Molecular studies at PsychoGenics and other organizations have demonstrated that the excision of the neomycin resistance cassette results in a modest but significant increase in mutant HTT mRNA levels, and a trend towards an increase in soluble mHTT protein and extranuclear inclusions.
Not exact matches
«This technology will allow us to paint a whole chromosome and look
at it live and really follow it... as it goes through developmental transitions, for example in an embryo,»
study co-author Rebecca Heald, a
molecular and cell biologist
at UC Berkeley, said in a statement.
So I'm
at MIT as an undergrad, and I'm
studying molecular biology as premed.
And he ran down SoHe who was only 22 and a Toronto university
studying molecular biology and he aimed the steering wheel
at Betty and accelerated — Betty whose mother had long ago named her Mary Elizabeth — and who was revelling in one of the first warm April days in her 95th — and last — spring on this spinning orb.
«Our new findings show that in the absence of embryonic movement the cells that should form articular cartilage receive incorrect
molecular signals, where one type of signal is lost while another inappropriate signal is activated in its place,» Paula Murphy, a professor of zoology
at Trinity College Dublin who co-led the
study, says.
I am
studying molecular biology
at BYU.
Boivin had
studied cellular,
molecular, and microbial biology for her Bachelor of Science degree
at the University of Calgary in her native Canada, but, she says, «I always had an interest in archaeology.»
By looking
at reproduction as both a source of cooperation and conflict between the sexes, the researchers are finding clues from this
study on a behavioral and
molecular level that can be an important link for solving certain unexplained causes of human infertility.
Mangahas
studied plant biology and botany during his undergraduate years
at the University of Washington, Seattle, as well as
molecular biology.
«This is a big step in determining the identity of key components of the
molecular machinery that converts sound waves into electrical signals in the inner ear,» said the
study's co-senior author, Gregory Frolenkov, of the Department of Physiology
at the University of Kentucky.
Furthermore, he says, his years
studying yeast
at the
molecular level — supplemented by formal training and further research in the enology program
at the University of California (UC), Davis — has sharpened his winemaking intuition.
«It requires student initiative to connect with the right role model / adviser,» says Todd Evans, a professor of developmental and
molecular biology and Assistant Dean for Graduate
Studies and Director of the Graduate Program
at the Albert Einstein College of Medicine of Yeshiva University in Bronx, New York.
The fields within biology are further divided based on the scale
at which organisms are
studied and the methods used to
study them: biochemistry examines the fundamental chemistry of life;
molecular biology
studies the complex interactions of systems of biological molecules; cellular biology examines the basic building block of all life, the cell; physiology examines the physical and chemical functions of the tissues and organ systems of an organism; and ecology examines how various organisms interrelate.
It turns out that taste buds are doing more than we think,» says senior author of the University of Michigan - led
study Scott Pletcher, Ph.D., associate professor in the Department of
Molecular and Integrative Physiology and research associate professor
at the Institute of Gerontology.
«We have confirmed what earlier
studies indicated, and gained new knowledge about
molecular characteristics of these neural stem cells,» says Milos Pekny, professor
at the Institute of Neuroscience and Physiology.
«Nonetheless, the proof of concept
studies we have obtained thus far are extremely encouraging, and we are confident that with proper support and efforts we could translate our findings into experimental therapeutics for a variety of solid tumors that are driven by EphA2 overexpression, including breast, lung, prostate, pancreatic, and ovarian cancers,» said Pellecchia, who serves as the founding director of the Center for
Molecular and Translational Medicine
at UCR.
In doing so, the team has provided a
molecular dynamics tool that allows for the
study of various heat transfer problems
at the nanoscale, including understanding and utilizing passive liquid flows.
Zhou, who is the director of virology and
molecular biology for Microbac Laboratories, headquartered in Pittsburgh, Penn., said the
study did not yet look
at the survivability of Zika on hard non-porous surfaces beyond eight hours.
Before now, researchers were unable to
study it
at nanoscales in
molecular simulation.
«Our aim was to explore the effect of a more acidic ocean on every gene in the coral genome,» says
study lead author Dr Aurelie Moya, a
molecular ecologist with the ARC Centre of Excellence for Coral Reef
Studies at James Cook University.
In collaboration with Anna Pyle, Howard Hughes Medical Institute investigator and professor in the Department of
Molecular, Cellular and Developmental Biology
at Yale, Patrizio and his team
studied samples from 20 cumulus cells in 15 patients younger than age 35 and in those age 40 and older.
There, I got to
study tuberculosis not only on the level of macroscopic bone changes as before, but also look
at the
molecular level and search for the pathogen's DNA.
WASHINGTON, D.C. — Congress has launched an investigation into controversial human embryo
studies conducted by Mark Hughes, a
molecular geneticist who once worked
at the National Institutes of Health (NIH).
The new
study's findings build upon prior research by Dr. Roger Lo, a professor of medicine (dermatology) and
molecular and medical pharmacology
at the David Geffen School of Medicine
at UCLA.
I first became aware of bioinformatics while in graduate school
at the University of Colorado, Boulder,
studying molecular, cellular, and developmental biology.
«These findings stimulate new avenues for cell therapy approaches for regenerative medicine,» said Douglas Millay, PhD,
study senior investigator and a scientist in the Division of
Molecular Cardiovascular Biology
at Cincinnati Children's.
A new
study sheds light on unique property of 2 - D materials — ability to shield chemical interactions
at the
molecular level.
