Sentences with phrase «molecular imaging study»

In the further elaboration, 1,4,7,10 - tetraazacyclododecane -1,4,7,10-tetraacetic acid (DOTA) was introduced as a chelator for molecular imaging studies.

Not exact matches

Earlier, for his Ph.D., he used his physics training to study biological interactions at the molecular resolution — but for his postdoc he changed approaches dramatically, turning to cell biology and applying his skills to the development of high - resolution functional imaging of DNA transcription in living cells.

This study was performed in the lab of Baozhong Shen, the TOF - PET / CT / MR Center of The Fourth Hospital of Harbin Medical University and the Molecular Imaging Research Center (MIRC) of Harbin Medical University.

There are four main areas where molecular imaging can have a major impact, according to the study's lead author David A. Mankoff, MD, PhD, the Gerd Muehllehner Professor of Radiology and director of the PET Center at the Perelman School of Medicine at the University of Pennsylvania.

A novel molecular imaging technique could be the key to understanding how best to treat these and other devastating diseases, according to a recent study presented at the 2015 Annual Meeting of the Society of Nuclear Medicine and Molecular Imagingmolecular imaging technique could be the key to understanding how best to treat these and other devastating diseases, according to a recent study presented at the 2015 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (imaging technique could be the key to understanding how best to treat these and other devastating diseases, according to a recent study presented at the 2015 Annual Meeting of the Society of Nuclear Medicine and Molecular ImagingMolecular Imaging (Imaging (SNMMI).

Hwang said the study would provide data about the best candidates for active surveillance, and create a repository of imaging and cell samples to advance knowledge into the molecular biology of DCIS and what fuels or deters its growth.

The project is called I - SPY 2, which, just barely, stands for «Investigation of Serial studies to Predict Your therapeutic response with imaging and molecular analysis 2.»

«Our findings demonstrate the feasibility of classifying cancerous and normal breast tissues using DESI mass spectrometry imaging,» said Nathalie Agar, PhD, director of the Surgical Molecular Imaging Laboratory, BWH Departments of Neurosurgery and Radiology, senior study imaging,» said Nathalie Agar, PhD, director of the Surgical Molecular Imaging Laboratory, BWH Departments of Neurosurgery and Radiology, senior study Imaging Laboratory, BWH Departments of Neurosurgery and Radiology, senior study author.

For this clinical pilot study, researchers imaged subjects undergoing routine molecular imaging procedures such as bone scans or imaging of the thyroid, eye or lymphatic system.

For the first time, scientists have used Positron Emission Tomography (PET) imaging to study brain inflammation following Zika virus infection in mice, according to a study recently published online in the journal Molecular Imaging and Bimaging to study brain inflammation following Zika virus infection in mice, according to a study recently published online in the journal Molecular Imaging and BImaging and Biology.

The study, published online in the Aug. 21, 2015, issue of Nature Communications, was led by Zheng - Rong Lu, Ph.D., CWRU M. Frank Rudy and Margaret Domiter Rudy Professor of biomedical engineering and an expert in molecular imaging for cancer and other diseases.

The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more than 9,000 human psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for psychiatric disease by interfering with the way the brain regulates connections between neurons.

«This multi-agent detection capability has the potential to transform molecular imaging, as it provides a critical translational pathway for studies in patients,» said Flask.

«Our finding of a link between bipolar disorder and the striatum at the molecular level complements studies that implicate the same brain region in bipolar disorder at the anatomical level, including functional imaging studies that show altered activity in the striatum of bipolar subjects during tasks that involve balancing reward and risk,» said TRSI Research Associate Rodrigo Pacifico, who was first author of the new study.

Paulsen's study investigated whether the addition of molecular imaging (NIRST) at the time of MRI would improve the diagnostic accuracy of breast MRI alone by contributing functional information about regions of suspicion in the breast identified by the MRI and helping to categorize the regions as malignant or benign.

It also provides a unique imaging platform to rigorously study molecular therapies.»

C.elegans has been used for decades as a model animal to study the genetic and molecular underpinnings of neurological disorders through a number of techniques including bio imaging, electrophysiology and behavior.

The study mostly makes use of cultured cortical neurons from rats, exploiting a wide array of molecular and imaging techniques to probe the mitochondrial function and well - being of neurons manipulated to model Wolfram syndrome.

