Sentences with phrase «new gene drive»

New gene drive approaches will be necessary to overcome the challenge posed by resistance, especially in genetically diverse, natural populations.

Not exact matches

Collectively, this new kind of startup can help drive down the cost of gene therapy discovery for patients.

«The services segment will grow between 13 per cent and 20 per cent per year over the next five years driven by continued growth in existing services along with new, innovative services,» Gene Munster, co-founder of Loup Ventures and a veteran Apple analyst, wrote in an email following the results on Tuesday.

Marshall points out that the relatively fast appearance of new animal species in this period is not driven by new genes, but rather by evolving from existing genes through «rewiring» of the gene regulatory networks (GRNs).

In the Dec. 9 SN: Lessons from the Pliocene, searching for new ways to fight MS, a supernova on repeat, the great gene drive debate, spider sleep secrets, an ailing boy gets new skin, kleptopredation and more.

SO CUTE, SO WRONG No one has a genetic way of getting rid of invasive brushtail possums (shown) in New Zealand, but now is the time to debate whether CRISPR gene drives are too strong to be considered, two researchers argue.

Standard forms of CRISPR gene drives, as the tools are called, can make tweaked DNA race through a population so easily that a small number of stray animals or plants could spread it to new territory, predicts a...

The major concern is that current gene drives «are probably too powerful for us to seriously consider deploying in conservation,» says geneticist Neil Gemmell of the University of Otago in Dunedin, New Zealand.

Standard forms of CRISPR gene drives, as the tools are called, can make tweaked DNA race through a population so easily that a small number of stray animals or plants could spread it to new territory, predicts a computer simulation released November 16 at bioRxiv.org.

In addition to DARPA environmentalists, biosafety experts and leading gene drive researchers say a new approach to mitigation and control is needed for the technology to advance safely.

CRISPR / Cas9 gene drives, as the new tools are called, are molecular cut - and - paste machines that can break regular rules of inheritance and get passed to more than 50 percent of offspring (SN: 12/12/15, p. 16).

«This was all forest» Gene - Rene Vaceus, a driver for the United Nations who returned to his native Haiti from New York a few years ago to retire, drives past the barren hills and says the verdant country of his youth is long gone.

Now, new research suggests changes at the epigenetic level — specifically alterations in proteins that affect gene expression, rather than genetic mutations — could be driving childhood ependymomas.

These new drives insert genes that produce the components of the system: a cutting enzyme and an RNA to guide it to the proper cutting site.

The JASONs» gene - drive discussion involved around 20 scientists, according to Philipp Messer, a population geneticist at Cornell University in Ithaca, New York, who attended the meeting.

But at a meeting in June, the secretive group took stock of a new threat: gene drives, a genetic - engineering technology that can swiftly spread modifications through entire populations and could help vanquish malaria - spreading mosquitoes.

Hence the term gene drive for this prospective new weapon in pest control.

For example, genetically engineered organisms used in the research laboratory to develop new chemical synthesis methods are not likely to require the same level of public dialogue as products that have more uncertainty associated with them, such as organisms with gene drives, which enhance organisms» ability to pass certain genetic traits on to their offspring.

In researching and assessing potential new strategies, Campbell and his colleagues have made an argument for the use of gene drives on islands.

This new gene expression data therefore provides additional evidence that the altered behavior of bacteria in space results from decreased gravity driving reduced extracellular transport of molecules.

New strategies to control mosquitoes are being developed that use «gene drive» - using the latest Crispr / Cas 9 genetic tools to make mosquitoes infertile or unable to carry the malaria parasite.

New research suggests that fluid driven by tiny swirling hairs called cilia may activate certain genes in the growing embryo that lay the groundwork for this asymmetry.

Tina Hesman Saey discussed the power of a new gene - editing technique to boost the development of gene drives in «Gene drives unleashed» (SN: 12/12/15, p. gene - editing technique to boost the development of gene drives in «Gene drives unleashed» (SN: 12/12/15, p. gene drives in «Gene drives unleashed» (SN: 12/12/15, p. Gene drives unleashed» (SN: 12/12/15, p. 16).

Gene drive is so different from other technologies involving genetic modification that it requires a whole new way of thinking about how to evaluate and regulate it, says Jennifer Kuzma, a natural and social scientist at North Carolina State University (NCSU) in Raleigh who helped organize a February workshop there.

