Sentences with phrase «mouse studies advance»

Not exact matches

They studied the bone metabolism at the cellular level using advanced imaging and computational techniques, which allowed them to identify 142 metabolites that were significantly altered by more than 1.5 times in the diabetic mice.

High - profile advances, from the Allen Brain Atlas to the Brainbow mouse, have injected an air of excitement into the study of the brain — an atmosphere that has been amplified by big funding initiatives in the United States and abroad.

Early but not advanced forms of atherosclerotic plaques in the vessel wall disappear when the levels of «bad» cholesterol are lowered, according to a study in mice from Karolinska Institutet, Sweden.

As a next step, Daniell hopes to collaborate with Alzheimer's experts at Penn to advance these studies and add a behavioral component to determine whether the CBP - MBP compound not only removes plaques but also improves the memory and functioning of mice with the Alzheimer's disease.

Instead of studying the brain of a person, or a mouse, or even a lowly worm, the two used advanced neuroscience methods to scrutinize the inner workings of another information processor — a computer chip.

A study published March 7th by Cell Press in the journal Cell reveals that a compound derived from fats found in fish oils prevents death in influenza - virus - infected mice, even at advanced stages of disease.

In the new study, published today in Science Advances, Charles Limoli, a molecular biologist at the University of California, Irvine, and colleagues took male mice to a particle accelerator at the NASA Space Radiation Laboratory in Upton, New York.

In a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill.

He mentioned mouse studies by Chris Fiorillo, now at the Korea Advanced Institute of Science and Technology (KAIST), who inserted genetic sequences that code for a light - sensitive protein called channelrhodopsin - 2 into dopamine - producing neurons of mice.

The research, the cover story of this month's Science Advances, builds upon previous studies from Dr. Olson in which CRISPR - Cas9 corrected a single gene mutation that caused DMD in mice.

Two new studies, on pain receptors and a mouse model for congenital blindness, now report significant advances toward the realization of this goal.

«Mouse and human kidney development compared: Findings may lead to advances in the study and treatment of kidney disease.»

The study of these new mouse models means an advance in the knowledge of disease's development mechanisms and an opportunity to implement new therapeutic strategies for patients.

«This is the first study advancing barrier repair that treats symptomatic mice, which more closely mirrors conditions for human patients,» Dr. Garbuzova - Davis said.

Because the mouse and human brains have much in common, co-lead study investigator William Muñoz, an MD - PhD student at NYU Langone, says the team's findings advance the field's understanding of how the brain processes touch, smell, hearing, sight, and taste.

The FDA - approved drug fluoxetine, also known by the brand name Prozac, restored levels of a key neurotransmitter and improved behavior in mice with an autism - like disorder, a new study in the June 21 issue of Science Advances reports.

Instead of studying the brain of a person, or a mouse, or even a lowly worm, the two used advanced neuroscience methods to scrutinize the inner workings of...

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

Because the mouse and human brains have much in common, co-lead study investigator William Muñoz, an MD / PhD student at NYU Langone, says the team's findings advance the field's understanding of how the brain processes touch, smell, hearing, sight, and taste.

Of the 22 patients whose tumors successfully grafted, six died before data from the mice were available, but in 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutations.3

Dr. Jos Jonkers» research group studies the genetic basis of human breast cancer, using advanced mouse models for p53 - induced breast cancer, BRCA1 - and BRCA2 - associated hereditary breast cancer, and E-cadherin mutated invasive lobular carcinoma.

In the study, the researchers tested phenformin as a chemotherapy agent in genetically - engineered mice lacking LKB1 and which had advanced stage lung tumors.

The researchers studied mammary tumors in mice caused by the over production of a protein called Wnt1, which is secreted by tumor cells and is needed to advance tumor growth.

Another mouse preclinical screening trial targeted the symptomatic stage (between 9 and 11 months)[44] and a study with a plant extract [99] used 23 - to 24 - month - old mice, but to our knowledge no chemically defined AD drug candidate has been tried at the more pathologically advanced stage used in this study.

The third interesting advance made in this study is the discovery that mouse iPS cell lines could be established and maintained for 30 passages on HFF cells without exogenous LIF.

The antibodies used in this study includes COX - 2 (Cayman Chemicals, Ann Arbor, MI, USA), STAT6 for Western blot (Cell Signaling Technology, Danvers, MA, USA), for immunofluorescence (IF)(BD Pharmingen, San Diego, CA, USA), for ChIP (Santa Cruz Biotechnology, Santa Cruz, CA, USA), phospho - STAT6 (Cell Signaling Technology), p300 for Western blot, (Upstate, Lake Placid, NY, USA), for ChIP (Santa Cruz Biotechnology), normal rabbit IgG (Santa Cruz Biotechnology), mouse immunoglobulin (Ig) G1, κ Ig (BD Pharmingen), glyceraldehyde -3-phosphate dehydrogenase (Advanced ImmunoChemical, Long Beach, CA, USA), Cy3 - conjugated AffiniPure Goat anti-mouse IgG (Jackson ImmunoResearch, West Grove, PA, USA) and PARP (Cell Signaling Technology).

His lab uses advanced light - sheet microscopy and computational methods to quantitatively study neural development in fruit fly, zebrafish and mouse.

The center also participates in the national «MICROMouse» program, which awards competitive one - year grants up to $ 75,000 for research projects that have the potential to enhance and advance the mission of the MMPC as a resource for scientists using mice to study diabetes and obesity.

This webinar highlights recent advances and future directions using humanized NSG ™ mice with functional human immune cells, to study human infectious diseases including HIV.