The data simply looked spectacular,» says Thijs Ettema
at the Department of Cell and
Molecular Biology, Uppsala University, who lead the scientific team that carried out the
study.
Wehrenberg said the results of this
study are directly applicable to Lawrence Livermore's efforts to model both plasticity and tantalum
at the
molecular level.
In addition to Jorgensen, who holds a doctorate in
molecular biology, founding members include science writer Daniel Grushkin; Sung Won Lim, a physics undergraduate; and Russell Durrett, who
studies biotechnology and entrepreneurship
at the Polytechnic Institute of New York University.
Gabor Csanyi, a professor of
molecular modeling in the Department of Engineering
at the University of Cambridge, contributed to this
study.
To link,
at a
molecular level, a gene variant with biochemical changes and clinical symptoms related to a heritable psychiatric disorder, as in this present
study, is therefore something of a breakthrough.
In the future,
studies are aimed
at using novel
molecular approaches to selectively delete AMPK in specific brain regions associated with nicotine dependence to better understand the functional role of this protein in addiction.
«We found that a particular vaginal bacterium, Gardnerella vaginalis, did not cause infection during exposure to the urinary tract, but it damaged the cells on the surface of the bladder and caused E. coli from a previous UTI to start multiplying, leading to another bout of disease,» said the
study's senior author, Amanda Lewis, PhD, an assistant professor of
molecular microbiology and of obstetrics and gynecology
at Washington University.
Research for the
study was conducted by first co-authors Dr. Ranit Kedmi and Nuphar Veiga and colleagues
at Prof. Peer's TAU Laboratory, in collaboration with Prof. Itai Benhar of TAU's School of
Molecular Cell Biology and Biotechnology, Dr. Michael Harlev of TAU's Veterinary Service Center, Dr. Mark Belkhe of Integrated DNA Technologies (IDT) and Prof. Judy Lieberman of Boston Chidren's Hospital and Harvard Medical School.
«Finding these similarities and
studying the aspects of mouse biology that may reflect human biology, allows us to approach the
study of human illnesses in a better way,» affirms Bing Ren, one of the principal authors from the ENCODE Consortium and a lecturer in
molecular and cellular medicine
at the University of California — San Diego.
«It is very clear that synthetic binding technologies are now mature,» said
study co-author Shohei Koide, PhD, professor of biochemistry and
molecular biophysics
at the University of Chicago and a world - leader in monobody research and design.
«The
study results elucidate the
molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences
at Mount Sinai and senior author of the
study.
«Understanding how the enzyme actually works requires the knowledge of its three dimensional
molecular structure
at the atomic level,» said Dr. Mueller, principal investigator for the
study that used cryo - electron microscopy (cryo - EM) to reveal the enzyme
at near atomic resolution.
They contacted Anutosh Chakraborty, a
molecular biologist who was
studying such mice down the hall
at Scripps
at the time.
Immune system defenses against dangerous bacteria in the gut can be breached by turning off a single
molecular switch that governs production of the protective mucus lining our intestinal walls, according to a
study led by researchers
at Yale, the University of British Columbia, and the Weizmann Institute of Science.
In the
study, the research team identified three distinctive characteristic regimes with regard to the degree of slip
at the interface and revealed the underlying
molecular mechanisms for each regime: (i) the z - to - x chain rotation mechanism in the vorticity plane in the weak flow regime, which effectively diminishes the wall friction against chain movement along the flow direction, (ii) the repetitive chain detachment - attachment (out - of - plane wagging) and disentanglement mechanism in the intermediate regime, and (iii) irregular (chaotic) chain rotation and tumbling mechanisms in the strong flow regime.
Published in
Molecular Neurobiology, the
study led by Dr Elodie Siney under the supervision of Dr Sandrine Willaime - Morawek, Lecturer in Stem Cells and Brain Repair
at the University, analysed how enzymes called ADAMs affect the movement and function of the human tumor cells.
Reasoning that boosting the clock may be beneficial, Zheng «Jake» Chen, Ph.D., the
study's senior author and assistant professor of biochemistry and
molecular biology
at John P. and Kathrine G. McGovern Medical School
at UTHealth, launched a search for a clock amplitude - enhancing small molecule.
Liu, who was an investigator
at the Children's National Medical Center in Washington DC during the research, decided to
study tissues removed from eight patients with either focal cortical dysplasia or tuberous sclerosis complex to see if she and her co-authors could discern what might be going awry
at the
molecular level.
A new
study published in Nature Communications by researchers from the MRC Centre for Developmental Neurobiology (MRC CDN)
at IoPPN, carried out in collaboration with the Tian lab
at the Rutgers New Jersey Medical School (USA), unravels how this synchrony is achieved
at the
molecular level.
After finishing her Ph.D.
studies in
molecular biology
at the Hellenic Pasteur Institute in Athens in 1998, Alexopoulou headed for the United States.
But a new genetic
study of a 1000 - year - old skeleton from the Bahamas shows that
at least one modern Caribbean population is related to the region's precontact indigenous people, offering direct
molecular evidence against the idea of Taino «extinction.»
The newest comer into this wild and speculative debate is Philip Bell, who
studies yeast
molecular biology
at Macquarie University in Australia.
Dmitry Royhman, currently
studying to get his PSM in cell and
molecular biology
at IIT, says, «The reason I chose to do the PSM instead of the traditional Master's degree was because the M.S. would have restricted me more toward research, and I was not sure that was the path for me.»