging appears to play in some of the most devastating neurological disorders,» said Edward Giniger, Ph.D., senior investigator at the NIH's National Institute of Neurological Disorders and Stroke and the senior author of the study published in Disease Models & Mechanisms.

The discovery of hormones that apparently control life span, or some aspect of agerelated diseases in worms and mice, hints at a general biological mechanism for health and longevity that extends beyond any single organism.

Now, in an article published in Disease Models & Mechanisms, a team from the University of Alabama at Birmingham and Stanford University School of Medicine describe the use of a BDNF loop domain mimetic to improve motor function and object location memory in a mouse model of Rett syndrome.

Kathleen Kelly, a cancer biologist at NCI, is optimistic that the work will enhance understanding of the basic mechanism of the disease.

Splicing is a critical biological mechanism — at least 15 percent of all human diseases are due to splicing errors, for example.

«We're trying to get at the heart of the mechanism behind neurodegenerative diseases and with this research believe we've found one that seems to be commonly disrupted in many of them, suggesting that similar drugs may work for some or all of these disorders,» says Jeffrey Rothstein, M.D., Ph.D., a professor of neurology and neuroscience, and director of the Brain Science Institute and the Robert Packard Center for ALS Research at the Johns Hopkins University School of Medicine.

«The field has been driven by amyloid for the past 15, 20 years and we have to look at other things because we still do not understand the mechanism of disease or how to develop effective therapeutics.»

A $ 1.6 million effort to study the complex mechanisms of the disease and identify existing drugs that might be able to be used for Alzheimer's treatment or prevention, led by Eric Schadt of Icahn School of Medicine at Mount Sinai in New York City.

Researchers from the Institute of Neuroscience at the Universitat Autònoma de Barcelona have discovered the cellular mechanism involved in memory consolidation and were able to develop a gene therapy which reverses the loss of memory in mice models with initial stages of Alzheimer's disease.

«Knowing this mechanism that underlies IL - 37's effect on the immune system now allows us to study IL - 37 function and perhaps dysfunction in a wide range of diseases,» says Mayumi Fujita, MD, PhD, investigator at the University of Colorado Cancer Center, associate professor in the CU School of Medicine Department of Dermatology, and the paper's senior author.

«Our data support a paradox, wherein mechanisms that are thought to clear the bacteria at these sites actually may be promoting increased survival of bacteria and contributing to disease severity,» says Dr. Mason, who also is an assistant professor of pediatrics at The Ohio State University College of Medicine.

At Merck Frosst Canada, I have been an integral part of the discovery of a new molecule, the testing of its mechanism of action, the validation of its safety and efficacy in Phase IIb and III clinical trials, the market approval of the resulting product, and the subsequent management of patients and their disease.

If we want to treat the disease, we must first understand the underlying mechanism,» says Dr Jenny Björkqvist at the Department of Molecular Medicine and Surgery, Karolinska Institutet, one of the researchers behind the study.

Toxins from mold found growing on nuts or corn can weaken the airways» self - clearing mechanisms and immunity, opening the door for respiratory diseases and exacerbating existing ones, suggests a study in Nature Scientific Reports published this month from otolaryngology researchers at the Perelman School of Medicine at the University of Pennsylvania.

here is epidemiological evidence that links type B coxsackie virus (CVB) infection with heart disease, and research published on July 31st in PLOS Pathogens now suggests a mechanism by which early infection impairs the heart's ability to tolerate stress at later stages of life.

Molecular microbiologists at the University of Southern California (USC) have uncovered intricate regulatory mechanisms within the cell that could lead to novel therapeutics for the treatment of cancer and other diseases.

«While these findings require further study into the mechanism that causes shingles patients to have an increased risk of heart attack and stroke, it is important that physicians treating these patients make them aware of their increased risk,» said Sung - Han Kim, MD, PhD, a physician in the department of infectious diseases at Asan Medical Center in Seoul and one of the study authors.

In this review topic, researchers looked at novel translational noise studies demonstrating the molecular mechanisms that may lead to impaired vascular function, recent epidemiologic evidence of noise - induced cardiovascular disease, and the non-auditory effects of noise and their impact on the cardiovascular system.

Researchers at the Boyce Thompson Institute (BTI) and Virginia Tech have discovered a new mechanism in the continual arms race between plants and pathogenic bacteria, which tomatoes use to detect the causal agent of bacterial speck disease.

«Pin1 changes protein shape through proline - directed phosphorylation, which is a major control mechanism for disease,» explains co-senior author Kun Ping Lu, MD, PhD, Director of Translational Therapeutics in the Cancer Research Institute at BIDMC and Professor of Medicine at Harvard Medical School who co-discovered the enzyme in 1996.

Researchers at the Sackler School of Graduate Biomedical Sciences at Tufts and Tufts University School of Medicine (TUSM) have uncovered a mechanism that may help explain the severe forms of schistosomiasis, or snail fever, which is caused by schistosome worms and is one of the most prevalent parasitic diseases in the world.

Where research uncovers possible mechanisms for disease, those working in drug discovery can use these data to develop novel diagnostic or monitoring tools, to develop therapies that address the biological pathways concerned, or to develop companion diagnostics to ensure that new — or existing — therapies are targeted at the correct subgroup of patients.

Djimdé leads a research group at the University of Science, Techniques and Technologies of Bamako that is working to understand how genome variation in the Plasmodium falciparum parasite, its human host, and the Anopeheles gambaie mosquito vector contribute to the mechanisms of malaria disease spread.

Isaiah Mansour, an undergraduate at the University of Maine, talks about how a Maine INBRE course on the molecular mechanisms of human disease at the MDI Biological Laboratory changed his life.

Vinetz said the next step will be to begin exploiting the genomic information «for vaccine and diagnostics development, experimental approaches to understanding mechanisms of disease pathogenesis and how Leptospira persist in the environment, all critical for developing new public health interventions aimed at reducing the global impact of this important but neglected zoonotic disease.»

In particular, the savvy scientists at the renowned Buck Institute for Research on Aging are devoted to geroscience, studying the mechanisms of aging and the connection between normal aging and chronic disease, in the institute's Novato labs.