«The bugs are somehow driving gene expression in the host through alteration of the epigenome,» explains John Denu, a UW - Madison professor of biomolecular chemistry and a senior researcher at the Wisconsin Institute for Discovery, and a co-author of the new study.

Until recently, biologists had thought that different genes drove each instance of echolocation and that the relevant proteins could change in innumerable ways to take on new functions.

«This is a completely new way of transmitting genes,» Raoult says, and it could be driving evolution of new species in as - yet - unknown ways.

The best way to ensure that the genetically modified mosquitoes become the dominant type is for researchers to add something known as a «gene drive» to the new mosquitoes.

«New tools will drive greater understanding of wheat genes: Vast genetic resource will aid development of wheat plants with improved traits.»

Using bioinformatics tools to identify and map out specific components and regulatory interconnections, the study team found highly dynamic activities during CD8 + T cell responses: a distinct repertoire of super enhancers — groups of enhancers that interact with promoters to drive gene transcription, new groups of enhancers that jump into activity only in the memory cell stage, and extensive re-wiring of regulatory circuits from one cell stage to another.

For instance, while I was flattered to find him quote one of my own review papers (2)-- although the quote is actually a chimera drawn from two very different parts of my review — he fails to even mention the review's (and many other papers») central point: that new genes did not drive the Cambrian explosion.

With the advent of new, more efficient, and targeted gene - editing techniques such as CRISPR / Cas9, gene modifications can, in principle, be spread throughout a population of living organisms intentionally and quickly via a gene drive, circumventing traditional rules of inheritance and greatly increasing the odds that an altered gene spreads throughout a population.

TCGA has verified known cancer genes and found new genetic changes driving some cancers; although the project has been criticized as too costly, many researchers think it has been worthwhile.

«We suspect that one of the primary factors that drives the sharing of antibiotic resistance genes is exposure to new antibiotics,» Dantas said.

They are driven by stem cells with the proneural pattern of gene expression and depend on rapid cell division and angiogenesis — creation of new blood vessels.

«Engineered gene drives and the future: Entomologists review pros, cons and regulatory issues surrounding new technology that could help halt the spread of diseases such as Zika virus, dengue fever and malaria.»

«The bugs are somehow driving gene expression in the host through alteration of the epigenome,» explains John Denu, a UW — Madison professor of biomolecular chemistry and a senior researcher at the Wisconsin Institute for Discovery, and a co-author of the new study.

New results show that these patients also do better regardless of their age, stage of disease and whether or not they have a cancer - driving mutation in the BRAF gene.

And if an introduced gene had unexpected consequences, researchers might reverse a gene drive by introducing more wild, unmodified individuals to outnumber the new ones.

Gene drives could have widespread uses, potentially leading to new ways of combating malaria and other insect - borne diseases and controlling invasive species.

And that's key at a time when an increasing number of researchers are invested in understanding how genes work, how they affect our health, and how they can drive new treatment options.

Our meetings examined the variety of new genetic techniques developed to cure human malaria and Zika virus by eliminating mosquitos — such as Oxitec's sterile males, wolbachia applications, and gene drives — and looked at how they might be applied to protect Hawaiian birds.

The new technology, known as a gene drive, is genetic engineering on an entirely new scale: It makes it possible not just to modify organisms in the laboratory, but to edit the genes of entire populations in the wild.

There will be a rush of new research and development to pull in the most plausible candidate genes: competition will drive this process, because specific genetic alterations will quickly become standardized, commoditized, widely cross-licensed products.

New gene editing tools are making it possible to harness a natural process for humane and superiorly effective eradication of non-native pests: the gene drive.

Edits and transgenes could mutate during or after the spread to fixation, though subsequent gene drive releases could periodically overwrite the mutated versions with a new copy.

RNA - guided gene drives can theoretically be used to delete any existing gene, to edit any gene important for fitness, or to add new transgenes.

Test each mutant mouse line (4,000 mouse lines in the first 5 years, and ultimately up to 20,000) through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human diseases.Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems.

Armed with knowledge of which mistakes in genes are driving which cancers, doctors and scientists will be able to maximise the chances of cure for each patient by picking the best treatments and by developing new and more targeted treatments for people with oesophageal and prostate cancers in the future.

A New Twist in Breast Cancer Working with mice, scientists have shown that a protein made by a gene called TWIST may be the proverbial red flag that can accurately distinguish cells that drive aggressive, metastatic breast cancer from other breast cancer cells.