«Molecular imaging of neuroendocrine tumors optimizes radiotherapy dose: Study shows the use of PET and SPECT tailors radionuclide treatment for neuroendocrine cancer patients and reduces the risk of toxicity.»

The project, which brings together physical oceanographers, marine biologists, imaging specialists, molecular biologists, bioinformaticists and modelers, uses what it calls a «holistic» and «study it all» approach, analyzing many species at once using a variety of methods, many of them automated.

Because metastasis is a complex process that has been difficult to study, Chicago's Ludwig Center will bring together researchers from various areas of expertise, including molecular biology, cell biology, genetics, bioinformatics, chemistry, imaging and medicine.

At the Museum of the Rockies we house one of the largest dinosaur collections in the country, and maintain two laboratories, one for the study of cellular and molecular paleontology, and the other for 3 - D imaging utilizing data from CT and 3 - D scanners.

«Metastatic brain tumors — often from lung, breast or skin cancers — are the most commonly observed tumors within the brain and account for about 30 percent of advanced breast cancer metastases,» says Khalid Shah, MS, PhD, director of the Molecular Neurotherapy and Imaging Laboratory in the MGH Departments of Radiology and Neurology, who led the study.

Using a combination of molecular biology, biochemical and novel multi-dimensional digital imaging approaches we study in real - time complex multi dimensional signal integration during the interaction of T cells with live antigen - presenting cells.

This multimodal study shows significant correlation between increased tau and decreased metabolic activity in the brain — a clear sign of neurodegeneration — reveal researchers at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).

A self - described «recovering molecular biophysicist,» Ellisman gave a polished presentation about the latest tools for studying the brain at the Frontiers in Chemical Imaging Seminar Series July 26 at Pacific Northwest National Laboratory.

«Deficient neuron - microglia signaling results in impaired functional brain connectivity and social behavior» Y. Zhan, R.C. Paolicelli, F. Sforazzini, L. Weinhard, G. Bolasco, F. Pagani, A. L. Vyssotski, A. Bifone, A. Gozzi, D. Ragozzino, C.T. Gross Nature Neuroscience 17 (3), 400-4006 (2014) «USPIO - loaded Red Blood Cells as a biomimetic MR contrast agent: a relaxometric study» A. Boni, D. Ceratti, A. Antonelli, C. Sfara, M. Magnani, E. Manuali, S. Salamida, A. Gozzi, and A. Bifone Contrast Media and Molecular Imaging 9, 229 - 236 (2014) «Distributed BOLD and CBV - weighted resting - state networks in the mouse brain» F. Sforazzini, A.J. Schwarz, A. Galbusera, A. Bifone, and A. Gozzi NeuroImage 87, 403 - 415 (2014) «Antimicrobial peptides design by evolutionary multiobject optimization» G. Maccari, M. Di Luca, R. Nifosì, F. Caldarelli, G. Signore, C. Boccardi, and A. Bifone PloS Computational Biology 9 (9): e1003212 (2013) «Differential effect of orexin - 1 and crf - 1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor yohimbine» A. Gozzi, S: Lepore, E: Merlo Pich, and A. Bifone Neuropsychopharmacology 38 (11): 2120 - 2130 (2013) «Water dispersal and functionalization of hydrophobic iron oxide nanoparticles with lipid - modified poly (amidoamine) dendrimers» A. Boni, L. Albertazzi, C. Innocenti, M. Gemmi, and A. Bifone.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

Findings from this research study were published in the January 2018 issue of IOVS (Investigative Ophthalmology & Visual Science), «Optic Nerve Regeneration After Crush Remodels the Injury Site: Molecular Insights From Imaging Mass Spectrometry.»

To pursue these studies, the Noma laboratory employs genomic technologies and single locus / live - cell imaging technology along with molecular and chromatin biology and epigenetics.

Additional confocal applications include microirradiation to study DNA - damage repair, 3D reconstructions and time - lapse imaging of dynamic cell and molecular processes.

We study these questions using molecular, cellular and transgenic approaches as well as real time in vitro and in vivo imaging.

In the newest scientific studies, researchers are using genomic expression and brain imaging to understand how yoga affects practitioners on a cellular and molecular level.

Project Baseline will be a four - year study of 10,000 participants, collecting such data as «clinical, imaging, self - reported, physical, environmental, and molecular and genetic measurements,» along with blood, tears, and saliva.