«This is the best example that NF1 is a tumor suppressor,» says David Viskochil, a geneticist at the University of Utah, although he cautions that the case is not yet closed: There still could be other genes that play a role in
NF tumor development.
For this study, Guttridge, first author David J. Wang, who developed many of the study's concepts, and their colleagues monitored
NF - kB activity during
tumor development using mouse embryonic fibroblasts and two mouse models.