Sentences with phrase «mtb cells»
«Thus in our new paper, we postulate that vitamin C is stimulating respiration of the Mtb cells in mice, thus enabling the action of isoniazid and rifampicin.»
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Dr. Shiloh and his team currently are working to discover the human cell - surface receptors for Mtb that are involved in the bacteria's M - cell translocation, as well as to determine the exact machinery used by the cell to move the bacteria from the surface to the bottom of the cell.
The research team, led by Dr. Michael Shiloh, Assistant Professor of Internal Medicine and Microbiology at UT Southwestern, found that microfold cell (M - cell) translocation is a new and previously unknown mechanism by which Mtb enters the body.
The bacterium that causes tuberculosis, Mycobacterium tuberculosis, or Mtb, previously was thought to infect the body only through inhalation and subsequent infection of cells in the lungs.
The innate system — via stem cells in the bone marrow — mobilizes macrophages, which are a type of white blood cell that swallows and kills invading bacteria like Mycobacterium tuberculosis (Mtb) that causes TB.
For example, Dr. Shiloh said, preventing Mtb from attaching to receptors on the M - cell surface — such as by vaccinating against a bacterial protein — could block the bacteria's entry, infection, and spread to other organs.
«Our study shows that once Mtb bacteria are inhaled, they also can enter the body directly through M - cells that line the airway tissue, and then travel to the lymph nodes and beyond.
Although further studies are necessary, potential clinical applications of the team's finding would involve developing methods or drugs that prevent Mtb from entering M - cells.
«The current model of disease is that when Mtb bacteria are inhaled, they reach the end of the lung — the alveolus — and then are ingested by a macrophage, a type of white blood cell that swallows and kills invading bacteria,» Dr. Shiloh said.
Following completion of a massive epitope discovery effort (also supported by an HHS contract), current work on MTB includes development of tools to isolate MTB - specific T cells (supported by the Gates Foundation) and identifying T cell signatures that distinguish three possible infection states: cleared infection, stable latent infection, and latent infection with high risk of progression to disease (in conjunction with a large consortium led by Henry Blumberg at Emory University).
His previous work at IDRI has included investigations into the physiology of the M.tuberculosis (Mtb) cell wall, the development of an overexpression library for high throughput target identification, and the development of target based high throughput screens for potential drug candidates against Mtb.
Mycobacterium tuberculosis (Mtb) DprE1, an essential isomerase for the biosynthesis of the mycobacterial cell wall, is a validated target for tuberculosis (TB) drug development.