Sentences with phrase «necroptosis in»
248/3: 30 Necroptosis in Niemann - Pick Disease, type C1: A potential therapeutic target.
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Receptor interacting protein kinase 1 (RIPK1) has important kinase - dependent and kinase - independent scaffolding functions that activate or prevent apoptosis or necroptosis in a cell context — dependent manner.
Not exact matches
The Max Planck researchers then showed that less necroptosis of endothelial cells and less metastasis occur in genetically modified animals in which Death Receptor 6 is disabled.
This process, known as necroptosis, enabled cancer cells to overcome an endothelial cell layer in the laboratory.
These data reveal that the tissue damage present in this SIRS model is reflected, in part, by breaks in the vasculature due to endothelial cell necroptosis and thereby predict that RIPK1 kinase inhibitors may provide clinical benefit to shock and / or sepsis patients.
There, in a quest to develop targeted therapies for ovarian cancer, she began studying necroptosis, a form of programmed cell death.
Differential roles of RIPK1 and RIPK3 in TNF - induced necroptosis and chemotherapeutic agent - induced cell death
Recently, RIPK3 was demonstrated to require a Bax / Bak effect on the mitochondrial permeability transition pore to carry out necroptosis, and the importance of both RIPK1 and RIPK3 in relation to necroptosis - directed degenerative, inflammatory, and infectious diseases has been published (Moriwaki et al., 2015).