Microsatellite mutation models insights from a comparison of humans and chimpanzees Sainudiin, R., R. T. Durrett, C. F. Aquadro, and R. Nielsen.
Not exact matches
While Wells screened the Central Asian Y chromosomes for single - nucleotide
mutations such as M45, Zerjal searched for a different DNA variable called a
microsatellite.
Application in detecting
mutations and
microsatellite instability (MSI) using circulating DNA from clinical cancer samples will be presented.
Both cancer types demonstrate a high frequency of
microsatellite instability, where the repair mechanism for DNA is broken, and
mutations in POLE, a gene responsible for producing a protein involved in DNA replication and repair.
The researchers mapped genetic variation in the Penicillium across Thailand by looking at «
microsatellites,» small regions of DNA that are prone to
mutation.
The
mutation identified is a
microsatellite repeat within intron 7 of the gene.
Methodology / principal findings: Population genetic structure was assessed through
microsatellite analysis, and the impact of insecticide pressure by genotyping two target - site
mutations, Vgsc - 1014F of the voltage-gated sodium channel target of pyrethroid and DDT insecticides, and Ace1 - 119S of the acetylcholinesterase gene, target of carbamate and organophosphate insecticides.
These
microsatellites or
mutations act as «markers» that researchers implement in order to identify each breed.