Sentences with phrase «neural stem cell studies»

In the lab for Human Brain and Neural Stem Cell Studies we aim at developing experimental paradigms to systematically identify novel types of neural stem and progenitor cells that serve as building blocks for brain development.

Not exact matches

«We have confirmed what earlier studies indicated, and gained new knowledge about molecular characteristics of these neural stem cells,» says Milos Pekny, professor at the Institute of Neuroscience and Physiology.

«It's very difficult to study neural stem cells in their complex natural environment,» Xie said.

We believe that they will also lead to the development of a whole new range of therapies for neurodegenerative diseases of the central nervous system,» explains corresponding author of the study Jihwan Song, professor and director of Neural Regeneration and Therapy Group at the CHA Stem Cell Institute of CHA University.

In a separate but related study, scientists this week also announced that they successfully reversed Parkinson - like symptoms in several monkeys by transplanting human neural stem cells into their brains.

The possibility that they might be important in nerve cell development intrigued neuroscientists Fred Gage and Tomoko Kuwabara of the Salk Institute in La Jolla, California, and colleagues, who were studying how adult neural stem cells differentiate.

In a new study published in Science, the laboratory of Sebastian Jessberger, professor in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampus.

The study, which was led by postdoc Gregor Pilz and PhD student Sara Bottes, used in vivo 2 - photon imaging and genetic labeling of neural stem cells in order to observe stem cell divisions as they happened, and to follow the maturation of new nerve cells for up to two months.

«Our study suggests that if a cancer - causing mutation occurs in the neural stem cell population in the SVZ, it gives rise to the proneural or the neural glioblastoma subtype.

The approach enabled a wide range of studies of human brain development, including implicating a new class of neural stem cell recently discovered by the lab in the evolutionary expansion of the human brain and identifying how the mosquito - borne Zika virus may contribute to microcephaly in infants infected in utero.

«Neural stem cell divisions appear to be much more asymmetric than we had previously anticipated,» states Darcie Moore, postdoc in the group of Sebastian Jessberger and lead author of the study.

Neurobiologist Marta Florio and her team made the discovery while studying a type of neural stem cell that forms neurons when embryos develop.

tumors from neural stem cells also contained more glioblastoma stem cells, cells that are believed to give rise to tumor recurrence after therapy,» says Lene Uhrbom, senior lecturer at the Department of Immunology, Genetics and Pathology and lead author of the study.

A study published today in Science shows that the Zika virus hijacks a human protein called Musashi - 1 (MSI1) to allow it to replicate in, and kill, neural stem cells.

Researchers from the University of Cambridge studied a variety of cell lines, including human neural stem cells, to investigate how Zika virus infection can lead to microcephaly.

Evidence from this study suggests Group 4 tumors begin in neural stem cells that are born in a region of the developing cerebellum called the upper rhomic lip.

In studies of neural development in mice, Stahl found that TRNP1 produces a protein that determines whether neural stem cells self - replicate, leading to a balloonlike expansion of cortical surface area, or whether they differentiate into a plethora of intermediate stem cell types and neurons, thickening the cortex and forming more complex brain structures.

Expanding from their previous studies with mice, the researchers first established that under specific conditions, culturing human embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location of the cerebellum — within three weeks, and the expression of markers for the cerebellar plate neuroepithelium — the part of the developing nervous system specific for the cerebellum — within five.

Asst Prof Li, from the Neural Stem Cells Laboratory at NNI, added, «This important study suggests a link between a key neurological disease gene and regulation of microRNAs in the brain.

Lastly, two sessions dedicated to disease modeling and cell therapy, respectively, will highlight ongoing attempts to study and treat diseases using stem cells from the hematopoietic and neural systems.

«From skin to brain: Stem cells without genetic modification: Study yields neural crest cells from adult skin cells, and could lead to new treatments for Parkinson's and other brain illnesses.»

