Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.
The structures of membrane - bound BCL - 2 proteins have been long sought - after because they hold the keys for understanding
the mechanistic basis of activity and for the development of selective drugs free of off - target effects.
The mechanistic basis of decreased memory establishment secondary to enhanced TCR signaling is an area of ongoing investigation.
Regenerative medicine represents a new frontier in science, which seeks to understand
the mechanistic basis of tissue aging, repair, and regeneration and to leverage this knowledge to improve human health.
Not exact matches
I have a lot
of faith in science, not in the unscientific assumption that atheists make that reality is purely
mechanistic, but in the procedures
of testing hypotheses, questioning assumptions, measuring results, replicating experiments, and in general debating and persuading
based on actual evidence.
(11) The
mechanistic metaphor causes Westerners to regard cultures that live on the
basis of organic metaphors as «ignorant and confused.»
In this paper, I shall present a more adequate
mechanistic position
based on a contemporary image
of a machine and attempt to show its relationship to the ecological model
of Birch and Cobb.
The author presents a
mechanistic position
based on a contemporary image
of a machine and attempts to show its relationship to the ecological model
of Birch and Cobb, in which a classical mechanism is presented
based on an outdated image
of a machine.
Furthermore, interactions between the environment and the epigenome may provide
mechanistic insight into many toxicological phenomena that are not well - understood, such as non-genotoxic carcinogenesis, age -
based windows
of susceptibility, developmental reprogramming by early life exposures, and trans - generational exposure effects.
After thoroughly reviewing the accumulated scientific literature, a Working Group
of 22 experts from 10 countries convened by the IARC Monographs Programme classified the consumption
of red meat as probably carcinogenic to humans (Group 2A),
based on limited evidence that the consumption
of red meat causes cancer in humans and strong
mechanistic evidence supporting a carcinogenic effect.
Sweeney found that the
mechanistic answers that Pinker offered about the mind — the brain -
based mechanisms
of thought and consciousness being discovered by modern neuroscience — inspired her to replace her Catholic faith with science's empirical skepticism, which she finds, after many hilarious detours, «a much more powerful and reliable tool for understanding the world.»
«This is a unique approach to obtain personalized, predictive and
mechanistic descriptions
of people's physiology
based on their genetic and metabolic makeup,» said Palsson.
These findings also suggest a
mechanistic basis for potential treatments involving the painless electrical stimulation
of the amygdala, which are currently being studied in ongoing clinical trials.
«These results indicate that tamoxifen is a pharmacologically attractive scaffold for the development
of new anti-cryptococcal drugs and provide a
mechanistic base for its further optimization.»
The work, he says, «is really starting to give us some
mechanistic understanding
of the molecular
basis of evolution.»
Fourth, disease network analysis ultimately provides a
mechanistic basis for defining phenotypic differences among individuals with the same disease through consideration
of unique genetic and environmental factors that govern intermediate phenotypes contributing to disease expression.
An extension
of this model, however, proposes that EMT forms a key
mechanistic basis for the progression
of malignant tumors (reviewed by Nieto MA [1]-RRB-.
«Long - term projections
of the type presented here are always crude caricatures but I like this study because it does take a more
mechanistic approach
based on the known habitat requirements
of the species rather than using a more traditional and simplistic thermal envelope model,» he said.
When the mTORC1 (for «
mechanistic target
of rapamycin complex 1») pathway operates properly, it senses the amount
of nutrients, specifically amino acids, available and restricts cell growth
based on that level.
The symposium brings together leaders in biology, medicine, and industry to present on the latest advances in technology development,
mechanistic understanding, and therapeutic application
of stem cells for both drug development and cell -
based therapy.
Our research programme is highly interdisciplinary, using the tools
of chemical physics to understand the chemical
basis for complex biological and
mechanistic problems.
Previous work has given insights into the
mechanistic pathways leading to small molecule sequestration in membrane - free coacervate protocells; successfully demonstrated the use
of liquid - liquid phase separated micro compartments for protein expression using cell free expression systems; exploited microfluidics for the high throughput formation
of stable, monodisperse microdroplets; and integrated two contrasting modes
of protocell construction to produce a novel hybrid model
based on fatty acid membrane - bound coacervate micro-droplets.
The successful candidate will provide expertise to assess the human safety
of Unilever ingredients within multidisciplinary teams developing & applying novel,
mechanistic / pathways
based approaches.
