Sentences with phrase «nasonia ortholog»

The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

Future research will aim to describe the precise molecular mechanisms of action, as well as to generate other orthologs that boost efficacy while reducing side effects.

The team produced an ortholog of the uropathogen - derived protein.

Most orthology determination methods make use of sequence comparisons: the amino acid sequences of all proteins in two species are compared with each other, and the two sequences that are most similar are considered to be orthologs.

The 2485 introns with orthologs available in the two outgroup Palaeognathae species ranged from exhibiting no conflict to exhibiting considerable conflict (up to 950 genes or 38 %) for some branches of the TENT (Fig. 3A, blue numbers, and Fig. 5C).

«Missing» denotes the case in which an ortholog is not present for any taxa or is present for only one taxon, and hence monophyly can not be determined.

For ~ 13,000 (low - coverage genomes) to ~ 18,000 (high - coverage genomes) annotated genes across avian species (44), phylomeDB inferred orthologs for 94.58 % of them and these agreed with the synteny - based orthology of the 8251 protein - coding genes of the TENT by 93 %.

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

We were able to identify 3,771 ortholog pairs by sequence similarity and investigated the ortholog pair alignment length.

All human and mouse orthologs are one to one.

Gene expression divergence levels were obtained from [71] and were measured in terms of the number of commonly co-expressed genes between human and mouse one to one orthologs.

Analysis and Classification of Human Herpesviridae Proteins Using Domain - Architecture Aware Inference of Orthologs (DAIO)

Their analysis revealed 104 differentially regulated genes that have known orthologs in the OA - susceptible fly D. melanogaster.

Of special note today: gut microbiota species expressing orthologs of human Ro60 might be involved in triggering and sustaining chronic autoimmunity in lupus; The portal vein blood microbiome in patients with liver cirrhosis; A randomized clinical study suggests dietary promotion of short chain fatty acid producing gut microbes as an effective treatment for type 2 diabetes; and the sexual dimorphism of root, flower and leaf microbiomes in the wild strawberry plant

Although CRISPR is incredibly useful for generating mutations by NHEJ and generating small mutations with HDR, when it comes to larger scale genome editing, such as replacement of a mouse gene with its human ortholog (greater than 5 kb), it remains to be seen whether CRISPR is as robust as conventional gene targeting.

* Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus — Teri M. Greiling — Science Translational Medicine

Reduced expression of the Caenorhabditis elegans p53 ortholog cep - 1 results in increased longevity.

Serena Bielli (Dahmann, MPG)-- «Characterization of the EGFL7 / 8 ortholog during Drosophila oogenesis» (2006)

Bottom 10 % CCGs are the genes with the least amount of co-expressed orthologs shared between human and mouse, these genes are likely to have divergent expression patterns between both species.

Their analysis revealed 104 differentially regulated genes that have known orthologs in the OA - susceptible fly

In rice, CYP724B1, encoded by the bsl1 ortholog D11, and CYP90B, encoded by OsDwf4, are partially redundant for C - 22 hydroxylation and the loss - of - function double mutants in OsDwf4 and D11 exhibited severe dwarfism and malformed, erect leaves (Sakamoto et al., 2006).

In addition, a number of key developmental regulators were expressed at higher levels in bsl1 - 1 mutants, including orthologs of classical genes from maize that specify AM identity and determinacy (e.g., bd1 [Chuck et al., 2002] and ramosa1 [Vollbrecht et al., 2005]-RRB-, that pattern lateral organ development (e.g., narrow sheath1 [Scanlon et al., 1996] and yabby10 [Juarez et al., 2004]-RRB-, and those implicated in carpel repression in maize tassels (e.g., grassy tillers1 [Whipple et al., 2011], tasselseed 1 [Acosta et al., 2009], and tasselseed 2 [Irish and Nelson, 1993]-RRB-(Table 2).

The ortholog genes that were found to be associated with cartilage development, along with bmp which acts as a key member gene, are known to be involved in the Wnt signaling pathway (Kim et al., 2013; Lin & Hankenson, 2011).

Furthermore, orthologs of genes controlling pistil retention in maize were misregulated in bsl1 - 1 mutants.

To test this, we performed in situ hybridizations using a probe designed to the S. viridis ortholog of the maize knotted1 (kn1) gene, a key marker of meristem maintenance (Kerstetter et al., 1997; Bolduc et al., 2012)(Supplemental Figure 10).

One of these SNPs resulted in a premature stop codon within Sevir.7 G140700 (+1860 from the transcriptional start site; Figure 3B), which encodes the syntenic ortholog of Dwarf11 (D11) in rice, the cytochrome P450 724B involved in BR biosynthesis (Tanabe et al., 2005; Sakamoto et al., 2006).

