Sources: Clemente, J.C., et al., «The Impact of the Gut
Microbiota on Human Health: An Integrative View,» Cell 2012; 148 (6): 1258 - 1270.
Review: Influence of Commensal
Microbiota on the Enteric Nervous System and Its Role in Neurodegenerative Diseases — Endres K. — Journal of Innate Immunology
There are also a number of studies involving mice reared in germ - free environments, the results of which seem to demonstrate a direct role of intestinal
microbiota on behavior.
Impact of the gut
microbiota on inflammation, obesity, and metabolic disease.
It turns out that these same factors also affect
the microbiota on our skin and protecting it may be just as important!
We next investigated the effect of gut
microbiota on infection of the hindgut by parasites.
Also see a previous review: Influence of intestinal
microbiota on body weight gain: a narrative review of the literature — Camila S. Cardinelli et al. — Obesity Surgery
Reoccurring review (no abstract available): Letter to the Editor: Influence of Intestinal
Microbiota on Body Weight Gain: a Narrative Review of the Literature — Andre Alonso Taco - Masias and Augusto Rafael Fernandez - Aristi — Obesity Surgery
Also, using this model we are evaluating the role of
microbiota on the response to anti-PD-1 Ab treatment.
Impact of
the Microbiota on Bacterial Infections during Cancer Treatment — Jessica Galloway - Peña — Trends in Microbiology
Review: Impact of the Gut
Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism.
At Weizmann, she plans to investigate the impact of gut
microbiota on aging, and her goal is to improve human health through personalized nutrition.
Effects of Intestinal
Microbiota on Brain Development in Humanized Gnotobiotic Mice — Jing Lu — Scientific Reports
The impact of
the microbiota on bone marrow transplantation in mice, differences in phage infection efficiency in nearly identical hosts, bacterial diversity of Brazilian artisanal cheese.
Not exact matches
Using a «gnotobiotic mouse model» — where mice were «colonized with a synthetic human gut
microbiota composed of fully sequenced commensal bacteria» — Desai et al reported
on the effects of different diets with different fibre content.
It is a full - spectrum prebiotic fiber that nourishes bacteria
on both sides of the colon and inhibits the growth of undesirable
microbiota.
The human microbiome is the composite of genes of the microorganisms (
microbiota) living in and
on the human body that influence the health and development of the host (1).
A small study of 60 randomly selected 7 - year - old children, 31 delivered by cesarean and 29 delivered vaginally, assessed
microbiota composition by determining fecal
microbiota profiles using culture - independent fluorescent in situ hybridization and compared the respective effects of delivery mode
on gut
microbiota (12).
Thus, modulation of maternal gut
microbiota during pregnancy and lactation could have a direct effect
on infant health.
Our gut hosts a community of trillions of microbes, called the gut
microbiota, and we are becoming increasingly aware that this has significant effects
on many aspects of our health.
Effect of predatory bacteria
on the gut bacterial
microbiota in rats.
Little is known, however,
on how gut and skin
microbiota composition is controlled.
In a recent study published in the journal Nature Communications
on 17 September, John Baines, Saleh Ibrahim and their colleagues of the Inflammation Research Excellence Cluster show that composition of skin
microbiota is controlled by the host genome and that skin bacteria may have a greater influence
on inflammatory diseases than previously thought.
The researchers found that changes in the amount of protein and carbohydrates in the diet had a similar effect
on the
microbiota of dogs and humans, independent of the dog's breed or sex.
Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data from dogs to study the impact of diet
on gut
microbiota in humans, and humans could be a good model to study the nutrition of dogs.
The Wyss team believes the ability of the human gut -
on - a-chip to culture the microbiome with human gut cells also holds promise for the field of precision medicine, where a patient's own cells and gut
microbiota could one day be cultured inside a gut -
on - a-chip for testing different therapies and identifying an individualized treatment strategy.
Researchers working
on the Ribeirão Preto campus of the University of São Paulo (USP) in Brazil have discovered that a bacterium found in the
microbiota associated with leafcutter ant species Atta sexdens rubropilosa produces the so - called «trail pheromones,» i.e, the aromatic chemical compounds used by the ants to lay a trail to their nest.
