Sentences with phrase «metastatic breast»
"Metastatic breast" refers to a stage of breast cancer where cancer cells have spread or spread beyond the breast to other parts of the body. It means that the cancer has advanced, moving from the original tumor to other organs such as the bones, liver, lungs, or brain. Full definition
Low levels of a tiny RNA fragment in cells are associated with metastatic breast cancer in humans and increases the aggressive spread of breast cancer in mice, according to researchers at Whitehead Institute for Biomedical Research.
wi.mit.edu
In addition, a drug called dexrazoxane that could reduce cell damage has recently been approved for patients with metastatic breast cancer who receive high doses of doxorubicin.
Treatment in a mouse model of metastatic breast cancer with two of the down - regulated miRNAs (miR - 141 and miR - 219) suppressed bone metastases, suggesting that these miRNAs may have therapeutic utility.
To identify the pathways affected by the inactivation of the ABL kinases in metastatic breast cancer cells, we carried out Gene Set Enrichment Analysis (GSEA) using multiple databases (37).
Treatments vary widely for metastatic breast cancer patients, though an analysis suggests that costs per patient are relatively similar across a number of different treatments.
Palbociclib in Combination with Fulvestrant or Tamoxifen as Treatment for Hormone Receptor - Positive Metastatic Breast Cancer with Prior Chemotherapy for Advanced Disease: A Phase II Study with Pharmacodynamic Markers (TBCRC035)
Although the work is at the first stage of development, it excites team leader David L. Spector, Ph.D., because in mouse models of human metastatic breast cancer it has produced «differentiation of an aggressive primary tumor, redirecting it from a highly proliferative state, and reducing its metastatic activity by 70 percent.»
Together, our data suggest that clinical studies may be warranted to evaluate the therapeutic potential of ABL allosteric inhibitors and to determine whether combination therapies that incorporate these compounds are effective in treating metastatic breast cancer.
Expanded approval given to cancer drug; Drug now approved to treat patients with certain metastatic breast cancers FDA approves first treatment for breast CPM Educational Program is a California nonprofit 501 (c)(3) corporation dedicated to improving grades 6 - 12 mathematics instruction.
In this report, we found that CSCs (CD24 − / CD44 + / ESA +) isolated from metastatic breast cell lines are significantly more metastatic than non-CSC populations in an organ - specific manner.
Such a therapeutic platform has significant clinical implications for improving the treatment of metastatic breast carcinoma and other malignant solid tumors.
With the recent success of identifying selective inhibitors targeting CSCs, we believe that the newly isolated cycling hypoxia - selected subpopulation may present a new opportunity for chemical screening and discovery of compounds with selective toxicity for metastatic breast CSCs.
Ottawa, Canada About Blog Focusing on the little details of life after metastatic breast cancer, Laurie Kingston's charming blog is a great glimpse into her life as a mother and writer in Canada.
This is called metastatic breast cancer.
Enter a genomics project focused on metastatic breast cancer that aims to fill some of those data gaps.
Identification of a stem - like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation
Though surgery and eight months of chemotherapy treatment put her in remission for years, Newton - John is now battling metastatic breast cancer that has spread to her sacrum, or lower spine.
To identify factors that distinguish the malignant subpopulation within breast tumors, we began to explore environmental influences known to associate with aggressively metastatic breast tumors.
A Phase Ib Trial of LY2157299 (TGFβR1 Kinase Inhibitor) with Paclitaxel in Patients with Triple Negative Metastatic Breast Cancer
Our results demonstrated the possibility of isolating highly metastatic breast CSCs using the hypoxia / reoxygenation regimen we established.
We'll test this in other models — with other classes of drug and in mice with a cancer that mimics metastatic breast cancer, for example.»
Until now, little research has been done into how metastatic brain tumors develop, but previous mouse experiments that imaged metastatic breast cancer cells over time have shown that of those cancer cells that do make it to the brain, fewer than one in 1,000 survive.
