Sentences with phrase «mouse studies then»

Not exact matches

In the study, mice were given food until they became obese, and were then fed the drug, which increases the cellular metabolism of obesity - linked white fat cells.

Depending on results from further behavioural studies in mice and humans, the abnormalities could then be treated in parallel with seizures.

Since then, they have studied this protein in flies, mice, zebrafish and humans.

Her main focus has been studying how the central nervous system develops in embryos: in frogs as a graduate student, then in mice as a postdoc at Duke University starting in 1997, and later at U.C. San Francisco when her lab moved to the Ernest Gallo Clinic and Research Center there in 1999.

Since then, Pereira - Smith's team has moved into using genetic techniques in mice to study whether and how senescence is regulated by MORF4 and related genes.

Then in 2015, two studies of mice found evidence of the brain's lymphatic system in the dura.

If a lab is studying the impact of stress on the growth of new neurons, for example, and then it lets mice exercise on a running wheel — which has been shown to spark neuron growth — the study could be jeopardized, Godbout says.

Among dozens of mouse studies, he presented work led by Moderna Co-Founder Kenneth Chien, then at Harvard Medical School in Boston, showing that mice recovering from induced heart attacks survived longer and had stronger hearts when injected with mRNA encoding a protein that drives blood vessel formation — vascular endothelial growth factor (VEGF).

A light guide implanted in a mouse's brain lets researchers stimulate selected neuron sand then study the effect of cells firing out of sync.

The researchers then used a battery of behavioral and biochemical tests to study the mice after weaning.

The scientists then studied the patterns of gene expression in these mice.

Patricia Hunt (then working at Case Western Reserve University) was studying the endocrine environment of the aging ovary in mice.

The scientists then moved on to study mice which had been genetically altered so that their hair cells lacked two of the RFX transcription factors.

Since CGP3466B has already been tested in phase II clinical trials to (unsuccessfully) treat Parkinson's disease and ALS, it is known to be safe for humans, but the researchers caution that many more years of studies are needed to definitively show whether it is effective for preventing cocaine damage, first in mice, then in humans.

In a separate study, Steven Kliewer, a molecular biologist at the University of Texas Southwestern Medical Center in Dallas, and colleagues fed normal mice and transgenic mice that overproduce the hormone a regular diet, then starved them for a day.

For prevention studies, they injected mouse α - syn synthetic preformed fibrils into wild - type, normal mice, as a control, and then immediately treated the mice with Syn303, one of the MAbs used (or IgG, another type of common antibody, for the control mice).

To explore this idea, they induced heart attacks in mice and then studied the fibroblasts to see if the cells expressed markers characteristic of endothelial cells.

Broady's team then studied the effects of NSI on mice injected with one of the six venoms.

In another study, his team found that mice given chow containing trace amounts of arsenic, then exposed to a standard daily dose of ultraviolet light, had higher rates of skin cancers than mice given untainted chow.

They then exposed the mice to light and studied how it affected genes within the brain.

Researchers at the Cells - in - Motion Cluster of Excellence at the University of Münster (Germany) have now developed a method enabling them to better evaluate and study the activity of inflammatory cells in mice: they have succeeded in genetically modifying precursors of immune cells, then increasing their numbers in a test tube and finally tracking them spatially and temporally in living organisms.

But without SCF, the hair in mouse models was gray, and then turned white with age, according to the study.

The study found that after oral feeding, ground cinnamon is metabolized into sodium benzoate, which then enters into the brain, stops the loss of Parkin and DJ - 1, protects neurons, normalizes neurotransmitter levels, and improves motor functions in mice with PD.

«We were then able to show in studies on mice that the same process occurs in living organisms,» says Boris Strilic, first author of the study.

Miller, then - graduate student Sarah DeVos, PhD, and colleagues studied genetically modified mice that produce a mutant form of human tau that easily clumps together.

