Sentences with phrase «new chemical structures»

The drug company hires chemists to alter the structure of human hormones in the laboratory so the drug company can obtain a patent on the new chemical structure, which is a new drug.

The drug companies hire chemists to alter the structure of human hormones in the laboratory so the drug company can obtain a patent on the new chemical structure, which is a new drug.

Not exact matches

They dreamed up the New York WaterMaker, a machine that can turn any H2O into NYC H2O, with «the exact hardness, molecular structure and chemical composition,» according to the product's website.

With the increase in complexity new entities emerge — the classical world out of the quantum world, molecules and chemical processes out of atomic structures, simple living organisms out of complex molecular structures.

In a new dissipative structure (either a steady state or a limit cycle), concentrations of chemicals and rates of mass - transfer between the system and surroundings will not be those characteristic of the previous equilibrium state (or the nonequilibrium steady state that corresponds to it under conditions of instability) but rather they will be the (perhaps quite different) average values which pertain to the new structure.

The New York WaterMaker is a patent - pending water source replication system that not only functions as a commercial water filter, but also replicates the exact hardness, molecular structure, and chemical composition of a specific location's water, with a key focus on replicating New York City water.

In nature, when a seed is planted, the seed's chemical structure changes in order to support new life.

Understanding molecular structure at a theoretical level is perhaps interesting, but continually producing new chemicals (which we could only identify because the book told us how to) meant almost nothing.

Working with other researchers, he captured the first image of the atomic structure of graphene and synthesized two new chemical derivatives, graphane and fluorographene.

Computer simulations and hands - on displays allow visitors to Marvelous Molecules — The Secret of Life at the New York Hall of Science to peek inside the molecular structure of living things to see how chemicals affect the brain and how DNA passes on genetic traits.

The objective of the research project led by Marko Kallio, Principal Scientist at VTT, was to accelerate the drug development process by identifying new compounds that would possess similar binding properties and cellular phenotype, but a different chemical structure, as the selected drugs in clinical use or investigational compounds in development.

The same method was employed to predict chemical structures of new compounds.

They depleted their reserves of these chemicals rapidly each time a new auditory signal came in, and they decreased the amount of space within the cells that housed sac - like structures called vesicles — biological storage tanks where neurotransmitter chemicals are kept.

Citing how this new technique represents a broad range of chemical structures unlikely to be found using conventional means, Helbling said, «These results are not only interesting from a novelty perspective, but demonstrate the breadth of chemical coverage that our suspect screening affords.»

«The atomic force microscope gives us new information about the chemical bond, which is incredibly useful for understanding how different molecular structures connect up and how you can convert from one shape into another shape,» said Crommie.

In recent years, the have presented important new findings about the structure of metal oxides, about the mobility of atoms on their surface and their chemical properties.

Vivek Vasantha at A * STAR Institute of Chemical and Engineering Sciences — together with scientists from across Singapore under the Innovative Marine Antifouling Solutions (IMAS) program — developed a new block copolymer that can self - assemble into spherical micelle structures in which one monomer forms the core and the other forms the outer shell.

The new findings appear in the Journal of the American Chemical Society and represent an important step toward the development of molecular components for the assembly of nanomachines: For the greater the degree of control available, the more complex are the functions that can be performed by such structures.

For the study, the Bohn worked closely with TSRI chemist Thomas Bannister, PhD, to develope new potential drug molecules; they then tweaked their chemical structures to systematically vary the «bias» between the two pathways — G protein signaling and beta - arrestin recruitment.

What they found was totally new: an unknown crystal structure with a chemical composition similar to perovskite.

This week, a group of researchers unveiled a tool that could help streamline the process: a vast database of safety information that will allow users to compare new chemicals to existing compounds with similar structures, and flag potential risks.

Knowing how the internal and surface structure of a battery material changes over a wide range of chemical compositions will aid future studies on cathode transformations and could also lead to the development of new battery materials.

University of Wisconsin - Madison engineers have developed a new approach to structuring the catalysts used in essential reactions in the chemical and energy fields.

While conventional carbonaceous catalysts have amorphous carbonaceous structures that cause a decline in catalytic activities, the new synthesis route enables the formation of carbonaceous catalysts with controlled chemical structures like organic - based catalysts (Fig. 1b).

We can discover new chemical reactions and make bespoke chemical structures by playing with the conditions of the TEM — for instance the energy of the electron beam.

In the newest installment of the movie series, 2006's Superman Returns, super-villain Lex Luthor reveals the mineral's made - up chemical formula to be sodium lithium boron silicate hydroxide, but geologists unearthed something with that very structure in Serbia in 2007.

