Sentences with phrase «merkel cell progenitors»

Dr. Alicia Melendez, a biologist at Queens College, City University of New York (CUNY), and her colleagues report in Current Biology that autophagy is important for the proliferation of stem cells, specifically for promoting the cell cycle of stem cell progenitors.

Further tests suggested that epithelial cell progenitors helped by restoring the connection between cells called myoepithelial contractile cells and the lacrimal gland's secretory cells, which produce tears.

The researchers knew they faced a major challenge: sorting and separating «sticky» epithelial cell progenitors without destroying them.

«They answered key questions, and it became clear that this is not just a brain disease or a peripheral nerve disease; in fact, this spoke to some kind of neural stem cell progenitor problem,» said Lupski.

B.J. Fowlkes, Bonnie J. Mathieson, and colleagues identify CD4 and CD8 double - negative cells in the adult thymus as the earliest recognizable T cell progenitors.

We found that these β - cell progenitors experience different levels of Notch signaling, which in turn regulate distinct cellular outcomes.

WIKIMEDIA, CSIROAfter human somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs), the resulting cells retain both genetic and epigenetic indicators of the age of the person who donated the somatic - cell progenitors, scientists have found.

Our therapy is based on pancreatic beta cell progenitors (Pro-Islet (TM)-RRB- derived from human pluripotent stem cells.

May 25, 2000 Different levels of transcription factor coax immune cell progenitors down different developmental pathways Researchers from the University of Chicago provide evidence that varying levels of a single transcription factor can determine the fates of developing cells.

The Company's technology is based on pancreatic beta cell progenitors derived from human pluripotent stem cells.

Our therapy is based on the encapsulation and implantation of pancreatic beta cell progenitors (Pro-Islet-1) derived from human stem cells which secrete insulin in patients.

Writing in Journal of Immunology, lead author and BSI member, Professor Graham Anderson explains, «Post-transplantation, T - cell progenitors derived from the bone marrow transplant can struggle to enter the thymus, as if the doorway to the thymus is closed.

They found that Lymphotoxin β receptor, a cell surface molecule, controls the entry of T - cell progenitors to the thymus, both in a healthy state and during immune recovery following bone - marrow transplantation.

Then Hu expressed lincRNA - EPS in maturing red blood cells and grew these cells in the absence of the hormone erythropoietin, which normally prevents the blood cell progenitors from undergoing apoptosis.

Not exact matches

It's blood in a newborn baby's umbilical cord that's rich in a type of stem cell called hematopoietic progenitor cells (HPCs).

Transient Silencing of 14 -3-3sigma promotes proliferation of p63 - positive progenitor cells isolated from human breastmilk in mammary epithelial cell culture.

After 20 years developing their method, they say they can turn the progenitor cells that are inside seminiferous tubules, called spermatogonia, into mature sperm.

«We've shown that SIF - seq can be used to identify enhancers active in cardiomyocytes, neural progenitor cells, and embryonic stem cells, and we think that it has the potential to be expanded for use in a much wider variety of cell types,» Dickel says.

Institute researchers also uncovered the parents (called progenitors) that produce dendritic cells.

«What's really exciting about this was that the activity differences were detected at a critical time in brain development: when neural progenitor cells are proliferating and expanding in number, just prior to producing neurons,» Silver said.

The overlap in gene expression changes when neural progenitor cells are infected by African or Asian strains of Zika virus.

Targeting progenitor cells could make treatments more efficient, Dr Ginhoux said.

Scientists have revealed molecular differences between how the African and Asian strains of Zika virus infect neural progenitor cells.

«There are currently no therapies which successfully reverse the damage seen in the more than 12,000 individuals who suffer a spinal cord injury each year in the United States alone,» says Dr. Richard G. Fessler, professor of neurological surgery at Rush University Medical Center and principal investigator for the Phase 1 clinical trial involving AST - OPC1 (oligodendrocyte progenitor cells).

The findings, from the Emory / Johns Hopkins / Florida State team that showed this spring that neural progenitor cells are particularly vulnerable to Zika infection, were published in Nucleic Acid Research.

The neural progenitor cells used were derived from iPSCs (induced pluripotent stem cells), which were in turn derived from donor skin cells.

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

Although they show that dengue can infect neural progenitor cells like Zika can, dengue infection does not stunt the cells» growth or lead to cell death.

«Suppressing a progenitor from creating the subtype of dendritic cells implicated in causing lupus, for example, could be an efficient way of treating autoimmune diseases while minimising the impact on the rest of the immune system.

Both Zika strains were able to infect and cause cell death in neural progenitor cells.

«One progenitor cell can produce multiple daughter cells,» he said.

We were able to show that progenitor cells in our model and in patients with essential thrombocythemia, had a signature of excessive thrombopoietin stimulation.

By using genetic «signatures», we were able to compare the blood progenitor cells responsible for overproducing megakaryocytes in our model, to progenitor cells in people with essential thrombocythemia.

«Thrombopoietin signals actually acted on stem cells and progenitor cells, several generations back.»

This type of stem cell, called an oligodendrocyte progenitor cell, is found in the brain and spinal cord.

But it was another three decades before Klassen — who has used retinal progenitor cells to restore vision in mice, cats, dogs and pigs — could conduct human trials involving retinitis pigmentosa.

In June 2015, she became the first patient in North America to receive an eye injection of about half a million retinal progenitor cells.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

This is because larger brain parts are thought to have a later and longer process of neurogenesis — the development of neurons or nerve cells from neural stem cells and progenitor cells.

To create an egg, a progenitor cell called an oocyte divides into two daughter cells: a hulking egg cell and a wimpy polar body.

These drugs sensitize cancer cells to alternative treatments and stave off progenitor cells that could prevent cancer relapse.

An example of epigenetic modifications leading to cancer progenitor cell formation possibly occurs in leukemia development.

«Esophageal cancer «cell of origin» identified: In mice, basal progenitor cells give rise to Barrett's esophagus, a precursor to cancer.»

The same observations were made in organoids (artificially grown masses of cells that resemble an organ) created from unique basal progenitor cells that were isolated from the gastroesophageal junction in mice and humans.

«All of the known cells in this tissue remained the same, but we found a previously unidentified zone populated by unique basal progenitor cells,» he said.

«Recent studies suggest that epigenetic modifications may contribute to the development of cancer progenitor cells that can induce drug resistance and the relapse of different types of cancer,» said Sibaji Sarkar, PhD, instructor of medicine at BUSM.

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

Human hematopoietic stem and progenitor cells (HSPCs), derived from bone marrow, have become a primary vehicle for efforts to replace or regenerate cells destroyed by a variety of diseases.

These progenitor cells are often drug resistant and can initiate cancer development and are possibly involved in cancer relapse.

Studies in cancer patients indicate reduced rates of relapse when patients are pretreated with epigenetic drugs due to its far - reaching capabilities; killing progenitor cells at the site of the tumor, in circulation, or at a distant site.