Sentences with phrase «medicine say a protein»

Not exact matches

Most groups have focused on detecting proteins released from dying brain cells, but those proteins are not always abundant after injury and often require exotic or proprietary antibodies to measure, said study corresponding author Adam Chodobski, associate professor (research) of emergency medicine in the Alpert Medical School of Brown University.

The drug - like compounds can be modified and developed into medicines that target a protein in the human body that is responsible for chemotherapy resistance in cancers, said biochemist Pia D. Vogel, lead author on the scientific paper reporting the discovery.

This study suggests that standard dietary advice for uric acid reduction which is to reduce alcohol and protein intake, should now include advice to adopt the DASH diet,» says senior author Edgar R. Miller III, M.D. Ph.D., professor of medicine at the Johns Hopkins University School of Mmedicine at the Johns Hopkins University School of MedicineMedicine.

The protein puts the immune system's brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study's principal investigator and a professor of medicine in the division of hematology - oncology at the David Geffen School of Medicine medicine in the division of hematology - oncology at the David Geffen School of Medicine Medicine at UCLA.

«Considering that PDPN is associated with poor prognosis in GBM, CAR T - cell therapy that targets this protein is promising for treatment of patients with relapsed or resistant tumors following first - line chemotherapy,» says Toshihiko Wakabayashi, a coauthor and the chair of Department of Neurosurgery Nagoya University School of Medicine.

«Compared to other proteins that have been measured in traumatic brain injury, BDNF does a much better job of predicting outcomes,» says Frederick Korley, M.D., Ph.D., an assistant professor of emergency medicine at the Johns Hopkins University School of Medicine and first author of the nemedicine at the Johns Hopkins University School of Medicine and first author of the neMedicine and first author of the new paper.

«Asthma patients are constantly firing through this pathway because those proteins are stuck in the «on» position, without proper control by other proteins that shut down this reaction,» says Nicola Heller, Ph.D., assistant professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Mmedicine at the Johns Hopkins University School of MedicineMedicine.

Co-author Peter H. R. Green, MD, the Phyllis and Ivan Seidenberg Professor of Medicine and director of the Celiac Disease Center at Columbia University Medical Center, said, «These results indicate that immunologic reactivity in celiac disease may not be limited to wheat gluten, but can involve certain non-gluten proteins, too.

But down the road, Baker says, the new designer protein could serve as the basis for a cheap diagnostic — akin to a pregnancy test — for detecting flu and possibly even medicines able to knock it out.

At the University of Southern California, researchers have isolated the two proteins in the Zika virus that seem to be the culprits «that block normal fetal brain development,» says Jae Jung, the study's lead author and a microbiologist at USC's Keck School of Medicine.

«We were very surprised to find alterations in proteins that are responsible for RNA splicing in Alzheimer's, which could have major implications for the disease mechanism,» says Allan Levey, MD, PhD, chair of neurology at Emory University School of Medicine and director of the Emory ADRC.

Moreover, the results may transcend the bloating and discomfort of lactose intolerance: The technique could serve as a way to transform the gut lining into a factory for replacing missing proteins in other genetic disorders such as hemophilia, says pulmonologist Eric Alton of the Imperial College School of Medicine in London.

«We hypothesize that having such a long glutamine repeat causes the protein to fold improperly,» says Huda Zoghbi, a molecular geneticist at the Baylor College of Medicine in Houston.

«The challenge that remains is if there are many proteins interacting with the huntingtin protein, we can not easily determine which are relevant for disease and which are not,» said Erich Wanker from Max Delbrück Center for Molecular Medicine and corresponding author of the study.

These proteins work like ID cards, says study coauthor Joseph Dougherty, a neurogeneticist at Washington University School of Medicine in St. Louis.

«In our human airway epithelial model system, one of the drugs destabilizes and deactivates the protein that the other drug tries to correct,» said Martina Gentzsch, PhD, an assistant professor of cell biology and physiology and senior author of the UNC Science Translational Medicine paper.

«Since then people have been looking for the protein [the gene makes], but have had no luck,» says microbiologist Nigel Fraser at the University of Pennsylvania School of Medicine.

«Proteins are becoming more and more widely used in various consumer products, from GMOs to therapeutic medicines,» Fitzgerald said.

