Sentences with phrase «molecular studies revealed»

Not exact matches

The study, led by Dr Len Stephens and Dr Phill Hawkins and published today in the journal Molecular Cell, reveals why loss of the PTEN gene has such an impact on many people with prostate cancer, as well as in some breast cancers.

In particular, the study, published Jan. 6 in the journal Molecular Psychiatry, revealed differences in the white matter of patients» brains and in the cerebellum, an area of the brain not previously linked with the disorder.

Other molecular information from patients may reveal these so - called «hidden responders,» according to a Penn Medicine study in Cell Reports this week.

«Understanding how the enzyme actually works requires the knowledge of its three dimensional molecular structure at the atomic level,» said Dr. Mueller, principal investigator for the study that used cryo - electron microscopy (cryo - EM) to reveal the enzyme at near atomic resolution.

In the study, the research team identified three distinctive characteristic regimes with regard to the degree of slip at the interface and revealed the underlying molecular mechanisms for each regime: (i) the z - to - x chain rotation mechanism in the vorticity plane in the weak flow regime, which effectively diminishes the wall friction against chain movement along the flow direction, (ii) the repetitive chain detachment - attachment (out - of - plane wagging) and disentanglement mechanism in the intermediate regime, and (iii) irregular (chaotic) chain rotation and tumbling mechanisms in the strong flow regime.

The first study used fruit flies as an in vivo test system to reveal new evidence about the function of a key influenza protein called NS1, which has evolved to target molecular pathways in the host.

This pre-clinical study from Professor Mazzone and his colleagues reveals a new molecular axis that may offer interesting therapeutic opportunities for the treatment of pancreatic cancer, breast cancer and lung cancer, among others.

A recent study published in Cell Chemical Biology has revealed new insights into a molecular pathway that leads to Staphylococcus aureus virulence.

The study, which appears in the current issue of the journal Genome Biology, is the first to reveal on a molecular level how loneliness puts people at risk for disease, says Cole.

«Studies are underway to reveal how seizures affect various types of memory and to explore the associated molecular signaling and morphological alterations,» says author Angela Carter, a predoctoral fellow in the laboratory of Dr. Anne Anderson at the Baylor College of Medicine.

A study published in Molecular Cancer Research reveals that a tumor suppressor gene p16 is turned off by a histone mutation (H3.3 K27M), which is found in up to 70 percent of childhood brain tumors called diffuse intrinsic pontine glioma (DIPG).

To try to answer that, we looked for molecular differences that could reveal aspects of motor neuron diversity — and the study started with a molecular screen to try and find genetic differences between different subtypes of motor neurons.

«Our study not only provides new molecular data that complement the work of the American team but also reveals key microanatomical facts, explains Michel Milinkovitch.

In the study, the researchers also reveal the molecular mechanism through which the protein dDsk2 binds to chromatin proteins, thus participating indirectly in the regulation of transcription.

A report published in March in the journal Trends in Genetics revealed that the lizardlike native of New Zealand has undergone the fastest rate of molecular evolution of any vertebrate animal studied thus far.

Rod Kellems, Ph.D., study co-author and chairman of the Department of Biochemistry and Molecular Biology at the UTHealth Medical School, added, «This research provides insight into how red blood cells work, revealing that SphK1 - mediated elevation of S1P contributes to sickling and promotes disease progression and highlights potential therapeutic opportunities for sickle cell disease.»

A new study by researchers at Duke University and the Max Planck Florida Institute for Neuroscience reveals unexpected molecular mechanisms by which these changes take place.

In a study appearing in the Dec. 10 online edition of Neuron, they revealed that two different mutations of the Shank3 gene produce some distinct molecular and behavioral effects in mice.

The researchers» next step is to study more cell types and reveal the mechanisms that set certain cells apart in terms of their ultra-sensitivity to single molecular forces.

The study is «a superb example of how new tools from molecular biology can reveal cryptic, unsuspected variation in even well - known vertebrates like birds,» says H. Lisle Gibbs of McMaster University in Hamilton, Ontario.

«Such a mosaic anatomical evolution may well be related to the somewhat similar molecular mosaic evolution between the three species revealed by previous genetic studies: each of the chimpanzees species share about 3 percent of genetic traits with humans that are not present in the other chimpanzee species.»

The study is the first to reveal the molecular processes that may help coral reef fishes and other marine species adjust to warmer conditions in the future.

A new study in fat cells has revealed a molecular mechanism that controls how lifestyle choices and the external environment affect gene expression.

Published in the journal Nature Structural & Molecular Biology, the study reveals new insights into translation regulation, an essential step in genome regulation.

A new study from the University of Michigan Comprehensive Cancer Center reveals molecular changes within a tumor that are preventing immunotherapy drugs from killing off the cancer.

This multimodal study shows significant correlation between increased tau and decreased metabolic activity in the brain — a clear sign of neurodegeneration — reveal researchers at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).

The study is published in the current edition of Molecular Cell and entitled DNA Repair Profiling Reveals Non-random Outcomes at Cas9 - Mediated Breaks.

The methods used to make this discovery, which involved studying the motion of gas inside molecular clouds, could, in the future, reveal stray black holes that may otherwise have remained hidden.

2) The co-author of the study revealing the molecular pathway of endoderm development, published in Current Biology, (September) was Jonathan Alexander.

The study demonstrates that evolution often is not a linear process; thanks to modern molecular methods it's complex processes are finally revealed.

«We found that a heritable genetic element based on protein folding, not encoded in DNA or RNA, allows yeast to acquire many silent changes in their genome and suddenly reveal them,» said Susan Lindquist, PhD, professor of molecular genetics and cell biology at the University of Chicago, Howard Hughes Investigator and principal author of the study.

The second area is pharmacology based on automated screening of large libraries of compounds with therapeutic potential, following modeling of molecular mechanisms associated with diseases, as revealed by the study of pluripotent stem cells from affected donors.

Now a new Weizmann Institute - led study, published in Molecular Cell, reveals a potential molecular mechanism behind tMolecular Cell, reveals a potential molecular mechanism behind tmolecular mechanism behind this link.

10/10/2007 Researchers Reveal Repressor Protein Blocks Neural Stem Cell Development A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Me... More...

In his studies, he uses an inter-disciplinary approach and combines physiological, molecular, viral and computational approaches to reveal the structure and function of retinal neuronal circuits.

These findings on gene expression in single embryonic stem cells are in concert with recent studies of early mammalian development, which reveal molecular heterogeneity and a stochasticity of gene expression in blastomeres.

For example, studies of cell signaling pathways in normal cells and cancer cells have contributed greatly to our knowledge about the disease, revealing molecular alterations that are shared among different types of cancer and pointing to possible strategies for treatment.

249/3: 45 Clinical, molecular, and metabolomic studies reveal targets for therapy and new mechanisms of pathology in Barth Syndrome.

Five hundred cancer patients are getting an in - depth look at their genomes as part of a new clinical study that is revealing some of the key molecular drivers of metastatic cancers.

They even conducted real - time molecular dynamics simulations to study how these interactions varied over time, revealing new ways to make molecules more selective toward a specific WNK enzyme.

«Future research will reveal the molecular mechanisms behind this immediate stress response and elucidate its role in the development of diseases associated with chronic sleep loss,» said Katrin Ackermann, PhD, the study's lead author.

Abstract Background: Recent molecular studies have revealed a highly complex bacterial assembly in the canine intestinal tract.