Using a technique called Hi - C, which reveals the interactions between different pieces of DNA, the researchers created a three - dimensional «map» of
the Mycoplasma chromosome.
Not exact matches
The next step is attempting to synthesize the
chromosome of another
Mycoplasma in the laboratory and transferring that, Venter says.
We report the design, synthesis, and assembly of the 1.08 — mega — base pair
Mycoplasma mycoides JCVI - syn 1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are controlled only by the synthetic
chromosome.
Notably, the CRG team, which counted with the expertise in
Mycoplasma from the Serrano's laboratory and the collaboration of the ICREA research professor Marc Marti - Renom at CNAG - CRG, discovered that
Mycoplasma's circular
chromosome is consistently organised the same way in all the cells, with a region called the Origin (where DNA copying begins) at one end of the structure and the midpoint of the
chromosome located at the opposite end.
However, it was thought that these domains would not be found in
Mycoplasma, because its genome is so small and it only makes around 20 different DNA binding proteins responsible for organising the
chromosome, compared to the hundreds made by other bacterial species.