«Our understanding of protein structure, the virus and the virus life cycle is allowing us to do things that we didn't think was possible even a few years ago,» says Gary Nabel, chief scientific officer at drugmaker Sanofi and an author on the Nature Medicine paper.

«The PSA test is based on the fact that men with higher levels of the PSA protein are more likely to have prostate cancer,» said William Catalona, MD, principal investigator on the Prostate Health Index clinical study and urologist at Northwestern Medicine and director of the Clinical Prostate Cancer Program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, where they began using the phi test on patients in February.

«We found that women who lost weight eating a high - protein diet didn't experience any improvements in insulin sensitivity,» said principal investigator Bettina Mittendorfer, PhD, a professor of medicine.

«Telomeres, the protein caps on the ends of human chromosomes, are markers of aging and overall health,» said Naruhisa Yamaki, M.D., a clinical fellow at the Kobe University Graduate School of Medicine.

«In most protein conformational disorders, there is a particular protein that is the key culprit,» said Dr. Buhimschi, who also is a tenured professor at The Ohio State University College of Medicine.

«This is the first time that this specific protein - protein signaling complex has been identified in GBM, and it gives us a new potential target for drug development,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, professor and chair of the Department of Human and Molecular Genetics at the VCU School of Medicine, and director of the VIMM.

Indeed, exposure of the protein produced by the nanoparticle - based gene therapy to the gut mucosa prevents inhibitor development and restores clotting - factor activity in mouse models of both haemophilia A and B. «This approach really could hold big benefit for patients,» says Jörg Schüttrumpf, a transfusion - medicine specialist who led one of the studies performed at the German Red Cross Blood Donor Service in Frankfurt.

«Cancer is essentially a disease of mutated or broken genes, so that motivated us to examine whether circular RNAs, like proteins, can be affected by these chromosomal breaks,» said senior author Pier Paolo Pandolfi, MD, PhD, Director of the Cancer Center at BIDMC and George C. Reisman Professor of Medicine at Harvard Medical School.

«Recent advances in chemical protein synthesis make it more feasible to produce larger synthetic D - proteins,» says Michael S. Kay, M.D., Ph.D., professor of biochemistry at the University of Utah School of Medicine and senior author of the study.

«Current antiretroviral drugs target HIV's proteins,» says James Stivers, Ph.D., a professor of pharmacology and molecular sciences at the Johns Hopkins University School of Medicine, «but those proteins are moving targets because they are often altered by mutations.

Both anemia and low hemoglobin levels, which are proteins in red blood cells that carry oxygen throughout the body, are also common in older people, said Phyo Myint, M.D., senior study author and Professor of Medicine of Old Age at the University of Aberdeen in Scotland.

«We found that MYSM1 creates access to proteins that enhance gene transcription and, ultimately, the maturation of natural killer cells themselves,» said Vijayalakshmi Nandakumar, a Ph.D. student at the Keck School of Medicine of USC and the study's first author.

The newly expanded genetic alphabet, Thyer says, should yield a vastly more diverse menu of proteins with a wide variety of new chemical functions, such as medicines better able to survive in the body and protein - based materials that assemble themselves.

In the future, he says, the ability of RASFs to invade cartilage could even be turned to medicine's advantage by reprogramming them, perhaps with gene therapy, to deliver proteins that heal the joint instead of demolishing it.

«Because the hematopoetic stem cell niche is so important for the creation of bone marrow and blood cells and because Del - 1 is a soluble protein and is easily manipulated, one can see that it could be a target in many potential applications,» said George Hajishengallis, the Thomas W. Evans Centennial Professor in the Department of Microbiology in Penn's School of Dental Medicine and a senior author on the work.

«We are taking several experimental approaches to identify the Mtb genes and proteins that are involved in this process,» said Dr. Vidhya Nair, study lead author and a postdoctoral researcher in Internal Medicine.

«Thousands of messenger RNAs reside in dendrites, yet the dynamics of how multiple dendrite messenger RNAs translate into their final proteins remain elusive,» says James Eberwine, PhD, professor of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, and co-director of the Penn Genome Frontiers Institute.

