Sentences with phrase «neuronal hyperexcitability»
AMANTADINE This drug acts to modulate the pain response by antagonizing the N - methyl - d - aspartate (NMDA) receptor and the role they play in central neuronal hyperexcitability (wind up).
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The UCI team also uncovered that during seizures, the M - current is suppressed, which contributes to neuronal hyperexcitability.
Not exact matches
Mutations that detrimentally affect the function of neuronal KV7 channels cause hyperexcitability syndromes such as benign familial neonatal seizures, early onset epileptic encephalopathy, and peripheral nerve hyperexcitability.
However, detailed understanding of the molecular basis for the role of neuronal KV7 channels in hyperexcitability syndromes has been lacking.
«If hyperexcitability is the brain network basis for these symptoms, then reducing neuronal excitability with certain drugs that modulate inhibition could be of therapeutic value in these devastating neurodevelopmental disorders.»
Barry G et al. (2017) The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states.