Sentences with phrase «nsclc tumor location»

After adjusting for age, tumor location, and stage, researchers from Cleveland Clinic's Dermatology & Plastic Surgery Institute discovered that women diagnosed with malignant melanoma during their pregnancy or within one year of giving birth were 5.1 - times as likely to die, 6.9 - times as likely to experience metastasis, and 9.2 - times more likely to have a recurrence.

Moreover, primary tumor locations should be carefully considered when deciding treatment intensity in metastatic and locoregional settings, and should represent an important stratification factor for future adjuvant studies,» the article concludes.

«Can this technique provide both EGFR mutation status information at the molecular level and precise anatomical information such as size, shape, NSCLC tumor location (s), and their relationship with adjacent structures?.»

«In fact we found no link between cell phone usage and temporal lobe tumors, nor was there any association between handedness and tumor location.»

Each chart was reviewed for patient demographics, presenting symptoms and signs, tumor location and size, imaging findings, extent of surgical resection, histopathological findings, radiographic follow - up, tumor recurrence, and clinical outcome.

Clinical, histopathological, and molecular variables included patient age, gender, extraocular extension, tumor location (ciliary body or not), optic nerve invasion, angiotropism, neurotropism, melanoma cell type, BAP1 mutation, and monosomy 3.

The primary tumor location was an independent prognostic marker in patients with RAS wild - type metastatic colorectal cancer after adjusting for age, gender, synchronous / metachronous disease, consensus molecular subtype, and microsatellite instability and molecular status, according to the results of an analysis (abstract 3503) of data from CALGB / SWOG 80405 presented at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting.

The primary tumor location was an independent prognostic marker in patients with RAS wild - type metastatic colorectal cancer after multivariable adjustment.

In an initial analysis of left - compared with right - sidedness, the researchers determined primary tumor location in 782 patients; 472 had left primary and 256 had right primary.

Doctors in both human and animal medicine use x-ray to find fractures of the bone, tumor location, and foreign object identification and even to diagnose pneumonia and heart disease.

The selection of a radiation dose is based on considerations of tumor type, tumor location, and on the tolerance of the normal tissues surrounding the tumor.

Depending on the tumor location and the advanced nature of many cases, many drugs, including L - aspariginase, Vincristine, Prednisone, Cyclophosphamide, and Doxorubricin may be used in sequence.

The most prevalent tumor location in dogs is the skin with 20 — 30 % of these being malignant.

Prognosis is variable and depends on many factors including tumor location, histiologic grade and clinical stage.

Factors such as age, overall health, chemo and / or radiation if needed, and tumor location will need to be considered.

In some tumor locations, especially for suspected brain tumors, a biopsy diagnosis is not required for consideration of radiation therapy.

Other clinical signs vary, depending on the tumor location and the involvement of normal adjacent tissues.

As in dogs, treatment and prognosis will be determined by tumor location.

Not exact matches

Because of its location in your head, these tumors can press on the nerves that lead to your eyes, causing vision problems if they grow too large.

However, some areas that can resemble blood vessel tumors — called hemangiomas — may need treatment because of their location.

After EZH2 enzymes rise, their levels taper off, and then, the scientists found two to three-fold increases in a protein called DNMT1, which maintains DNA methylation in the «start» location of a variety of tumor suppressor genes that normally suppress cell growth.

Breast cancer tumors can fuse with blood vessel cells, allowing clumps of cancer cells to break away from the main tumor and ride the bloodstream to other locations in the body, suggests preliminary research.

In the spring, the U.S. Food and Drug Administration approved an antibody that is the first cancer therapy based on a tumor genetic biomarker instead of a location in the body.

Milovancev notes that future, larger studies that categorize results by factors that might influence tumor - free margin length — such as tumor grade and location — are likely to lead to more refined preoperative surgical planning.

The researchers also report that radiation sensitivity may be dependent on the anatomic location of the tumor metastasis.

This is one of the first research studies to highlight the importance of the location of the metastasis as well as the location of the original primary tumor, in predicting response to radiation therapy.

