Sentences with phrase «nras on the cell proliferation»

«For infectious diseases, antibiotic susceptibility testing based on cell proliferation has been extremely effective for many decades,» Manalis says.

Research fields are diverse, including basic research on cell proliferation, analysis of tumour cells and tissues to detect gene mutations, and identification of potential therapeutic targets in cancer.

Effects of miR -145-5p through NRAS on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K / AKT pathways.

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion.

Removing two small proteins that put the brakes on cell proliferation in separate tissues can have deadly consequences, according to HHMI investigator James Ihle and colleagues at St. Jude Children...

The effect of a novel antagonist of growth hormone releasing hormone on cell proliferation and on the key cell signaling pathways in nine different breast cancer cell lines.

These data would suggest strong suppressive properties of RIPK2 inhibitor 1 and, to some extent, inhibitor 2 on cell proliferation.

From another perspective (regarding effects on cancer): since estrogens have 1000 times stronger effect on cell proliferation than phytoestrogens, the overall effect may be positive (also shown in several studies).

Effects of Pinus Massoniana Bark Extract on Cell Proliferation and Apoptosis of Human Hepatoma Bel - 7402 Cells.

Not exact matches

Boldrini says that future research on the aging brain will continue to explore how neural cell proliferation, maturation, and survival are regulated by hormones, transcription factors, and other inter-cellular pathways.

When those cells were placed on a standard wound assay (for measuring properties like cell migration and proliferation), they moved unusually fast.

One of the team's new biosensors is made from a nanoplasmonic material that is able to accommodate a large number of cells on a single substrate and to monitor cell proliferation, a fundamental process involving cell growth and division, in real time.

Unlike the differential effect on Treg cell proliferation following PD - L1 blockage, the researchers observed an increase in the proliferation of killer T cells from all HIV study groups, regardless of their viral load.

Schematic illustration of cells (blue mountain - like shapes) on top of nanoscale mushroom - like structures with silicone dioxide stems and gold caps, which have the potential to detect cell proliferation in real - time.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

Regulating and removing proteins is vital for all cells, but cancer cells are highly dependent on their protein production machinery to fuel their proliferation.

As an example, he cited his previous research on baked purple potatoes that have compounds that help suppress chronic intestinal inflammation elevated from a high - calorie diet and stem cell proliferation, which are linked to both colitis and colon cancer.

The authors believe theirs is the first study to show that mouse mammary gland tissues are sensitive to a mixture of 23 commonly used UOG chemicals, with dose - specific effects on tissue morphology, cell proliferation and induction of intraductal hyperplasias, an overgrowth of cells considered a marker for future breast cancer risk.

This antibody activates an integrin on the cell surface of basal progenitors and thus stimulates their proliferation,» explains Denise Stenzel, who headed the experiments.

«The current study was designed to determine the effect of inhibition of platelet activation and function by aspirin therapy on colon and pancreatic cancer cell proliferation,» the researchers wrote.

Haotian Zhao, Ph.D., is the lead author on the study titled «Sonic Hedgehog promotes proliferation of Notch - dependent monociliated choroid plexus tumour cells.»

«Since we were genetically deleting the ERK1 / 2 pathway, we expected to see less cell proliferation,» said Petrus R. de Jong, MD, PhD, a co-first author on the paper.

EGFR, present on the cell membrane, is involved in cell proliferation and the development of dermis, lung, and digestive tissues.

The positively charged and neutral nanoparticles mildly inhibited stem cell proliferation but had no effect on their differentiation into bone cells.

They then used human stem cells derived from bone marrow that would normally become bone cells to test the effects of the nanoparticles on stem cell proliferation and differentiation.

The nanoparticles with the negative biomolecules on their surface promoted stem cell proliferation but suppressed «matrix mineralization»: the process that leads to the deposition of minerals into the bone's scaffolding, which makes bones strong.

Students in the UBC program engage in a wide range of research: molecular mechanisms underlying cell proliferation in cancer or cell death in stroke; relating gene mutations to disease mechanisms; the social factors that determine access to health care for women living on the street.

McKay and Tsai conclude that nucleostemin is involved in regulating the proliferation of both stem cells and at least some types of cancer cells, they reported at a meeting here on 20 November and in the December issue of Genes & Development.