Analysis of blood samples taken at several points in time from a group of patients with different forms of advanced metastatic breast cancer found CTC clusters in the blood of 35 percent of patients and that the survival of those with more clusters in their blood was significantly reduced.
«Protein keeps metastatic breast cancer cells dormant: Research reveals one of the mechanisms that allows metastatic cells to leave a latent state.»
These results show the power of genetic sequencing in understanding metastatic breast cancer and open the door to personalised treatment for breast cancer in the future.»
This may explain why metastatic breast cancer is currently difficult to treat.
In work published this week in Cell, Tavazoie and his colleagues describe how fluctuations in the amount of tRNAs can have a dramatic impact not only on the fate of a single cell, but also on diseases like metastatic breast cancer.
«Scientists identify bone degradation process within metastatic breast cancer: Phase 1 clinical trial shows promising results with new drug.»
NEW HOPE AGAINST RESISTANT BREAST CANCER: Ixabepilone, a compound being investigated by Bristol - Myers Squibb, shows some encouraging effectiveness against metastatic breast cancers that are resistant to three other standard chemotherapy drugs (anthracycline, taxane and capecitabine).
A doctor treating a patient with a potentially fatal metastatic breast tumor would be very pleased to find, after administering a round of treatment, that the primary tumor had undergone a change in character — from aggressive to static, and no longer shedding cells that can colonize distant organs of the body.
PHIb Trial of Fulvestrant, Palbociclib (CDK4 / 6 inhibitor) and Erdafitinib (JNJ - 42756493, pan-FGFR Tyrosine Kinase Inhibitor) in ER + / HER2 - / FGFR - amplified Metastatic Breast Cancer (MBC)
Mertz is also Midwest coordinator for the national Metastatic Breast Cancer Network.
Why do some people get metastatic breast cancer at a young age?
Vinflunine did not improve overall survival compared with physician's choice of alkylating agent in patients with heavily pretreated metastatic breast cancer.
The intent of our research into metastatic breast cancer is to improve the treatments available to patients with this disease, to increase their chance of long - term survival and, ultimately, to reduce the burden of metastatic disease by preventing its occurrence.
To investigate whether inhibition of ABL kinases interferes with metastatic processes other than invasion, we depleted ABL1 and ABL2 (ABL1 / ABL2) in two bone metastatic breast cancer cell lines, 1833 and SCP28 (22), and evaluated the metastatic potential of these cells after intracardiac injection into immunodeficient mice.
We have established a technique to generate syngeneic murine metastatic breast cancer model that mimic human breast cancer progression (Rashid OM et al, Breast Cancer Research and Treatment 2014).
Under the guidance of a world - renowned cancer biologist, Robert Weinberg, Ph.D., Lu is focusing on how metastatic breast cancer cells interact with a subset of immune cells called macrophages, which normally are capable of engulfing — literally eating — infected, damaged, or cancerous cells.
When you have breast cancer, especially metastatic breast cancer — where the disease has spread to other areas of your body and becomes a kind of terrible roommate — your body goes through a lot of changes.
«We're now starting to think about metastatic breast cancer as a chronic disease,» says Dr. Sardesai.
He is also my best friend as I am now fighting metastatic breast cancer and he stays by my side and is keeping me happy throughout the harrowing treatments.
Clinical trials relying on the results of these tests are now underway at CUIMC, including a new study of metastatic pancreatic cancer, a phase II trial of HER2 - positive metastatic breast cancer patients who have not benefited from trastuzumab (Herceptin) therapy, and a phase II trial for gastroenteropancreatic neuroendocrine tumors.
Here, we show that a non-adherent, stem - like, and metastatic CSC - enriched subpopulation could be isolated by exposing human metastatic breast cancer cell lines to cycles of chronic hypoxia followed by reoxygenation.
This was done years ago with Herceptin [Genentech's treatment for metastatic breast cancer].»