In a quickly executed study that reflects the global public health threat posed by Zika, the researchers compared Zika's effect on cells known as cortical neural progenitor cells to two other cell types: induced pluripotent stem cells and immature neurons.

Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.

Here, Anna presents how studies of neural stem cells and neurons derived from iPS cells of patients show faithful mimicking of known disease phenotypes in our cellular models of disease, like Alzheimer's disease, autism, and Down syndrome.

Russell Kern reports on the 6 - month update on the first - in - human clinical study of neural stem cells in patients with Parkinson's disease.

The findings may even have implications for studying glioblastoma, a common brain cancer whose ability to grow, migrate and hack into the brain's blood supply appears to rely on a pattern of gene activity similar to that now identified in these neural stem cells.

Pluripotent stem cellderived somatic stem cells as tool to study the role of microRNAs in early human neural development

Though Diamond's lab has received federal funding, he said researchers who have been cut out include those who study pregnancy, fetal development or neural stem cells.

We will mine and exploit information from studies and screens in model organisms, but our primary focus is on the paradigmatic mammalian stem cell systems - haematopoiesis and epithelia in vivo, and embryonic and neural stem cells in vitro.

The finding is based on studies of mice with altered levels of the growth factor PDGF in neural stem cells, which play a key role in the development of the eye.

New Animal Model, Nanotechnologies and Neuroimaging to Study Interactions and Homing of Human Neural Stem Cells in Stroke.

The team used genetically engineered mice to study the effects of different human apoE variants on the maturation of neural stem cells or progenitor cells, from which new neurons develop in the adult brain.

In this study, we analyzed three different cultures of neural cells carrying trisomy of chromosome 21, which were generated by directed differentiation from induced pluripotent stem cells (iPS cells).

While previous studies had demonstrated a synergistic effect of BMP and LIF on the astrocytic differentiation of human neural stem cells [15], it remains unclear whether BMP and LIF induce distinct types of astrocytes and if so, what the functional properties of these astrocytes may be with respect to repairing CNS injuries.

$ 1.1 million to Dr. Gary Steinberg, a neurologist at Stanford University, to study how human neural or brain nerve stem cells can help people recovering from a stroke.

I have spent many years studying 2q23.1 deletion and duplication syndrome through genotype - phenotype, neural progenitor stem cells, and RNA - seq studies.

10/10/2007 Researchers Reveal Repressor Protein Blocks Neural Stem Cell Development A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Me... MNeural Stem Cell Development A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Me... MorStem Cell Development A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Me... Mneural stem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Me... Morstem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Me... More...

In the second study, authored by Gladstone postdoctoral scholar Mingliang Zhang, PhD, and published in Cell Stem Cell, the scientists created neural stem cells from mouse skin cells using a similar approStem Cell, the scientists created neural stem cells from mouse skin cells using a similar approstem cells from mouse skin cells using a similar approach.

Prior to joining ViaCyte, Dr. D'Amour performed pre-doctoral research with Dr. Fred Gage at The Salk Institute where he studied stem cell plasticity in neural stem cells.

Some of the long term aims of the studies are (i) to contribute to the understanding of the mechanisms that control cortical development and evolution, (ii) to use the knowledge to grow neural stem cell populations of high purity and viability for therapeutic approaches and (iii) to study how neural stem cells can be activated in vivo.

In a study published in February online editions of the journal Developmental Biology, Morgridge scientists tested the stringency of the developmental clock in human stem cells during neural differentiation.

Our initial studies were on characterization of different adult neural stem cell types from murine and human brain and human bone marrow.

And two studies published this summer in Nature Biotechnology found that direct conversion methods to produce neural stem cells that employ the traditional reprogramming genes actually pass the cells through a pluripotent step.

Cortical development and cortical stem cells The laboratory uses neural stem cell culture, transgenic model systems and retroviral vectors to study signalling pathways that are central in mouse cortical development and in particular in cortical stem cells.

The study found that when brain cells were exposed to ar - tumerone, neural stem cells increased in number through enhanced proliferation.