We have observed on several occasions that, for the majority of endothelial cell lines, the transfer to 37 °C conditions for 72 h correlated with a 50 % reduction in cell proliferation, a value that continued to decrease with time.

According to Whitehead Institute researchers, protein production or translation is tightly coupled to a highly conserved stress response — the heat shock response and its primary regulator, heat shock factor 1 (HSF1)-- that cancer cells rely on for survival and proliferation.

To support their rapid proliferation, cancer cells must synthesize a large number of proteins, putting a strain on the ER to keep up with its heavy workload of properly folding proteins.

Next, because KLF4 is involved in self - renewal of stem cell, we also examined the effect of both miR - 7 and KLF4 on proliferation of CSCs by MTS assay and found that miR - 7 was capable of blocking the growth of CSCs, whereas ectopic expression of KLF4 significantly mitigated this effect of miR - 7 (Fig. 4C).

CAMBRIDGE, Mass. — Protein production or translation is tightly coupled to a highly conserved stress response that cancer cells rely on for survival and proliferation, according to Whitehead Institute researchers.

«The anti-tumor immune response with CDK4 / 6 inhibition was somewhat unexpected — some had previously thought that CDK4 / 6 inhibitors would block anti-tumor immunity, due to effects on T cell proliferation, but our findings demonstrate quite the opposite,» DeCristo states.

Better understanding of the beta - cell proliferation process eventually may lead toward therapies for diabetes patients, whose supplies of these cells often shrink over time, says Rohit Kulkarni, M.D., Ph.D., a Joslin Senior Investigator and senior author on a paper about the work published in the journal Cell Metabolcell proliferation process eventually may lead toward therapies for diabetes patients, whose supplies of these cells often shrink over time, says Rohit Kulkarni, M.D., Ph.D., a Joslin Senior Investigator and senior author on a paper about the work published in the journal Cell MetabolCell Metabolism.

In search of a mechanism behind the finding that HIV / gp120 reduced proliferation of aNPCs, the scientists studied the effect of the protein on the cell cycle.

The paper «MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition» was published by Cell Reports on April 10, 2018.

Previous studies of beta cell proliferation generally have focused on mechanisms that kick off the cell cycle that leads to successful cell division.

Effects of microRNA - 211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice.

Effects of dehydroepiandrosterone on proliferation and differentiation of chromaffin progenitor cells.

Jens - Christian Roeper (Eaton, MPG)-- «The influence of cell mechanics, cell - cell interactions and proliferation on epithelial packing» (2009)

The Institute is currently running on a Site License by Flowjo, a flow cytometry data analysis software package which offers a range of analysis platforms that includes compensation, cell cycle, proliferation studies and kinetics.

The researchers analyzed the expression of PD - L1 on malignant cells in lymphoproliferative disorders and how it contributes to malignant cell proliferation.

To this end, we are focusing on two aspects of β - cell regeneration: enhancing β - cell proliferation in vivo and stimulating the differentiation of new β - cells from endogenous progenitors in the pancreas.

We have undertaken a genome - wide functional screen on a mouse muscle cell line and identified hundreds of molecules implicated in the fusion of this cell line, with no effect on their proliferation or differentiation.

[3] H. Lin et al., «Influence of decellularized matrix derived from human mesenchymal stem cells on their proliferation, migration and multi-lineage differentiation potential,» Biomaterials, 33:4480 − 9, 2012.

Initial studies demonstrated that ligation of 4 - 1BB on T cells could deliver costimulatory signals resulting in either increased proliferation or enhanced cytokine secretion and also control clonal expansion and differentiation of effector and memory T cells.

Boldrini says that future research on the ageing brain will continue to explore how neural cell proliferation, maturation, and survival are regulated by hormones, transcription factors, and other inter-cellular pathways.

Runaway cell proliferation is driven by accelerators, or oncogenes, that are stuck on go — in collusion with broken brakes, or tumor suppressors, that can't control a tumor's pedal - to - the - metal growth.

mTOR - rictor complex (composed of mTOR, rictor, and GβL) is not rapamycin sensitive and modulates cell survival and proliferation by direct phosphorylation of AKT on Ser473 and by facilitating AKT phosphorylation on Thr308 by PDK1 in vitro (13).