«Our data shows that SIRT1 is a protein that is required to maintain the health of blood stem cells and supports the possibility that reduced function of this protein with age may compromise healthy aging,» says Saghi Ghaffari, MD, PhD, Associate Professor of Developmental and Regenerative Biology at Mount Sinai's Black Family Stem Cell Institute, Icahn School of Medicine.

«Identifying the rogue proteins of cancer is an important pathway toward developing new drugs,» said co-author R. Reid Townsend, MD, PhD, a professor of medicine and director of the Proteomics Shared Resource at Washington University.

«The high protein diet that has been used increasingly in recent years to control weight gain and obesity may have deleterious impacts on kidney health in the long term,» said Kalantar - Zadeh, director of the Harold Simmons Center of Kidney Disease Research and Epidemiology, and chief of the Division of Nephrology and Hypertension, UC Irvine School of Medicine.

Abnormal levels of the proteins may be useful biomarkers that could help us study early treatments to limit or reverse the damage to brain cells and even prevent the development of the full - blown disease,» said study author Edward Goetzl, MD, a Professor of Medicine with the University of California, San Francisco, a researcher at the National Institute on Aging, and a scientist of NanoSomiX, Inc., a California - based biotechnology company that provided a grant for method development for the study.

«In our study, women's muscle appeared more efficient in neutralizing this protein, and this allows insulin to work better to move sugar from circulation to muscle,» said lead author Dr. M. Constantine Samaan, assistant professor of pediatrics at the Michael G. DeGroote School of Medicine and pediatric endocrinologist at the McMaster Children's Hospital

«We can now design synthetic proteins that are far more sophisticated than natural ones, and use such super-performance proteins toward advancing science and medicine,» he said.

Even if mutations are rare, however, locating a gene and its associated protein, says cardiologist Douglas Zipes of the Indiana University School of Medicine in Indianapolis, «will give a major advantage» to researchers trying to unravel the biochemical triggers of the erratic electrical signals in all patients.

«People with cystic fibrosis have an imbalance of salt in their bodies caused by the defective CFTR protein,» said Talissa Altes, M.D., chair of the Department of Radiology at the MU School of Medicine and lead author of the study.

It included a 1994 report from the Institute of Medicine that said it was biologically plausible for a vaccine to «induce... an autoimmune response... by nonspecific activation of the T cells directed against myelin proteins.»

The genes involved encode proteins that control the activity of a very important and ubiquitous class of molecules that are a major target of pharmacologic agents across medicine,» says Ethan Goldberg, MD, PhD, an attending physician and instructor of neurology at the Children's Hospital of Philadelphia and The Perelman School of Medicine at The University of Pennsmedicine,» says Ethan Goldberg, MD, PhD, an attending physician and instructor of neurology at the Children's Hospital of Philadelphia and The Perelman School of Medicine at The University of PennsMedicine at The University of Pennsylvania.

«If we want to create better medications, the first step is to see what the D2 receptor looks like in high - resolution detail when it's bound tightly to a drug,» said senior author Bryan L. Roth, MD, PhD, the Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics at the UNC School of Medicine.

«This is quite good and convincing work that confirms host defense activity of amyloid - β against fungal and bacterial infections in animal models, and begins to unravel the mechanisms of antimicrobial activity of the protein,» said Kevan Hartshorn who studies innate immunity at the Boston University School of Medicine and was not involved in the study.

Studies in cells and genetically modified mice show that the regulatory subunit of the PI 3 - kinase, a protein called p85, works both ways, says C. Ronald Kahn, M.D., Head of the Joslin Section on Integrative Physiology and Metabolism, and senior author on a Nature Medicine paper reporting the discovery on March 28.

«We found that the immune system in a large group of patients reacted to a protein formed only in the prostate, namely the enzyme transglutaminase 4,» says lead investigator Dr Nils Landegren at SciLifeLab, Department of Medical Sciences at Uppsala University and Karolinska Institutet's Department of Medicine in Solna.

«Two months post-transplantation, we noticed a boost in human liver protein levels, an indication the transplanted cells were becoming mature,» says Saiyong Zhu, PhD, a Postdoctoral Scholar at Gladstone and the California Institute for Regenerative Medicine who was among the study's lead authors.