Although mutations can occur anywhere in the human intestine, certain types of colorectal cancer tend to develop in particular locations, suggesting that additional, nongenetic factors contribute to tumor growth and dictate where polyps appear.

The research team also tried the GD2 CAR - T therapy in mice with human spinal cord and thalamic tumors implanted in their respective anatomical locations.

«If we could load these virus shells with a different cargo, say a drug, and target it to a particular place in the body, such as a tumor, it could then deliver the drug to just that specific location, making the drug more effective, or reducing side effects,» Lawrence said.

When the scientists inserted human colorectal cancer cells into zebrafish embryos and allowed them to grow for 4 days, the resulting tumors showed three hallmarks of human solid tumors: rapid cell division, formation of blood vessels to supply nutrients, and the ability to spread to other locations in the body.

«With 18F - MPG PET / CT imaging, we were able to quantitate EGFR - activating mutation status in NSCLC patients (primary tumor or metastatic) and directly determine / visualize the location (s) and morphology of the NSCLCs.»

This location represents a particular challenge for surgeons, since the tumors are technically difficult to access and, because of the anatomically constricted space in the lesser pelvis, the view of the operating area is restricted.

There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor.

Bone metastases happen when cancer cells travel from the primary tumor site to the bone, establishing a new cancer location.

Another important aspect of the green - light KTP laser approach, Zeitels adds, is that biopsy and treatment of patients whose cancer involves a single vocal cord usually can be accomplished in the same procedure, whereas radiotherapy requires a prior biopsy to determine the extent and location of the tumor, followed by daily radiation treatments over approximately six weeks.

«While the tumor cells dock to the prepared locations according to the key - lock principle, the remaining cells are simply washed away,» Hirtz explains the principle.

Because different types of tissue absorb emissions from the nanotubes differently, the scanner took readings from many locations to triangulate the tumor's exact location, as confirmed by later MRI scans.

Cancer metastasis, when tumors spread from their primary location, is almost always deadly, so patients need anti-metastatic therapies.

This ability allows drugs to directly target locations they would otherwise be unable to, such as the heart of tumors.

But because the human eye isn't sensitive to near - infrared light, surgeons have to use a special camera to see the glow and identify the tumor's precise location.

The investigators also identified instances in which the genetic profiles of metastases were similar to those of only some cells in the primary tumor, suggesting that those cells were the source of the metastases, and other cases in which the genetic profiles of metastases from the same primary differed depending on their location.

Rather than simply identifying a cancer by location or tissue type, researchers now use advanced molecular profiling tests to characterize tumors, the proteins they express and the novel mutations they develop — known as neoantigens.

Our findings suggest the location of spread is less important than the amount of tumor that is present before treatment,» says the study's lead investigator, Richard W. Joseph, M.D., an oncologist at Mayo Clinic in Florida.

«Tumors located at the base of the skull are particularly challenging to treat due to the location of delicate anatomic structures and critical blood vessels,» said neurosurgeon Clark C. Chen, MD, PhD, UC San Diego Health System.

As detailed in a recent study by Dr. Margulis in The Journal of Urology, «Patients with the disease who undergo surgery have a mortality rate that can be as high as 10 percent, depending on the location of the tumor and its growth into the venous system.

Therefore, the MRI signal indicated the location of MMP - 2, and the tumor.

Information obtained via single - cell sequencing from cells sampled from each core indicate the likely location of a cancerous tumor (dotted lines encompassing cores 2, 3 and 6).

«For example, mouse mammary tumors shared a signaling pathway that is found in human lung cancer and controls how cells reproduce and move from one location to another.»

These studies revealed that the void's physical characteristics — the type and location of missing bone — were consistent with a fibrous dysplastic neoplasm, a tumor caused by a bone growth disorder, the scientists report online today in PLOS ONE.

Although MRI can be performed without contrast or enhancing agents, the addition of such agents is often critical for obtaining the detailed images needed for physicians to find the precise location of brain tumors.