Sentences with phrase «models animal lab»
Diet - Induced Metabolic Syndrome in Rodent Models Animal Lab News - March 2007 Angela M. Gajda, MS, Michael A. Pellizzon, Ph.D., Matthew R. Ricci, Ph.D. and Edward A. Ulman, Ph.D..
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By studying human cancer cells and animal models of cancer in the lab, our researchers have shown that loss of PTEN leads to high levels of PI (3,4) P2, which could result in hyperactivation of AKT.
In the lab, researchers will try to re-create the Thai results in monkeys to validate a new animal model using multiple low doses.
Strategies that boost the cell's quality control programs, rather than disarm specific pathologic proteins, have looked promising in lab animals that serve as models for human neurodegenerative disorders including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.
The study — which looked at the action of Substance P within nerve cells in the lab and in animal models — focused on acute pain, but Professor Gamper aims to look at its role within chronic pain as well.
To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.
«The result was an extensive inhibition of tumor growth and prevention of metastasis to the lung in HER2 - positive animal models of breast cancer,» notes Navasona Krishnan, Ph.D., a postdoctoral investigator in the Tonks lab who performed many of the experiments and is lead author on the paper reporting the results.
The TNP lab previously demonstrated in animal models that tau is a critical part of the «garbage disposal system,» in cells allowing them to clear accumulated toxic proteins.
Stories on how making lab animals happy may make them better experimental models, and the chemistry that's happening in the air and on surfaces in our homes
Daniel Villarreal, a graduate student in the Weiner lab, and colleagues report in Cancer Research this week that the protein IL - 33 boosts the immune system of a human papilloma virus animal model of cancer.
His lab initially tried making the virus more transmissible in ferrets — virologists» preferred animal model — by mutating key genes.
The researchers grew the modified cells in the lab to increase their numbers and then injected them into an animal model where they again killed human myeloma cells.
Because M. lepromatosis can not be grown in the lab and animal models for this version of leprosy do not exist yet, the scientists used an infected skin sample from a patient in Mexico to obtain the bacterium's genetic material.
TOKYO — One of science's favorite lab animals, the mouse, is about to become an even more useful model system.
If the marriage of stem cells and CRISPR follows a similar path, it might not be long before pigs have enough Homo sapiens in them not only to grow human hearts, lungs, livers, and kidneys for transplant but also to model human diseases more closely than current lab animals do and to test experimental drugs.
Researchers at McLean's Behavioral Genetics Lab are using animal models to study the effects of nicotine on vulnerability to post-traumatic stress disorder (PTSD) in a study funded by the Department of Defense (DoD).
In addition, previous studies done in Wang's lab suggest that BCX, through a different molecular mechanism, can slow the nicotine - promoted growth of lung tumors and decrease cigarette smoke - induced lung inflammation in animal models.
The lab recently developed an animal model of BED in which rats are given irregular, limited access to chocolate along with normal chow.
Kostic's lab will develop an animal model that will help to unravel how gut bacteria interact with the immune system.
In 2002, the lab proved that transplanting embryonic stem cells in animal models of Parkinson's disease yielded functional new dopamine neurons that restored motor function.
There's more to these findings than just lofty philosophical quandaries, though: If ravens really do possess a level of social cognition comparable to humans and other large primates, the birds might serve as better animal models to study this kind of behavior in the lab — which could help scientists understand why some humans are better at this kind of inference than others, and why some individuals can't manage it at all.
To take a finding in basic research, such as identifying a mutant protein that drives a particular cancer, and develop a drug that inactivates the protein and performs well in cells in the lab and in animal models can take years, if not decades.
And findings from clinical trials in humans can, conversely, generate hypotheses that need to be further investigated in cells or animal models in the lab.
Scientists from the LoGrasso lab have been able to show in animal models that inhibiting a specific enzyme protects heart cells and surrounding tissue against serious damage from heart attacks.
The lab has examined MRI cell tracking in animal models of dysmyelination, multiple sclerosis, brain tumors, spinal cord, stroke, and diabetes.
His lab develops isogenic human pluripotent stem cells and transgenic animals to model disease, with the goal of delineating novel approaches to influence outcomes for Huntington disease (HD) and Fragile X Syndrome (FXS), the most common genetic causes of dementia and intellectual disability, respectively.
Diet - Induced Metabolic Syndrome in Rodent Models - An article from the March 2007 issue of Animal Lab News on how diets made from purified ingredients influence the phenotypes of the MS in commonly used rodent models, authored by our scienModels - An article from the March 2007 issue of Animal Lab News on how diets made from purified ingredients influence the phenotypes of the MS in commonly used rodent models, authored by our scienmodels, authored by our scientists.
Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.
The mini brains are derived from human stem cells thus, may be used instead of animal models to test new drugs, revolutionizing the way lab experiments work.
Dr. Ressler's lab focuses on translational research bridging molecular neurobiology in animal models with human genetic research on emotion, particularly fear and anxiety disorders.
This unique international event will provide the attendees with an innovative program focused on the best practices in the use of the mouse model for biomedical and basic research; this program also addresses the item of continuing professional education consistent with the new European directive requirement for lab animal protection in experiments.
The lab is working to harness this mechanism to improve the clinical outcome in animal models of the many neurodegenerative disorders that have an inflammatory component, including ALS, Alzheimer's and Parkinson's diseases.
Our lab makes use of animal models of either physiological or pathological remodeling to study the underlying molecular pathways of these remodeling responses.
Stemming from this initial research, my lab is now investigating how changes in the microbiome contribute to the development of IBD in an animal model of the syndrome.
Thus, the analytical tools developed by the Schroeder lab to identify structures and functions of biogenic small molecules will be transferable to other animal models.
Using the fruit fly Drosophila, a standard lab model for studying animal biology, the researchers discovered a cascade of molecular signals that program gene activity to drive the fly from one stage of maturation to the next, like a baby turning into an adult.
She works in a WSU lab that focuses on evaluating hormonal regulation in the oviduct and uterus during fertilization, pre-implantation embryo development and embryo transport using genetically engineered animal models.
After the lab work concluded, each student was required, outside of school, to conduct their own research and create a 3D Cell Model Project that displayed the types of organelles (animal vs. plant cell) that were covered in class.
Transgenic Fly Lab (LS.1 j; LS.13 f; LS.14 a; BIO.5 j) This virtual lab allows students to create transgenic organisms using a animal model, a fruit fly, to study circadian rhythLab (LS.1 j; LS.13 f; LS.14 a; BIO.5 j) This virtual lab allows students to create transgenic organisms using a animal model, a fruit fly, to study circadian rhythlab allows students to create transgenic organisms using a animal model, a fruit fly, to study circadian rhythms.
Dr. Gonzalez» research has aimed to develop and utilize large animal models to translate lab bench findings into clinically relevant therapeutic interventions that benefit both human and veterinary patients.
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Tags for this Online Resume: Laboratory Animals, pharmacology, lab animal science, PK / PD, in vivo research, Toxicology, necropsy, diabetes, Anti-Oxidants, Inflammation, Obesity, Cancer, Animal Models, Blood Pressure, Animal Dosing, Blood Collection and Procanimal science, PK / PD, in vivo research, Toxicology, necropsy, diabetes, Anti-Oxidants, Inflammation, Obesity, Cancer, Animal Models, Blood Pressure, Animal Dosing, Blood Collection and ProcAnimal Models, Blood Pressure, Animal Dosing, Blood Collection and ProcAnimal Dosing, Blood Collection and Processing