Mouse brain nerve cells (green) making a disease - causing version of the tau protein were grown in lab dishes with supporting brain cells called glia.
Not exact matches
The
mice were also injected with a dye that could illuminate the footprints of new
nerve cell growth in the
brain.
In addition, compared to
mice on a regular diet,
brain cells from animals in the olive oil group showed a dramatic increase in
nerve cell autophagy activation, which was ultimately responsible for the reduction in levels of amyloid plaques and phosphorylated tau.
It reveals specialized
cells in the
brains of
mice dividing to create newborn
nerve cells.
In contrast, the new method used on
mice causes certain
nerve cells to fire at a specific rhythm, generating
brain waves that researchers believe may clear A-beta.
While
mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human
brain is more complicated, and much of that complexity arises from astroglia
cells, the star - shaped
cells that play an important role in the physical structure of the
brain as well as in the transmission of
nerve impulses.
The neurotransmitter acetylcholine is released by
nerve cells in the
brain when people or
mice are under mild stress or concentrating on learning something new.
Using fluorescent antibodies designed specifically to light up the receptor in
mice, the investigators observed it on vagus
nerves, which serve as a main biochemical connection between airway
cells and the
brain.
Adult
mice and other rodents sprout new
nerve cells in memory - related parts of their
brains.
A month after H7N7 or H3N2 infection,
mice had fewer
nerve cell connectors called dendritic spines on
cells in the hippocampus, a
brain region involved in memory.
Scientists made select
nerve cells in
mice's
brains sensitive to light, and then used lasers to activate specific groups of those
cells.
Researchers also studied the
brain tissue of the infected
mice under a microscope and found that the memory problems tracked with changes in
nerve cells.
Two kinds of
mouse glial
brain cells, microglia and astrocytes, making different versions of the APOE protein were grown with
brain nerve cells, or neurons, that make disease - causing forms of tau.
A microscope image shows
nerve cells that relay information from the ear to the
brain in
mice.
They also tested other chemicals known to prevent the other two forms of cellular suicide, but only CGP3466B protected
mouse nerve cells in the
brain from death by cocaine.
In the current study, researchers found to their surprise that most of the
nerve cells in auditory cortex neurons that stimulate
brain activity (excitatory) had signaled less (had «weaker» activity) when the
mice expected and got a reward.
To find out, the research team examined
nerve cells from
mouse brains for clues.
BRANCHING OUT In 1966, researchers thought that the branching ends of
nerve cells (
mouse neurons shown) might store memories in the human
brain.
NERVE PROTECTORS The glowing cells in this micrograph of a mouse's optic nerve help shield electrical signals passing between eyes and b
NERVE PROTECTORS The glowing
cells in this micrograph of a
mouse's optic
nerve help shield electrical signals passing between eyes and b
nerve help shield electrical signals passing between eyes and
brain.
But active
nerve cells in newborn
mouse brains can't yet make this request, and their silence leaves them hungry, scientists report June 22 in the Journal of Neuroscience.
MISS MATCH After paw stimulation,
nerve cells in the
brain of a 7 - day - old
mice become active (top row, left), but blood doesn't show up (bottom row, left).
In both
mouse and fruit fly embryos, Detlev Arendt, an evolutionary biologist at the European Molecular Biology Laboratory in Heidelberg, Germany, has found that
cells involved in forming the
brain and
nerve cord divide into three columns of
cells.
Without the gene, the
mice didn't have Neuroligin - 3 in their
brains, a protein that helps
nerve cells communicate.
The young
mice showed signs of
brain deterioration as well, including inflammation and decreased birthrates of new
nerve cells.
Reported in Neuron, the new method enables researchers to peer deep inside a
mouse's
brain and watch astrocytes» influence over
nerve -
cell communication in real time.
The authors also found abnormalities in the subthalamic nucleus occur earlier than in other
brain regions, and that subthalamic nucleus
nerve cells progressively degenerate as the
mice age, mirroring the human pathology of Huntington's disease.
Previously, Dr. Smeyne and his collaborator Dr. Stacey Schultz - Cherry in the Department of Infectious Disease at St. Jude Children's Research Hospital in Memphis, TN, showed that a deadly H5N1 strain of influenza (so - called Bird Flu) that has a high mortality rate (60 percent of those infected died from the disease) was able to infect
nerve cells, travel to the
brain, and cause inflammation that, the researchers showed, would later result in Parkinson's - like symptoms in
mice.
The drug restored in the
mice normal levels of serotonin, a neurotransmitter communicating messages between
nerve cells in the
brain.
One of Freeman's big projects is working with collaborators to study how
nerve cells in the
brains of
mice respond to touch.
To see what was happening in the
brains of these ankyrin - G mutant
mice, the researchers analyzed the
cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back
nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant
mice than in normal
mice.
Likewise, certain
brain regions of these optogenetically stimulated, post-stroke
mice showed increased levels of proteins associated with heightened ability of
nerve cells to alter their structural features in response to experience — for example, practice and learning.
When investigators at the Stanford University School of Medicine applied light - driven stimulation to
nerve cells in the
brains of
mice that had suffered strokes several days earlier, the
mice showed significantly greater recovery in motor ability than
mice that had experienced strokes but whose
brains weren't stimulated.
VIDEO: 3D images of different Sst interneurons, or type of
nerve cell, in the outer shell, or cerebral cortex, of the
mouse brain.
Different Sst interneurons, or type of
nerve cell, in the outer shell, or cerebral cortex, of the
mouse brain.
Mice exposed to low - dosage of cannabis have more links between
nerve cells in the
brain, compared to those who were not exposed.
Scientists used
mice to study how
nerve cells in thalamic reticular nucleus work during sleep and how they help the
brain concentrate.
When the scientists looked in the
brain of a
mouse with this mutation, they found, again, that MC4R was not on the
nerve cell cilia where it should go to work.
Likewise,
mouse microglia bioengineered to lack EP2 vastly outperformed unaltered microglia, in A-beta-challenged
brains, at such critical tasks as secreting recruiting chemicals and factors beneficial to
nerve cells and in producing inflammation - countering, rather than inflammation - spurring, proteins.
The researchers» findings suggest that Nav1.1 levels in special regulatory
nerve cells called parvalbumin
cells, or PV
cells, are essential to generate healthy
brain - wave activity — and that problems in this process contribute to cognitive decline in AD -
mice and possibly in patients with Alzheimer's.
A microscope image shows the location in the
brain of a
mouse where
nerve cells from the ear enter the
brain and form cup - like synaptic connections with
brain cells.
The researchers also discovered that the integrity of synapses was preserved much better in the olive oil group and the
brain tissue of the
mice that fed olive oil had increased autophagy activation of the
nerve cells.
December 14, 2015
Brain cell death is a possible trigger of multiple sclerosis Multiple sclerosis (MS) may be triggered by the death of brain cells that make myelin, the insulation around nerve fibers, according to research on a novel mouse model developed by scientists from the University of Chicago and Northwestern Medi
Brain cell death is a possible trigger of multiple sclerosis Multiple sclerosis (MS) may be triggered by the death of
brain cells that make myelin, the insulation around nerve fibers, according to research on a novel mouse model developed by scientists from the University of Chicago and Northwestern Medi
brain cells that make myelin, the insulation around
nerve fibers, according to research on a novel
mouse model developed by scientists from the University of Chicago and Northwestern Medicine.
Nerve cells in the
mouse brain that have been labeled with a modified rabies virus and fluorescent proteins.
In the 1960s, it was discovered that large amounts of MSG fed to infant
mice destroyed
nerve cells in the
brain.