We want to gain comprehensive
mechanistic insight into the division
of human mitotic cells, provide a biophysical
basis to understand nuclear organisation, and establish methods for systems analysis
of the first mitotic divisions
of mammalian embryos.
The proposal,
based on published experimental results and a validated computer simulation
of neural networks, derives its
mechanistic framework from the intimate connection in mindfulness between mind and body, since standardized mindfulness meditation training begins with a highly localized focus on body and breath sensations.
Finally, due to the
mechanistic nature
of the climate forcing models, we project historical and future nesting trajectories
based on available climate data and under different climate change scenarios.
From these cell
based and clinical studies, we have developed important
mechanistic ideas such as activation
of protein kinase C, the role
of vascular endothelial growth factor (VEGF) and selective insulin resistance as some
of the basic mechanisms for the pathogenesis
of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.
The ultimate goal
of this line
of investigation is to leverage these newly gained
mechanistic insights for developing new therapeutics in a personalized manner
based on one's unique genetic and / or pathway signatures.
Identifying a reliable signature pattern
of altered RS activity for chronic pain could provide strong
mechanistic insights and serve as a highly beneficial neuroimaging -
based diagnostic tool.
These data define a critical role for MORC2 in epigenetic silencing by the HUSH complex and provide a
mechanistic basis underpinning the role
of MORC2 mutations in CMT disease.
Knowledge gained from
mechanistic studies may contribute to the design
of allogeneic vaccine -
based or adoptive immunotherapy for breast cancer.
My group has explored the
mechanistic and quantitative
basis of variation in these signals, as well as how they are used in communication and respond under varied selective regimes.
[D] espite the strong
mechanistic or physiological
basis for a role
of warming in coral bleaching and coral growth, a robust demonstration
of a direct causal link between global warming and global coral bleaching over decadal time scales has not yet been produced.»
Other publications on cancer chemoprevention include Comprehensive review
of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials, Chemopreventive effects
of natural dietary compounds on cancer development, Organosulfur compounds in cancer chemoprevention, Cancer prevention by natural compounds, Cruciferous vegetables and cancer prevention, Cruciferous vegetables and human cancer risk: epidemiologic evidence and
mechanistic basis, Cruciferous vegetables: cancer protective mechanisms
of glucosinolate hydrolysis products and selenium.
Despite these cautions, the data on the relationship between Dietary Fiber intake and risk
of CHD
based on epide - miological, clinical, and
mechanistic data are strong enough to warrant using this relationship as a
basis for setting a recommended level
of intake.
In phony merit pay — the kind that hardly exists in any industry — there is a
mechanistic calculation
of performance that determines the size
of a small bonus that is provided in addition to a
base salary that is essentially guaranteed regardless
of performance.
Further, Tanner points out that the 1920s was a time period when much
of the research on intelligence was
mechanistic and heavily
based on eugenics, whereas the critical factor is environmental.
His ideas were marked by a
mechanistic materialist foundation, a characterization
of human nature
based on greed and fear
of death, and support for an absolute monarchical form
of government.
(2) In my view, there are very likely strong
mechanistic links between the outcomes
of Bob's analyses (briefly noting that most
of his historic data is
based on shipboard measurements) and the biophysical effects I am referring - to — especially from the later 20th century to now.
We don't know that for a fact in the real data, but to believe that they do on the
basis of thinking you see such patterns (and with no reasonable
mechanistic explanation) is sort
of like continuing to believe Yuri Geller can bend spoons with his mind after James Randi has clearly demonstrated how he can just as convincingly bend spoons using slight -
of - hand.
The Guidance Note for Lead Authors
of the IPCC Fifth Assessment Report on Consistent Treatment
of Uncertainties impose upon the lead authors to assign subjective levels
of confidence to their findings: «The AR5 will rely on two metrics for communicating the degree
of certainty in key findings: 1 Confidence in the validity
of a finding,
based on the type, amount, quality, and consistency
of evidence (e.g.,
mechanistic understanding, theory, data, models, expert judgment) and the degree
of agreement.
Projections
of key variables in a realistic model should not be
based on
mechanistic temporal extrapolations
of those variables but rather on the intrinsic internal dynamics
of the system.
In particular, in the face
of uncertain coupling
of natural and anthropogenic climate forcing, understanding the timing, extent and especially the
mechanistic basis for baseline shifts now represents an urgent challenge.