Not exact matches
But now «the
approach can be reset using the bacterial and human
genomic data,» says immunologist Steven Schutzer of the University of
Medicine and Dentistry of New Jersey.
«To realize the benefits of the most recent progress in cancer
genomics, clinical implementation of precision
medicine approaches is needed in the form of novel biomarker assays.
«Using innovative data normalization and gene selection
approaches, we combined the statistical power of multiple
genomic studies and masked their variability and batch effects to identify robust early diagnostic biomarkers of pancreatic cancer,» said first author Manoj Bhasin, PhD, Co-Director of BIDMC's Genomics, Proteomics, Bioinformatics and Systems Biology Center and Assistant Professor of
Medicine at HMS.
It is widely known that
genomics has already begun to influence
medicine and that bioinformatics holds the key for developing new medical
approaches, but how does medical
genomics really work?
Highlight best practices and lessons learned to enable others to effectively implement
genomic medicine approaches
September 5, 2013 — The
Genomic Medicine Institute hosted a genetics education symposium, «Genetics and Genomics: Roadmap for Clinical Practice,» at the InterContinental Hotel in Cleveland.The learning objectives of this continuing medical education (CME)- accredited event included discussing practical
approaches for diagnosing, evaluating and managing patients with common genetic disorders, exploring the role of clinical genetic counselors as members of the healthcare team, and analyzing unique genetic cases from various specialties.
The study, integration and analysis of these data increasingly allows to unravel the genetic mechanisms and networks underlying complex biological phenotypes paving the way for an era of «
genomic medicine,» in which new diagnostic and therapeutic
approaches to common multifactorial conditions are emerging.
In particular, I have initiated a team
approach that is identifying and studying recurrent, treatment - refractory cancers in our clinics using these
approaches as a component of evidence - based diagnostic
medicine, seeking to better understand the
genomic drivers in these cancers and to identify novel treatment
approaches that target them, in hopes of obtaining durable responses.
Economic Modeling: Our economic modeling core, led by Dr. Ann Wu, uses a variety of modeling
approaches to project the medical and financial consequences of
genomic medicine, including the use of pharmacogenomic testing to inform medication choices and the use of sequencing as an adjunct to standard newborn screening.