In a recent study, researchers injected carbon nanotubes into kidney tumors in mice, and then directed a near - infrared laser at the tumors.

Then they studied the mice's lungs microscopically and, using microarrays, measured the expression of many dozens of genes in their lung tissue at 1, 3, and 5 days after infection.

«What we did in this paper is engineer our sensor to be about 15 times better than a previous version, and then compared it against a blood biomarker in a mouse model of ovarian cancer to show that we could beat it,» says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science, a member of MIT's Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science, and the senior author of the study.

In the new study, Mogil told the researchers in his lab to inject an inflammatory agent into the foot of a rat or mouse and then take a seat nearby and read a book.

The mice went through the same shock - conditioning process as in the Mayford study and were then returned to their home cage.

To further determine if manipulating fkbp5 could prevent the abnormal paths of extinction learning, Galatzer - Levy looked at data taken from a mouse study in which they were fear conditioned, given doses of dexamethasone or a placebo, and then put through fear extinction training the following day.

The researchers then studied these same immune cells in mice which had been bred to develop features of Alzheimer's.

The study team then tested UNC0642, which had more favorable pharmacological features, in a mouse model of PWS.

And if you register a study with 20 mice but then only publish results with 13 mice, people are going to wonder what happened to the other seven mice.

Researchers will begin by studying the immune effects of introducing mouse bacteria, and then go on to study the effects of introducing human strains.

In the second study, a team led by Shahin Rafii at Weill Cornell Medicine in New York City used adult mouse cells as their starting material, and then guided them through several steps — including exposure to some of the same gene - activating proteins — to create mature blood stem cells in a petri dish.

«Since then, we studied hunting behavior in [the] red fox and found that they have a preference for N - E during their mousing jumps, and from there it was just a small step to study dogs.

Again, then, there is significant evidence consistent with a role of cellular senescence in age - related lipodystrophy and lipoatrophy, and for the benefits observed in treated mice in these studies to translate into aging humans.

Schenk also revealed some very early information specific to PRX002, the humanized version of the most promising antibody tested in the mouse studies, which was then slated to enter into early - stage human trials.

They will then test in vivo (in animals) their combination of drugs on the best mouse model available to study lipofuscin - mediated retinal degeneration.

(10) The company's scientists also report that when they then injected preformed AS fibrils into the brains of mice, BIIB054 slowed the self - templating spread of AS pathology across the brain (consistent with their cell - culture study), and held much of the ensuing motor dysfunction at bay (9,10)(reducing it «by more than 50 percent» according to a science journalist who was present when they presented results at AD / PD 2017 (11)-RRB-.

Maria Anna Ciemerych began her research with studies focusing at the cell cycle regulation of mouse oocytes and preimplantation embryos (Ph.D. at the University of Warsaw), then investigated the role of the cell cycle regulators - D - type cyclins, in mouse development (Dana Farber Cancer Institute, Harvard Medical School).

He then went on to do his PhD studies at Imperial College under the supervision of Professor Neil Brockdorff on heritable silencing mechanisms during mouse development.

«It's been known for a while that Zika virus in men can find its way into the reproductive organs and may then go on to be sexually transmitted, but this study in mice is the first suggestion that this passage through the reproductive tract may actually be damaging.

To do this, a group of researchers recently used genetic techniques to remove huntingtin from adult mice of different ages, then studied their brains and behavior until old age.

DJ - 1 + / −; PolgWT / MT mice were then bred with each other to produce the cohorts of mice used in this study.

Dear GreenSmoothieGirl: The Oxford - Cornell China Project is irrelevant to us, because Campbell studied rats and mice, and then Chinese people.

And then another study found a significant decrease in the adipose tissue (fat cells) of mice when they were given leucine.

It's good to get studies on different animals — if the study is only on mice but there's several similar ones on humans and rats too, then its fair game.

A 2012 study conducted by Garza et al discovered a link between PGD2 elevation and hair loss, first in mice and then in men.