Sentences with phrase «most of the adverse events»

In earlier placebo - control clinical studies, most of the adverse events seen in dogs treated with Anipryl ® were also seen in placebo - treated dogs, although rates in placebo - treated dogs were lower.

Not exact matches

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

U.S. National Library of Medicine National Institutes of Health: Among Healthy Children, What Toilet - training Strategy Is Most Effective and Prevents Fewer Adverse Events

Medscape: The report points out that the age of the infant is an important factor in deciding how to treat a mother, because most adverse events associated with drug exposure through breast milk occur in infants younger than 2 months.

Adverse events occurred in more than 10 percent of participants with the most common being somnolence, diarrhea and fatigue and led to discontinuation in 4 percent of patients.

In the RBV - containing arms of the ION studies, the most common adverse events were fatigue, headache, nausea and insomnia.

«The most common adverse event experienced by volunteers was mild itching at the site of tick attachment,» said Dr. Marques.

«Most crop yield simulation models currently in use are not yet suitable for the impact assessment of the various adverse weather conditions or extreme events.

The most common, more severe adverse event (grade 3) was hyperglycaemia, which was observed in 14 % of patients.

Adverse events — most commonly dizziness, fatigue, headache and sleepiness — occurred in 7 - 19 % of patients taking 100 mg and 8 - 16 % of patients taking 200 mg brivaracetam, compared with 3 - 8 % of patients in the placebo group.

Most grade 3 or higher adverse events occurred at similar rates between the two groups, though 10.6 % of cetuximab - treated patients had grade 3 or higher rash acneiform, compared with none in the pemetrexed alone group (P <.0001).

The ocular adverse events most frequently reported in the therapy group were mainly related to the injection procedure, except for the occurrence of intraocular inflammation (accompanied by elevation of intraocular pressure in some patients) that is likely related to GS010, and which was responsive to conventional treatment and without sequelae.

Kidney toxicity is one of the most frequent adverse events reported during drug development.

Subjects with repeated dosing showed an elevated incidence of minor adverse events in comparison to placebo or the single dosing period, most notably transient discomforts such as dizziness and sore throat.

Thirty - two percent of respondents cited adverse events in the child's home life as the most frequent cause of chronic absence.

For example, an adverse event, such as an unfavorable earnings report, may depress the value of equity securities of an issuer held by the Fund; the price of common stock of an issuer may be particularly sensitive to general movements in the stock market; or a drop in the stock market may depress the price of most or all of the common stocks and other equity securities held by the Fund.

With time, they may even lead to chronic allergies, joint disease and cancer — but we'll stick to adverse events that occur within 72 hours of vaccination, because most vaccine reactions that occur outside that timeframe (and many do!)

It is clear that veterinarians are not adequately trained to recognise vaccine reactions, and that although the cause and effect is fairly clear if one understands the potential adverse effects of vaccines, the adverse event reporting schemes don't pick up most of these cases.

Based on the most recent Periodic Safety Update Report (PSUR), which was assessed by the European Medicines Agency (the EU equivalent to the FDA), the incidence of all adverse events remains categorized as «rare.»

In 2009, the U.S. Environmental Protection Agency (EPA) reported adverse reactions from flea & tick control products had doubled since 2005 — mainly due to misapplication.1 After an extensive evaluation of all flea & tick products, the EPA found most adverse drug events were minor, but there were major incidents, too.

If you consider the two most common populations of pets that receive NSAIDs, you can see why there are so many adverse drug events:

When veterinarians advocate these vac - cines, are they aware of the potential for these serious, sometimes fatal adverse events, most of which go unreported?

And most importantly, report these incidents to your veterinarian and the manufacturer of the product so adverse event reports can be filed.

The most common adverse events were vomiting, weight loss, diarrhea or loss of appetite.

The Bismarck route also would have crossed an area considered by federal pipeline regulators as a «high consequence area,» which is an area determined to have the most significant adverse consequences in the event of a pipeline spill.

A paper reporting a «rigorous double blind» study — the VIGOR trial — was submitted to NEJM in 1998, got through peer review at one of the most up - tight journals in the world of medicine, and — by way of cherry - picking the data submitted (selecting out some study subjects whose adverse events histories which, if considered, would've significantly affected the safety profile for rofecoxib and revealed something that Merck really didn't want us prescribers to learn about their «blockbuster» product — was published to be touted by Merck's marketing weevils as solid proofs of Vioxx's tolerability, efficacy, and safety.

A growing body of evidence suggests that stressors associated with war - related events may predispose youth to adverse outcomes.10 - 17 This stream of research is consistent with family systems theory, which suggests that the experiences of a military - connected parent will affect the functioning of youth in that family system.18 Although some studies have considered the impact of military life during wartime, 12,17,19 to our knowledge, most researchers have examined negative outcomes associated specifically with deployments.1, 7,20 These studies have examined the psychosocial functioning of children during the deployment of a parent4, 14 or following 1 or multiple deployments.11, 13,21 Although many military - connected youth fare relatively well despite stressors, these studies concluded that a sizeable proportion appears to struggle with experiences of deployment and other war - related stressors.

The most commonly reported adverse events included pain at the site of injection, headache, fatigue and muscle aches, events also typical for conventional egg - based, inactivated influenza vaccines.