Sentences with phrase «mechanistic insights of»

114/4: 15 Mechanistic insights of complex insertional translocations.

Not exact matches

In its encounter with the sciences, process thought has not only appropriated new scientific insights but has attempted a mutual transformation through which the sciences are liberated from the dominance of the mechanistic, deterministic, substantialist view into a holistic relational vision that is more coherent, consistent, adequate to the facts, and congruent with the best in the contemporary scientific enterprise itself.

Furthermore, interactions between the environment and the epigenome may provide mechanistic insight into many toxicological phenomena that are not well - understood, such as non-genotoxic carcinogenesis, age - based windows of susceptibility, developmental reprogramming by early life exposures, and trans - generational exposure effects.

«This work represents a mechanistic insight that could lead to the development of a new therapeutic approach for preventing asthma.»

«Having identified a link between cytoskeleton dynamics and Zika virus replication, together with the plethora of available cytoskeleton - targeting compounds, might contribute to gain mechanistic insight into the ZIKV replication cycle and identify new avenues for treatment,» Bartenschlager says.

«People still don't entirely know why gold - palladium is so selective,» Wilson added, but it seems that this new mechanistic insight will help to explain the selectivity of these materials.

Professor Wolf Reik, Head of the Epigenetics research programme, said: «Charting the different developmental timings in the early reprogramming events observed in the human and mouse - derived cells gives the first mechanistic insight into how these events are regulated which is tremendously exciting.

«Our structures of the complexes of the circadian clock proteins of cyanobacteria provided important mechanistic insights, but are static snapshots of a system that's continuously moving and changing hour by hour,» said LiWang.

As researchers gradually gain more insight into the genome's hierarchy of structures, they will get closer to figuring out how this macromolecular wonder works in all of its vastness and mechanistic detail.

Notophthalmus viridescens, an urodelian amphibian, represents an excellent model organism to study regenerative processes, but mechanistic insights into molecular processes driving regeneration have been hindered by a paucity and poor annotation of coding nucleotide sequences.

Analysis of Chemical and Biological Features Yields Mechanistic Insights into Drug Side Effects Miquel Duran - Frigola and Patrick Aloy Chemistry and Biology (2013): http://dx.doi.org/10.1016/j.chembiol.2013.03.017

This direct link between Exocyst and WRC complexes provides a novel mechanistic insight into the spatio - temporal regulation of cell migration.

«The data presented at AACR provide important new models and mechanistic insights that inform our planned development efforts to evaluate the ability of microbiome therapy to augment immune checkpoint inhibitors,» said David Cook, Ph.D., Chief Scientific Officer and Executive Vice President of Research at Seres.

Mechanistic Insights into Chemical and Photochemical Transformations of Bismuth Vanadate Photoanodes F. M. Toma, J. K. Cooper, V. Kunzelmann, M. T. McDowell, J. Yu, D. Larson, N. J. Borys, J. W. Beeman, F. A. Houle, K. A. Oersson, and I. D. Sharp

Together, the expected results will provide fundamental mechanistic insights into the structure and function of the newly discovered interbacterial nanotubes.

Fluorescence Cross-Correlation Spectroscopy Reveals Mechanistic Insights into the Effect of 2» - O - Methyl Modified siRNAs in Living Cells.

Our experiment provides new mechanistic insights into the role of memory systems in informing this process.

During her residency in Human Genetics at the University of Bonn she pursued her research interest both in immunology and human genetics by investigating expression quantitative trait loci (eQTLs), which underpin innate immune responses, and provide mechanistic insights to complement genome - wide association studies.

Previous work has given insights into the mechanistic pathways leading to small molecule sequestration in membrane - free coacervate protocells; successfully demonstrated the use of liquid - liquid phase separated micro compartments for protein expression using cell free expression systems; exploited microfluidics for the high throughput formation of stable, monodisperse microdroplets; and integrated two contrasting modes of protocell construction to produce a novel hybrid model based on fatty acid membrane - bound coacervate micro-droplets.

Our current studies therefore, are not only allowing us to investigate discrete interactions that lead to H. pylori - induced neoplasias but also are providing mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.

We want to gain comprehensive mechanistic insight into the division of human mitotic cells, provide a biophysical basis to understand nuclear organisation, and establish methods for systems analysis of the first mitotic divisions of mammalian embryos.

The lab investigates consequences of epigenetic alterations in neuronal cancers and neurodegenerative diseases using a combination of biochemistry, cell and molecular biology with genome wide approaches to gain mechanistic insight into how chromatin architecture is modified in disease.

As we demonstrate here, climate models provide new insights into the historical, current, and future populations of marine turtles and provide a mechanistic modeling framework for considering anthropogenic climate change.

Studying DNA methylation in the window of conception leads also to mechanistic insights into the spatio - temporal control of genomic methylation specificity, including components of histone modification and RNA - directed pathways (small and long).

Multiple types of spectroscopy and electron microscopy capabilities available at EMSL, the Environmental Molecular Sciences Laboratory, a DOE Office of Science user facility on the PNNL campus, allowed the scientists to understand the catalyst surface at the atomic level and provide mechanistic insight into how oxygen vacancies migrate to the surface of the cerium oxide, creating pathways for highly active carbon monoxide conversion.

I think that this investment has accelerated to the pace of research in the field of glaucoma; the number of publications that are really focusing on these mechanistic insights have just exploded in the last ten years, so this investment by Glaucoma Research Foundation was really a catalyst that allowed us to dig in deeper to understanding what's actually happening in the disease as the disease is progressing.

The ultimate goal of this line of investigation is to leverage these newly gained mechanistic insights for developing new therapeutics in a personalized manner based on one's unique genetic and / or pathway signatures.

Identifying a reliable signature pattern of altered RS activity for chronic pain could provide strong mechanistic insights and serve as a highly beneficial neuroimaging - based diagnostic tool.

74/4: 15 Functional analyses of type 2 diabetes - associated loci provides mechanistic insight into genetic susceptibility.

Such work yields unique mechanistic insight by directly illustrating the complex spatial - temporal dynamics of fundamental cellular processes such as mitosis, morphogenesis, polarization, embryonic development, membrane trafficking and cytoskeleton dynamics.

Probiotic strains and mechanistic insights for the treatment of type 2 diabetes.

A limitation of the insights from the energy balance is that they do not provide a closed mechanistic understanding of what controls the ITCZ position.

The article is interesting in my opinion since it gives some mechanistic insight on one of the many homeostatic temperature regulators.