Not exact matches
Phase I funding — which allows up to $ 250,000 for an academic idea, such as decoding the genetic sequence
of a protein or studying targeted drug delivery by
using magnetic
nanoparticles — is available from federal funding and foundations.
Cambridge, MA — February 6, 2017 — Aura Biosciences, a biotechnology company developing a new class
of therapies to target and selectively destroy cancer cells
using viral
nanoparticle conjugates, announced today that the U.S. Food and Drug Administration (FDA) has cleared the investigational new drug application (IND) for the company's lead program, light - activated AU - 011 in ocular melanoma (OM).
Cambridge, MA — December 21, 2017 — Aura Biosciences, a biotechnology company developing a new class
of therapies to target and selectively destroy cancer cells
using viral
nanoparticle conjugates, announced today that it closed a $ 30 million Series C financing.
Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class
of therapies to target and selectively destroy cancer cells
using viral
nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical trial
of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment
of ocular melanoma, a rare and life - threatening disease.
Metal oxides such as zinc oxide and titanium dioxide are increasingly being
used in sunscreens and cosmetics in the form
of nanoparticles — microscopic particles
of matter measured on the nanoscale.
Antimicrobials such as
nanoparticles of silver or titanium dioxide can be
used in packaging to prevent spoilage
of foods.
The researchers
used an ultrastable, variable - temperature stage in an aberration - corrected scanning transmission electron microscope to subject an array
of size - selected gold
nanoparticles (or clusters) to temperatures as high as 500 °C while imaging them with atomic resolution.
«We envision that these photo - responsive polymer - capped gold
nanoparticles could one day serve as nano - carriers for drug delivery into the body
using our robust and reversible process for assembly and disassembly,» said Zhiqun Lin, a professor in the Georgia Tech School
of Materials Science and Engineering.
«We envision that our
nanoparticle therapy could be
used to speed the healing
of all sorts
of wounds, including everyday cuts and burns, surgical incisions, and chronic skin ulcers, which are a particular problem in the elderly and people with diabetes,» said study co-leader David J. Sharp, Ph.D., professor
of physiology & biophysics at Einstein.
These new, non-invasive tools — representing significant advances related to positron emission tomography (PET), 3 - D microscopy and the
use of magnetic fields and
nanoparticles to remotely control targeted cells...
As a proof
of concept for this study, the researchers tested the plant virus - derived
nanoparticles with a nematicide called crystal violet, which has been
used to kill nematodes on skin but not in agriculture.
This clinical study, published in the Proceedings
of the National Academy
of Sciences, tested the possibility
of imaging inflammation in the pancreas
of human volunteers
using ferumoxytol, a coated iron
nanoparticle approved by the FDA as an iron replacement therapy, and MRI.
«We
use biological
nanoparticles — a plant virus — to deliver a pesticide,» said Paul Chariou, a PhD student in biomedical engineering at Case Western Reserve and author
of a study on the process published in the journal ACS Nano.
The team demonstrated that cell sex considerably influenced cellular uptake
of nanoparticles and found that cells from men and women responded differently to reprogramming techniques
used to enhance the ability
of the cells to differentiate into a greater variety
of cell types.
The catalyst was synthesized from chloroauric acid
using glutathione as a capping agent to prevent
nanoparticle aggregation, resulting the formation
of small size
of gold
nanoparticles.
On / off switching
of hydrogen production was achieved
using the
nanoparticle catalyst because it could be easily separated from its organosilane substrate by filtration.
«
Use of the
nanoparticle increases soil diffusion while decreasing the risk
of leaching and runoff, reducing the amount
of chemical in food crops and reducing the cost to treat crops.»
In a paper published in the current online issue
of the journal Small, titled «Immune Cell - Mediated Biodegradable Theranostic
Nanoparticles for Melanoma Targeting,» the researchers report the
use of a novel biodegradable and photoluminescent poly (lactic acid)
nanoparticle, loaded with melanoma - specific drugs with immune cells as the
nanoparticle carriers.
«For years, researchers have focused on delivering more chemotherapy drugs into cancer cells
using nanoparticles, without targeting the root
of drug resistance,» He said.
They
use a near - infrared laser beam, which can penetrate deep — in this context, deep means a centimeter or two — into the tissue, where a
nanoparticle turns the near - infrared light into blue light, and that directs the activity
of genetically engineered immune cells.
Their research, published online Sunday in Nature Nanotechnology, involved the
use of cobalt oxide
nanoparticles to split water into hydrogen and oxygen.
A «Trojan horse» treatment for an aggressive form
of brain cancer, which involves
using tiny
nanoparticles of gold to kill tumour cells, has been successfully tested by scientists.
To address this challenge, our research group is
using nanoparticles not only to deliver more chemotherapy drugs to the target site within cancer cells, but also to compromise the function
of the efflux pumps and thereby significantly improve safety and efficacy
of cancer therapy.»