But, the computer only generates sequences for brand new protein recipes; the molecules then need to be folded into a three - dimensional structure to function, whether it's helping cells recognize chemicals, driving chemical reactions or the myriad other functions that proteins perform in the natural world.

«For 20 years we have been using rational bioengineering to modify the chemical structures of clinically important natural products — using genetics to make a new molecule in a process that parallels medicinal chemistry — and that's what we were doing when we stumbled upon this,» said Professor Barrie Wilkinson from the John Innes Centre.

Martin Lercher of the University of Bath in England and his colleagues studied a benign strain of Escherichia coli to see how the common intestine dweller picked up new parts for its metabolic network — the internal system of chemical reactions that produce the necessities of life, such as amino acids or cellular structures.

Researchers from Boston College and Harvard have created an elusive honeycomb - structured material capable of frustrating the magnetic properties within it in order to produce a chemical entity known as «spin liquid,» long theorized as a gateway to the free - flowing properties of quantum computing, according to a new report in the Journal of the American Chemical chemical entity known as «spin liquid,» long theorized as a gateway to the free - flowing properties of quantum computing, according to a new report in the Journal of the American Chemical Chemical Society.

A team led by Fengzhi Li, PhD, of Roswell Park Cancer Institute has reported significant new findings regarding the chemical structure of the novel anticancer agent FL118.

Although carbon has been subjected to far more study than all other elements put together, the buckminsterfullerene hollow - cage structure, recently proposed to account for the exceptional stability of the C60 cluster, has shed a totally new and revealing light on several important aspects of carbon's chemical and physical properties that were quite unsuspected and others that were not previously well understood.

They offer a new way to observe minute structures and to perform chemical analysis

«This new constraint on plume structure has important implications for how deep mantle material is entrained in plumes, and it gives us the clearest picture yet for the chemical structure of an upwelling mantle plume.»

While conventional carbonaceous catalysts have amorphous carbonaceous structures that cause a decline in catalytic activities (Fig. 1a), the new synthesis route enables the formation of carbonaceous catalysts with controlled chemical structures like organic - based catalysts (Fig. 1b).

Indiana University researchers have reported the first definitive evidence for a chemical bond between two negatively charged molecules of bisulfate, or HSO4, a new molecular structure with potential applications to the safe storage of nuclear waste and reduction of chemicals that contaminate water and trigger large fish kills.

The team finds that the mineral disassociates into two phases one a magnesium silicate perovskite missing iron, which is represented by the Fe portion of the chemical formula, and a new mineral, that is iron - rich and hexagonal in structure, called the H - phase.

New theoretical approaches provide insights into chemical bonding and structure from biology to materials

Our laboratory will focus on applying new synthetic and chemical biology methods to understand chromatin structure and function.

The samples ranged from a simple alcohol to a complex plant hormone, and the new method, dubbed «CAL» for covalent alignment (the molecules form a type of chemical bond known as a covalent bond in the MOFs), enables researchers to determine the complete structure of a molecule from a single MOF crystal that contains the sample molecules in its pores.

The main objective of the Institute conducted fundamental research - to obtain new data on the structure and transformations of organic compounds, their mechanism of chemical reactions, the synthesis of organic compounds, new classes, new opening reactions, the development of new catalysts and to investigate the relationship of their structure to the catalytic activity.

Fellow, American Association for the Advancement of Science, Chemistry Division, for innovations in synchrotron radiation spectroscopy research in revealing electronic and atomic structure of new materials; and strategic leadership in the field of chemical imaging, 2015

University of Wisconsin — Madison engineers have developed a new approach to structuring the catalysts used in essential reactions in the chemical and energy fields.

While the finding will provide a new angle for scientists to study the chemical composition and structure of rocky planets, the possibility that life may have contributed to the inferred mineralogy certainly intrigued the team.

MS / MS refers to a newer technique called tandem mass spectrometry, an even more powerful method of determining chemical structures.

They form molecular species that activate the carbon dioxide making it easier to convert, and create new, nonuniform solvent structures that can act as nanoscale reactors to promote chemical reactions.

In addition to extending a relatively new method of determining the chemical composition of planets to examine their internal structure, the team found that the rocky material being accreted by the star could be comprised of minerals that are typically associated with marine life processes here on Earth.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) traStructure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) trastructure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) trastructure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) traStructure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) traStructure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) trastructure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Understanding the chemical reactions that can create tiny molecular cages that hold other «guest» molecules — structures called clathrates — is key to creating a new generation of electronic devices and possible energy materials.

These «molecular engineers» try to understand and harness the principles of self - organization to generate new biological structures endowed with the most typical features of biological matter, the ability to harness energy to do mechanical or chemical work.