Sentences with phrase «microtubule at»

Not exact matches

In case of any doubt, Wired also learned that, while at Harvard graduate school (right before dropping out to join Google) Damore wrote and performed in a skit about «Microtubule Jerking» and the women who helped with it.

This interrupts the transport of cellular materials along axonal microtubules, causing these materials to accumulate at several points along the axon where they may give rise to varicosities.

However, when they then «fixed» a specific hinge region of the dynein molecule that is known to connect dynein to its microtubule, they discovered that the dynein to spontaneously moved in its characteristic direction when force was applied at the ATP binding site, matching the way it moves in nature.

Fostamatinib's effect on microtubules seems to increase the stabilizing effect of paclitaxel, even in resistant cells, which in turn may prevent cancer cells from proliferating, says Yu Yu, Ph.D., a postdoctoral fellow at the Johns Hopkins University School of Medicine and co-author of the study.

These tensional forces then drive cyclic bending of the microtubules, which causes rhythmic flexing of the sperm tail at the whole cell level.

At the end, motor - dependent shrinkage thus competes with microtubule growth.

In this latest study, she and her group used cryo - EM, in which protein samples are flash - frozen at liquid nitrogen temperatures to preserve their natural structure, to determine microtubule structures in different nucleotide states with and without EB3.

«Sensitive teeth are caused by the movement of fluid in tiny holes in dentine called microtubules, which puts pressure on the nerve below,» says Nigel Hughes, one of the researchers at Unilever.

This particular active material, originally developed at Brandeis University, borrows elements of cellular machinery, with bundles of rod - like microtubules forming the filaments, kinesin motor proteins acting as the engines, and ATP as the fuel.

Bandyopadhyay's NIMS group found that microtubules have remarkable electronic conductive properties when excited at certain specific resonant frequencies, e.g. in the low megahertz, precisely the range of TUS.

«I was always quite skeptical of Stuart's claims about microtubules,» says Anthony Hudetz, a neuroscientist in the anesthesiology department at the University of Michigan.

His team found that, from its vantage point at the minus - end of an existing microtubule, Kinesin - 14 attaches to a second protein that is bound to the plus end of a growing microtubule.

Now, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have observed how microtubules and motor proteins assemble into macroscopic networks.

The technique offered precise localization of dynamic microtubule plus - end hub protein EB1 dimers, and their distinct distributions at the leading edge and cell body of migrating cells, the researchers report.

The research group working at IBMC focused on the exact moment of cell division, when cells assemble a new microtubule network, which is then arranged as a very well - known structure: the mitotic spindle.

Every cell in our bodies contains a railway network, a system of tiny tracks called microtubules that run between important destinations inside the cell and allow cargo to be carried from one place to another, reports Professor Rob Cross, Professor of Mechanochemical Cell Biology at Warwick Medical School.

Professor Rob Cross, Professor of Mechanochemical Cell Biology at Warwick Medical School, said: «Every cell in our bodies contains a railway network, a system of tiny tracks called microtubules that run between important destinations inside the cell and allow cargo to be carried from one place to another.

The team at Leeds, working within the world - leading Astbury Centre for Structural Molecular Biology, combined purified microtubules with purified dynein motors and added the chemical fuel ATP (adenosine triphosphate) to power the motor.

The researchers looked at seeds that have either all GTP or all GDP subunits and found each strongly influences all phases of microtubule growth.

Originally identified as a protein essential for mitosis in fungi, kinesin - 5 was first purified about 20 years ago by Scholey's lab who found that it is unusual because it has motor units at both ends, allowing it to link two microtubules and walk them past each other.

He said most theoretical investigations of microtubules have only looked at their stationary states, or assumed the breakdown of a microtubule happened all at once.

Dr Stan Burgess, at the University of Leeds» School of Molecular and Cellular Biology, who led the research team, said: «Dynein has two identical motors tied together and it moves along a molecular track called a microtubule.

But the laws of quantum mechanics allow for electrons to be both «left» and «right» at the same time, and thus for the microtubules to be both elongated and squashed at once.

Motor proteins carry cargoes along microtubules in cells as seen in this image from an earlier study at Rice.

A group of plant biologists at the Institute of Transformative Bio-Molecules (ITbM) of Nagoya University, the University of Tokyo, the Gregor Mendel Institute, and the University of Kentucky, has reported in the journal Proceedings of the National Academy of Sciences, on their discovery on how the plant's egg cells initially lose their skeletal pattern upon fertilization and are reorganized by two major cytoskeleton components in the cell, microtubules (MTs) and actin filaments (F - actin).

Johanna Roostalu is a Sir Henry Wellcome Postdoctoral Fellow at the Cancer Research UK London Research Institute where she is working on a project to elucidate the molecular mechanism of spindle assembly and microtubule self - organization using a combination protein biochemistry, fluorescence microscopy, microfluidics and mathematical modeling.

WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics.

Microtubule - targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton.

The cell end marker TeaA and the microtubule polymerase AlpA contribute to microtubule guidance at the hyphal tip cortex of Aspergillus nidulans for polarity maintenance.

The microtubules in amo1Delta cells have longer dwelling times at the cell tips, and grow in an uncoordinated fashion.

He completed his master's in biotechnology at the University of Pennsylvania, where he worked in Michael Lampson's lab studying microtubule — kinetochore dynamics during mitosis.

Research in my lab is directed at understanding the role of the microtubule network in cell organization and function.

Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criteria

He received the Award of Excellence of the University of Heidelberg as well as the Otto - Haxel - Prize for his diploma work at the European Molecular Biology Laboratory (EMBL) on the «Analysis of microtubule dynamic instability with light sheet - based microscopy».

As a graduate student at the European Molecular Biology Lab in Heidelberg he used cryo - EM to study kinesin motors, capturing snapshots that show how kinesin «walks» along a microtubule.

As mitosis progresses, the microtubules align the chromosomes along the mid-line of the cell, then shorten and pull the chromosome pairs at their centromeres to opposite sides of the cell.

Voyager emits specific low level radio frequency energy that blocks cancer cells from dividing by blocking the dis - assembly of microtubule, leading to aberration, multi-nucleation and interruption of mitotic spindle activity during cell division, at metaphase