Sentences with phrase «multiple mechanisms of resistance»
Multiple mechanisms of resistance to PARPi have been proposed (reviewed in ref.
http://cancerdiscovery.aacrjournals.org/ Not exact matches
«Plants with one type of glyphosate - resistance mechanism make multiple copies of the target site for glyphosate, a gene called EPSPS.
A novel mechanism — similar to how normal tissue stem cells respond to wounding — might explain why bladder cancer stem cells actively contribute to chemo - resistance after multiple cycles of chemotherapy drug treatment.
Antimicrobial resistance arises through multiple mechanisms, one of which is the ability of bacteria to survive DNA damage.
My studies of cancer genomes have led to characterization of multiple pediatric and adult tumor types, to development of methods that identify and characterize changes in genomic heterogeneity, to defining acquired resistance mechanisms to targeted therapies and to designing novel, personalized vaccines for individual patients.
From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.
• explore multiple biological responses to chronic stress (e.g. elevated inflammation, accelerated atherosclerosis, and increased insulin resistance) to elucidate causal mechanisms of adult diseases that are associated with adverse childhood experiences.