«Healthy gut bacterial communities are known to benefit immune regulation, metabolism and potentially even the nervous system, so if cholera or other diarrheal diseases permanently impact the
microbiota, there could be long - term effects
on human health,» explains Regina LaRocque, MD, MPH, of the Massachusetts General Hospital (MGH) Division of Infectious Diseases, co-senior author of the paper.
The review centers
on a first of its kind study in which researchers characterized the gut bacterial
microbiota (bacteriome) and fungal community (mycobiome) in a number of families that had members with CD and healthy relatives.
The study, led by Professor Margaret Morris, the Head of Pharmacology at UNSW, examined the impact of yo - yo dieting
on the gut
microbiota of rats.
The article, «Effects of weight loss while feeding a moderate - protein, high - fiber diet
on body composition, voluntary physical activity, and fecal
microbiota of overweight cats,» is published in the American Journal of Veterinary Research.
Despite the fact that this particular study was conducted
on mice, it is clear that maintaining a healthy gut
microbiota is key to a healthy lifestyle.
The research also sheds new light
on why fecal
microbiota transplantation may work so well, despite the uniqueness of each individual's microbiome.
However, it seems likely that changes in our gut
microbiota and their metabolic products are important in explaining the influence of diet
on many aspects of health, says Harry Flint at the University of Aberdeen, UK.
«These findings suggest that bi-directional communication is occurring, with stress impacting the
microbiota, and
on the other hand, with some specific bacteria in turn impacting the response to stress,» said Dr. Benoit Chassaing, assistant professor in the Neuroscience Institute at Georgia State.
This is an exciting possibility that builds
on evidence that gut
microbiota can regulate social behavior and is being investigated by Huhman and Chassaing.
The article focuses mainly
on patients with cancer, who often undergo treatments that can cause profound alterations in the gut
microbiota and potentially contribute to the development of complications.
They conclude: «We provide here tangible evidence of the impact of a healthy diet and a Mediterranean dietary pattern
on gut
microbiota and
on the beneficial regulation of microbial metabolism towards health maintenance in the host.»
Development of a healthy gut
microbiota can have a lifelong effect
on health, and early intervention in the establishment of that
microbiota could have lifelong positive effects: The early establishment of bifidobacteria has been shown to be associated with improved immune response to vaccines, development of the infants» immature immune system, and protection against pathogens.
Reetta Satokari's group has an interesting ongoing project where they look at the effects of faecal
microbiota transplant
on antibiotic resistance genes detected in the patient's
microbiota.
«There are all these smoking guns to indicate that the
microbiota may be involved [in asthma], but there were no experiments to prove it,» says microbiologist Brett Finlay of the University of British Columbia (UBC), Vancouver, in Canada, a senior author
on the paper.
Identifying
microbiota - derived metabolites and understanding their effects
on specific host functions could open up new avenues of basic and clinical research to develop safe, targeted therapies involving molecules that, by definition, constitute the natural chemical makeup of the host.
We would hope that our review leads to research
on the link between the gut
microbiota and ASD, and eventually a cheap and effective treatment.»
In vivo tests
on mice then confirmed the presence of more than half of the predicted metabolites, including two novel metabolites, which play a role in the pathways that regulate
microbiota metabolism as well as host immune function.
The research team focused
on aromatic amino acids (AAAs) because their metabolites are involved in many of the more than 2,400 distinct reactions expressed in the
microbiota as a whole.
By injecting daily a low dose of a large spectrum antibiotic they were able to reverse the effects of high fat diet
on the
microbiota composition.
«Up until now, it was impossible to study the impact of probiotics
on gut
microbiota at a bacterial species level; from now
on we will have a much more detailed view of the dynamics of this ecosystem» says Dusko Ehrlich.
Babies are born without bacteria in the gut, and so it is interesting to identify the influence dietary factors have
on gut
microbiota development in children's first three years of life,» research manager at the National Food Institute Tine Rask Licht says.
Ongoing research in the Morris lab is investigating the impact of lifestyle measures such as exercise
on gut
microbiota and behaviour, and testing novel interventions.
However, to date there is no information
on the long - term effects of antibiotics
on children's
microbiota.