Our RNA - seq analyses showed that SvBd1 (Sevir.2 G437800), encoding the ortholog of a conserved AP2 - ERF TF, which specifies SM identity in maize and other grasses (Chuck et al., 2002), was expressed at substantially higher levels in the bsl1 - 1 mutant compared with the wild type, consistent with increased production of spikelets in place of bristles (Table 2).

TDP - 1, the Caenorhabditis elegans ortholog of TDP - 43, limits the accumulation of double - stranded RNA.

In order to expand the analysis of calcification associated genes, the gene expressions of S. pistillata's orthologs of galaxin and galaxin - like were analyzed through semi-quantitative real - time PCR (Figs. 5A — 5B and File S1).

In a 2016 National Institutes of Health summer internship at the National Human Genomic Research Institute, Sappington conducted a third research project in which she demonstrated a fast, alignment - free computational method for identifying orthologs — similar genes from species that are related by descent from a common ancestor.

The evidence of ortholog genes expression which likely associated with Smad proteins, Wnt, TGF - β signaling pathways, and cartilage formation in S. pistillata supports previous reports suggesting that gene regulatory pathways of development and biomineralization processes across the metazoan evolution are considerably conserved (Jackson et al., 2007; Marin et al., 2008).

Bumble bees possess a similar detoxification system thanks to a CYP9Q3 ortholog that the team has named CYP9Q4.

As expected, an ortholog of AtDwf4 and OsDwf4 in S. viridis (SvDwf4; Sevir.9 G483600) was identified.

In addition, one of the genes identified — an ortholog of human COL2A1 is commonly used as a chondrocytic maker in the development of cartilage (Zaucke et al., 2001).

Jason Heaney, Baylor College of Medicine - Modelling human disease variants in murine ortholog (s) with CRISPR / Cas9

The ortholog of the rice ebisu dwarf2 gene, which encodes CYP90D2 (SvROT3 / CYP90C1; Sevir.5 G137200), a P450 that catalyzes C - 23 hydroxylation of BRs (Sakamoto et al., 2012), was significantly upregulated in the bsl1 - 1 mutant.

Among the genes that were identified to be up - regulated are orthologs that encode for human collagen proteins: ADAMTS2, ADAMTS7 and COL2A1.

Whereas 12 of 16 annotations were confirmed by RT - PCR in human tissues, for only seven genes mouse orthologs could be identified and found to be expressed.

Instead, they discovered that each V. carteri cell type expresses orthologs of genes from different temporal phases of the light — dark cycle in a related unicellular alga, Chlamydomonas reinhardtii, with somatic cells enriched for expression of dark - phase genes, and gonidial cells enriched for expression of light - phase genes.

cell type expresses orthologs of genes from different temporal phases of the light — dark cycle in a related unicellular alga,

Characterization of the Drosophila ortholog of the human Usher Syndrome type 1G protein sans.

Ward N, Moreno - Hagelsieb G. Quickly finding orthologs as reciprocal best hits with BLAT, LAST, and UBLAST: How much do we miss?.

Abbreviations: AL3E, after L3 ecdysis; FoxO, Forkhead Box O; FRE, FoxO - Response Element; GBP, Growth - Blocking Peptide; GFP, green fluorescent protein; IIS, insulin / insulin - like growth factor signaling; ILP, insulin - like peptide; L3, third larval instar; pAKT, phosphorylated AKT; ppl, pumpless; qPCR, quantitative PCR; Rheb, Ras homolog enriched in brain ortholog; TOR, Target of Rapamycin

For each Nasonia gene with a RBH ortholog in D. melanogaster, we assigned the immune function annotated for D. melanogaster, based on previously published lists of immune genes in Drosophila [5].

Benchmarking Universal Single - Copy Orthologs (BUSCO) analysis showed that the pipeline was able to identify at least 95 % of BUSCO.s plantae dataset.

Identification of likely orthologs of tobacco salicylic acid - binding protein 2 and their role in systemic acquired resistance in Arabidopsis thaliana

The structure of YqeH: An AtNOS1 / AtNOA1 ortholog that couples gtp hydrolysis to molecular recognition

BioGPS presents data in an ortholog - centric format, which allows users to display mouse plugins next to human ones.

TCF class is a classification of human transcription factors (TFs) and their mouse orthologs based on the characteristics of their DNA - binding domains.

Such similar global, spermatogenic - specific impacts of mutations in orthologs in divergent phyla is surprising and unprecedented, given the vastly different organization of testicular structure, type of spermatogenesis and differences in the contribution of hormonal control in mammals and insects.