Sentences with phrase «muscarinic receptor»
Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine...
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Effects of muscarinic receptor antagonists on cocaine discrimination in wild - type mice and in muscarinic receptor M1, M2, and M4 receptor knockout mice Joseph L, Thomsen M. Behavioural Brain Research.
Scopolamine is a well known competitive muscarinic receptor antagonist that causes reproducible, transient impairments across multiple cognitive domains in healthy animals and non-diseased humans by decreasing central cholinergic neuronal activity [124, 125].
Therefore, the effect of J147 on the cholinergic system was investigated using the muscarinic receptor antagonist, scopolamine, which decreases central cholinergic neuronal activity.
The rationale behind the project is that acetylcholine plays are role in cognitive functioning and that there is a subgroup of schizophrenia patients that have reduced density and M1 receptor binding in the hippocampus and dorsolateral prefrontal cortex that are referred to as «muscarinic receptor - deficit schizophrenia» or MRDS.
First fatty acylated dipeptides to affect muscarinic receptor ligand binding.
Not exact matches
Effects of myo - inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells.
Similar SH3 binding motifs exist in the formins, proteins that function in pattern formation in embryonic limbs of the mouse, and one subtype of the muscarinic acetylcholine receptor.
Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome.
In studies to understand the molecular basis for therapeutic drug action, he showed how tiotropium bromide (Spiriva), an inhaled drug for chronic obstructive pulmonary disease and for uncontrolled asthma, recognizes and blocks the muscarinic 3 (M3) receptor.
Experimental data and computational models suggest that blockade of muscarinic cholinergic receptors impairs paired - associate learning and increases proactive interference (E. DeRosa & M. E. Hasselmo, 2000; M. E. Hasselmo & J. M. Bower, 1993).