Scientists at the University
of Florida Particle Engineering Research Center and personal products manufacturer Kimberly - Clark recently found an answer by coating silica
nanoparticles with copper ions, a potent odor - fighting combination that could be
used in powders and spritzes, mixed with cat litter, or embedded in products like garbage bags.
So did
using much larger particles
of cobalt - chromium in place
of the
nanoparticles.
Magnetotactic bacteria can even sense the earth's magnetic field by making
use of magnetic
nanoparticles in their interior that act as an internal compass.
The technique can be applied in myriad ways, some
of which include droplet - based microreactors (devices
used in chemical synthesis),
nanoparticle synthesis, tissue engineering, drug discovery and drug delivery monitoring.
«What's unique about this paper is that we show not the
use of metal particles, not the
use of metal
nanoparticles, but the
use of atoms,» Tour said.
In earlier work, Demir Akin
of Stanford University and his colleagues
used antibodies and
nanoparticles to attach molecules
of DNA to weakened Listeria monocytogenes, which is a bacterium responsible for many cases
of food poisoning.
To create a new dengue virus vaccine, Stefan Metz, Shaomin Tian in the laboratories
of Aravinda de Silva, Chris Luft and Joe DeSimone at the University
of Carolina, Chapel Hill, USA designed
nanoparticles of various shapes and sizes
using Particle Replication in Non-wetting Template (PRINT) technology.
Scanning tunneling microscopy, which produces images
of individual atoms on a surface, was
used to view the behavior
of the platinum
nanoparticles on the graphene.
The
nanoparticles were 30 - nanometre - wide beads
of surgical cobalt - chromium alloy, a material
used in much larger pieces to make surgical implants such as hip prostheses.
An industry group, the Silver Nanotechnology Working Group, said that there has been a long history
of safe, regulated
use of ionic silver, which «suggests that the EPA is adequately managing the risks
of silver
nanoparticles.»
Wilson, the sporting goods manufacturer, has nanoengineered layers
of clay to double the playing life
of its Double Core tennis balls; L'Oréal
uses nanoscale particles and capsules in their cosmetic creams that allow replenishing ingredients to penetrate deep into the skin; and the Australian company Advanced Powder Technology has created Zinclear, a translucent zinc oxide sunblock composed
of nanoparticles as small as the tiniest known viruses.
The experimental pilot study evaluated the
use of magnet - directed
nanoparticles containing the local anesthetic drug ropivacaine (MNP / Ropiv) to produce anesthesia
of the limbs.
A technique
using anesthesia - containing
nanoparticles — drawn to the targeted area
of the body by magnets — could one day provide a useful alternative to nerve block for local anesthesia in patients, suggests an experimental study in the April issue
of Anesthesia & Analgesia, official journal
of the International Anesthesia Research Society (IARS).
Magnet - directed
nanoparticles have previously been
used for targeted delivery
of chemotherapy drugs.
To demonstrate one potential
use of the
nanoparticles, the research team
used them as advanced catalysts for ammonia oxidation, which is a key step in the production
of nitric acid (a liquid acid that is
used in the production
of ammonium nitrate for fertilizers, making plastics, and in the manufacturing
of dyes).
The second visualization was a movie captured at 23,000 - times magnification that revealed the movements
of a group
of nanoparticles reacting to an electron beam, which mimics the effects
of the infrared radiation
used in cancer therapies.
«
Using our new technique, we could not only see that individual
nanoparticles showed different extents
of reaction at a given time, but also how the reaction worked its way through the interior
of each
nanoparticle,» Cabana said.
The researchers
used a coherent, nanoscale beam
of X-rays generated by the high - flux synchrotron accelerator at the Advanced Light Source to interrogate each
nanoparticle.
In general, catalysts are rare metals (platinum, for example), which are often
used in the form
of nanoparticles.
The produced aerosol is directed over the heated substrate
using a stream
of nitrogen gas resulting into a polycrystalline thin film grown on the chalcopyrite substrate over time with embedded
nanoparticles of platinum.
Clever
use of a microscopic resonator can quickly measure the masses
of proteins and gold
nanoparticles.
Use of nanoparticles in many applications, e.g. for catalysis, relies on the surface area
of the particles.
The tiny
nanoparticles used for catalysis often consist
of only a few platinum atoms.
Rubner
used nanoparticles made
of silica, the same material glass is made
of, to create a coating with a rough surface.
Now, Johns Hopkins researchers report they have
used nanoparticles to successfully deliver a new therapy to glioma cells in the brains
of rats, prolonging their lives.
Fiering is testing the
use of heat in combination with
nanoparticles.
Instead
of simply applying an antibiotic to the teeth, they took advantage
of the pH - sensitive and enzyme - like properties
of iron - containing
nanoparticles to catalyze the activity
of hydrogen peroxide, a commonly
used natural antiseptic.