Sentences with phrase «nab responses»

Autologous tier 2 NAb responses in animals immunized with native - like (SOSIP.664) trimers or non-native uncleaved gp140s.

We mapped the BG505 NAb responses using various techniques, including a large panel of Env - pseudotyped virus mutants.

The rabbit tier 2 and tier 1 NAb responses to the BG505 SOSIP.664 trimers were uncorrelated.

Although an autologous tier 2 NAb response is not sufficient for vaccine protection against HIV - 1, it may be a necessary step in various strategies intended to induce bNAbs.

Thus, our findings indicate that native - like trimers represent a promising starting point for the further development of recombinant Env immunogens intended to broaden the NAb response.

A second trimer, B41 SOSIP.664, also induced a strong autologous tier 2 NAb response in rabbits.

«As eliciting a highly diverse immune response may be favorable to providing protection against incredibly diverse HIV - 1 variants in global circulation,» the researchers conclude that their study «supports further investigations of the molecular and functional characteristics of the virus - antibody interplay in superinfected individuals, as superinfection may provide insight to the development of a diverse Nab response with multiple epitope specificities.»

Not exact matches

Of note, the current study is part of a recent surge in NYU Langone findings on pancreatic cancer, including studies on how first - responder cells turn off the immune response, the role of the drug nab - paclitaxel in tumor biology, cancer cells» unique fuel sources, and how immune cell infighting drives the disease.

The autologous tier 2 NAb titers to both SOSIP.664 trimers were greater than any such responses previously observed using various uncleaved gp140 proteins, including the BG505 version used in this study.

BG505 SOSIP.664 trimers consistently induced potent NAbs against the autologous tier 2 virus in rabbits and similar but weaker responses in macaques.

Tier 2 NAbs recognized conformational epitopes that differed between animals and in some cases overlapped with those recognized by broadly neutralizing antibodies (bNAbs), whereas tier 1 responses targeted linear V3 epitopes.

The dual PI3K / mTOR inhibitor NVP - BEZ235 enhances nab - paclitaxel antitumor response in experimental gastric cancer.

Focused on two creative forces, both «De Palma» (A24) and «The Music of Strangers: Yo - Yo Ma and the Silk Road Ensemble» (The Orchard) nabbed decent response in their initial two - city debuts.

Given the box office numbers and the overwhelmingly positive response from fans and critics alike (Wonder Woman is the first film in the DCEU to nab a «Certified Fresh» rating from Rotten Tomatoes), it looks like DC may be on the verge of righting its cinematic ship.

I know I'll be jumping in just to nab those common Trophies, but something tells me (based on the critical response) that this is the type of game in which I'll probably get lost.

In an article for Levo League, Alan Carniol says «When you walk into an interview mentally prepared, it will show in your responses, your confidence, and most importantly, your desire to nab the job.»