Sentences with phrase «mutation frequency analysis»

Not exact matches

A further issue is that tracking mutations through bulk analysis of cells is typically based on certain assumptions as to how mutations arise and what their frequencies mean.

The Reproducibility Project did not attempt to replicate this finding, but subsequent studies have reported the frequency of PREX2 mutations in human melanoma (Hodis et al., 2012; Krauthammer et al., 2012; Marzese et al., 2014; Ni et al., 2013; Turajlic et al., 2012), including meta - analysis of 241 melanomas (Xia et al., 2014).

Bethesda, Md., Wed., May 1, 2013 - A comprehensive genomic analysis of nearly 400 endometrial tumors suggests that certain molecular characteristics - such as the frequency of mutations - could complement current pathology methods and help distinguish between principal types of endometrial tumors, as well as provide insights into potential treatment strategies.

A clustering analysis of mutant allele frequencies suggested that there were four clones (tumor subpopulations) in the primary tumor defined by distinct sets of mutations.

Analysis of larger cohorts will provide information about the frequency and kinetics of PARPi reversion mutations in this patient population.

Dr. Cole's project, «Mechanistic Derivation of Germ Line Mutation by Genome - Wide Mouse Tetrad Analysis,» will help define the global patterns of de novo germ line mutations and the frequencies at which such mutations occur in mice, with the long term goal of understanding the molecular mechanisms underlying germ line mutagenesis and developing strategies to prevent or treat disorders caused by such mutations.