The 14th International Congress of the Society for
Melanoma Research which this year was a joint meeting with the 9th World Congress of Melanoma was held in Brisbane, Australia, from 18th to the 21st October, 2017.
Not exact matches
A Ludwig Cancer
Research study led by Benoit Van den Eynde, Director of Ludwig Brussels, has identified a novel mechanism by
which tumors of the aggressive skin cancer
melanoma can resist cancer immunotherapy.
The work published in Cancer Cell complements previous
research efforts from the CNIO
Melanoma Group,
which could lead to the development of novel drugs that selectively target the mechanism of cell autodigestion as a potential therapeutic strategy.
The new
research,
which studied the immortalization process using genome - engineered cells in culture and also tracked skin cells as they progressed from a mole into a malignant
melanoma, suggests that telomerase plays a more complex role in cancer.
Research from Rutgers Cancer Institute of New Jersey shows that the RUNX2 protein,
which regulates the transcription of genetic messages responsible for the different functions of cells, may play a role in
melanoma cell growth and spread and could serve as a therapeutic target for the disease.
«We have found that the individual cells within
melanoma tumors are not all identical, and tumors contain a sub-population of cells that are inherently drug resistant, which accounts for the fact that advanced melanoma tumors return no matter how much the tumor is depleted,» said Meenhard Herlyn, D.V.M., D.Sc., professor and director of Wistar's Melanoma Research
melanoma tumors are not all identical, and tumors contain a sub-population of cells that are inherently drug resistant,
which accounts for the fact that advanced
melanoma tumors return no matter how much the tumor is depleted,» said Meenhard Herlyn, D.V.M., D.Sc., professor and director of Wistar's Melanoma Research
melanoma tumors return no matter how much the tumor is depleted,» said Meenhard Herlyn, D.V.M., D.Sc., professor and director of Wistar's
Melanoma Research
Melanoma Research Center.
«We need to confirm this synergistic activity of vemurafenib and cediranib across a broader range of
melanoma models, investigate why the particular combination is effective, and find biomarkers that predict
which patients with BRAF - mutant
melanoma should receive this combination,» says Friedman, who is a
research fellow in Dermatology at Harvard Medical School.
Dr Andreas Behren, who led the ONJCRI
research team, said that although extremely rare, it couldn't be predicted
which melanoma patients might develop other cancers as a result of their treatment.
Faculty and governmental relations leaders in the
Melanoma Moon Shot and the Cancer Prevention and Control Platform provided educational information about indoor tanning and cancer risk to Texas legislators and served as the primary clinical and
research resources on the Texas prohibition law,
which took effect in September 2013.
Between 2005 and 2011 GenoMEL was funded under the EU's Sixth Framework Programme (FP6) to the tune of $ 10.45 million, however in recent years GenoMEL has continued to evolve, giving rise to BioGenoMEL (a daughter consortium focusing on understanding the genetics of survival from
melanoma) and most recently the MELGEN consortium
which itself is funded by a $ 4.8 million grant through the European Union's Horizon 2020
research and innovation programme under grant agreement No 641458.
The second session focused on
melanoma susceptibility genes featuring the
research of ESR03, Marina Juraleviciute, on MX2, a gene identified as a
melanoma suscepitlity gene by the GWAS consortium; and ESR01, Aravind Sankar, who discussed the finctional effect of gene mutations
which contribute to
melanoma development.
GenoMEL
research carried out to identify new inherited genes
which increase the risk of
melanoma
The international
melanoma genetics consortium GenoMEL (www.genomel.org) has carried out
research to identify inherited genetic variation
which increases risk of
melanoma, and on their website there are summaries of the results of that
research.
The
research published by GenoMEL has identified inherited genes
which increase
melanoma risk
which are pigment genes (affecting skin colour and vulnerability to sunburn), genes
which are associated with having more moles (melanocytic naevi) and others associated with a part of the genetic makeup of the cell called the telomere.