Sentences with phrase «mtb bacteria»

«The current model of disease is that when Mtb bacteria are inhaled, they reach the end of the lung — the alveolus — and then are ingested by a macrophage, a type of white blood cell that swallows and kills invading bacteria,» Dr. Shiloh said.

«Our study shows that once Mtb bacteria are inhaled, they also can enter the body directly through M - cells that line the airway tissue, and then travel to the lymph nodes and beyond.

Not exact matches

The alterations of the rifampin binding site prevent rifampin from binding to and inhibiting Mtb RNAP, preventing rifampin from killing TB bacteria.

The results show that AAPs inhibit Mtb RNAP through a binding site that does not overlap the rifampin binding site and thus can inhibit rifampin - resistant Mtb RNAP and kill rifampin - resistant TB bacteria.

Intensive efforts also have been underway to develop new, non rifampin - related Mtb RNAP inhibitors that function through binding sites on Mtb RNAP that do not overlap the rifampin binding site and that thus can kill rifampin - resistant TB bacteria.

In experiments using Mtb, the scientists found that mycobacteria without lamA formed far less diverse bacteria with more uniform susceptibility to antibiotics.

The TB bacterium Mycobacterium tuberculosis (Mtb) is estimated to be present in up to a third of the world's population, although active TB only develops in around one in 10 cases.

Dr. Shiloh and his team currently are working to discover the human cell - surface receptors for Mtb that are involved in the bacteria's M - cell translocation, as well as to determine the exact machinery used by the cell to move the bacteria from the surface to the bottom of the cell.

The bacterium that causes tuberculosis, Mycobacterium tuberculosis, or Mtb, previously was thought to infect the body only through inhalation and subsequent infection of cells in the lungs.

The innate system — via stem cells in the bone marrow — mobilizes macrophages, which are a type of white blood cell that swallows and kills invading bacteria like Mycobacterium tuberculosis (Mtb) that causes TB.

For example, Dr. Shiloh said, preventing Mtb from attaching to receptors on the M - cell surface — such as by vaccinating against a bacterial protein — could block the bacteria's entry, infection, and spread to other organs.

About one - third of the global population is infected with the bacteria that cause TB — Mycobacterium tuberculosis, or Mtb — though only a small percentage will develop the actual disease.