December 1, 2011 Leading expert, Andrzej Jakubowiak, to direct
myeloma program at University of Chicago Medical Center Andrzej Jakubowiak, MD, PhD, an internationally known authority on multiple myeloma, has been appointed professor of medicine and director of the
myeloma program at the University of Chicago Medical Center.
December 6, 2011 Drug combination highly effective for newly diagnosed myeloma patients, study finds A three - drug combination treatment for the blood cancer multiple myeloma compares favorably to the best established therapy for newly diagnosed patients, according to a multi-center study led by Andrzej Jakubowiak, MD, PhD, professor of medicine and director of the multiple
myeloma program at the University of Chicago Medical Center.
Amrita Krishnan, M.D., F.A.C.P., is Director of the Multiple
Myeloma Program at City of Hope.
Not exact matches
Announcing the first ever research
program solely dedicated to the early detection and prevention of Multiple
Myeloma Learn More
«The treatment of multiple
myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medical
myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical
program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple
Myeloma Center, and the R.J. Corman professor at Harvard Medical
Myeloma Center, and the R.J. Corman professor at Harvard Medical School.
«Despite current drugs and use of bone marrow transplantation, multiple
myeloma is still incurable, and almost all patients eventually relapse,» says co-principal investigator and multiple
myeloma specialist Craig Hofmeister, MD, MPH, assistant professor of medicine and a member of the OSUCCC — James Translational Therapeutics
Program.
We have one of the most comprehensive CAR T cell
programs in the world, with 14 CAR T clinical trials ongoing and plans to open numerous additional trials in the coming year, including for patients with multiple
myeloma, prostate cancer, liver cancer and breast cancer.
Bluebird Bio (NASDAQ: BLUE) and Novartis (NYSE: NVS) have the most advanced CAR - T
programs for
myeloma, with Bluebird and partner Celgene (NASDAQ: CELG) planning a pivotal study this year.
As Director of the Hematologic Malignancies / Blood and Marrow Transplantation
Program, Dr. Collins is proud that UT Southwestern offers the best care in the area for patients with leukemia, lymphoma, and
myelomas.
This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple
myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression
program.
The KEYNOTE - 183, KEYNOTE - 185, and KEYNOTE - 023 trials evaluating the
programmed death 1 (PD - 1) inhibitor pembrolizumab in combination with pomalidomide or lenalidomide for patients with multiple
myeloma were placed on hold due to the increase in deaths on the pembrolizumab arms of KEYNOTE - 183 and KEYNOTE - 185 trials.