New genetic data and new methods of analysis are finally allowing us to approach these questions.
To address IBD, Jansson's team has collaborated with bioinformaticians to integrate overwhelming amounts of
new genetic data, and has published studies comparing healthy microbiomes to those in IBD patients - all with the aim of future diagnostics and potential new therapies, she said.
The new genetic data and analysis bolsters a theory that has long been held by archaeologists, although they had little evidence to support it until now.
Tsutsui himself hopes to use
the new genetic data to identify how the Argentines use chemicals to lay down trails for fellow ants to follow.
The new genetic data support a recent hypothesis about why domesticated animals often have a juvenile appearance.
The new genetic data now confirm suspicions that there are further connections to other characteristics and illnesses.
Not exact matches
In contrast, the
new study made use of wrist accelerometer
data, which is more objective and quantifiable, and a large
genetic dataset from about 85,000 UK Biobank participants aged 40 to 70.
The team combined the
new fossil evidence with previously collected
genetic data from living birds to update the phylogenetic tree of bird evolution.
They also re-examined real GWAS
data to find promising
new candidates for
genetic interactions that affect bipolar disorder, coronary artery disease, Crohn's disease, and rheumatoid arthritis.
The
new framework enhances the ability to detect
genetic associations and interactions by taking advantage of
data from other genomic studies of the same population.
«Our
new data is scientifically important because ataluren restores activity to genes inactivated by nonsense mutations, and as a result, it has the potential to do so much for a large number of very complex
genetic disorders,» Jacobson said.
In a
new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological,
genetic, physiological and anatomical
data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.
Unlike «big
data»
genetic studies, which have loosely linked hundreds of
genetic changes to schizophrenia but can not explain varying symptoms, the
new study revealed distinct disease versions that may affect large slices of patients and enable precision treatment design, say the authors.
They charted how fluctuating oxygen concentrations correlated with the emergence of
new animals as seen in the fossil record and from
genetic data.
While the
new models — some of which are being developed in the Stadler group — are more complex and require a lot more computation, they provide more accurate results even at the start of an epidemic, when very little
genetic data is available.
«The
genetic [
data] are pretty convincing,» says grape geneticist Bruce Reisch of the
New York Agricultural Experiment Station in Geneva.
In addition to his position at MyHeritage, a company that allows consumers to discover their family history through
genetic tests and its genealogy platform, Erlich is a computer science professor at Columbia Engineering, a member of Columbia's
Data Science Institute, and an adjunct core member of the
New York Genome Center (NYGC).
A
new study in the journal Genetics in Medicine, published by Springer Nature, now shows that up to 40 percent of direct - to - consumer (DTC)
genetic tests provide incorrect readings in the raw
data.
Much of the
data in the study has come out previously, some in earlier papers about the parents of the virus that «reassorted» to make this
new H1N1, some in the flood of
genetic sequences put into public databases, and some in press interviews with public health agencies and academic investigators.
The
new data promise to improve our understanding of many common diseases that might have similar
genetic underpinnings.
Collins, who points out that the commitment of the genome project to address ethical issues as well as generate
data came at the project's inception, describes four categories of questions: Fairness and privacy; implementation of
new medical practices based on genomic
data (e.g.,
genetic testing); use of human subjects; and public education.
In the
new work, researchers looked at
genetic and health
data on more than 100,000 individuals from previous large studies to determine whether
genetic alterations that are associated with vitamin D levels predispose people to asthma, dermatitis, or high IgE levels.
«
New data reveal extent of
genetic overlap between major mental disorders.»
Now, a
new study that included
genetic data from more than 190,000 people has identified two genes that, when altered in specific ways, either promote or undermine cardiovascular health.
In the
new study, they used the same genome - wide information and the largest
data sets currently available to estimate the risk for the illnesses attributable to any of hundreds of thousands of sites of common variability in the
genetic code across chromosomes.
Vucetich and Peterson have analyzed
data from decades of scientists» field notes, trying to determine whether the Isle Royale wolves might have benefited from infusions of
new genetic material from wolves crossing ice bridges on other occasions in the past.
A study of
genetic data from 36,000 people with autoimmune diseases shows that dialing down a protein's activity — but not knocking it completely out — may provide a
new way to calm overactive immune systems without raising the risk of getting infections.
«Our work expands the repertoire of functional
genetic elements,» says the study's leader Yaniv Erlich, who is an assistant professor of computer science at Columbia Engineering, a member of Columbia's
Data Science Institute, and a core member of the
New York Genome Center.
Such a large pool of patient
data would greatly facilitate research on ALTS and open
new avenues of study into
genetic aspects of other forms of laryngotracheal stenosis.
Beth Shapiro, a paleogenomics researcher at the University of California, Santa Cruz, who also studies the passenger pigeon's
genetic past, says the
new data are encouraging and fit with her own group's unpublished findings.
The convergence of several factors explains the trend: cheaper
genetic sequencing technologies, the discovery of
new oncogenes (genes that can cause a normal cell to become cancerous), a
new generation of computers and bioinformatics that can analyze vast amounts of
data, and a multibillion - dollar effort by researchers inside and outside the pharma industry to develop targeted drugs and companion diagnostics for cancer.
Astroviruses are not usually deadly, but the
new data suggest that they are less discriminating with regard to what they infect than researchers had thought, raising the possibility that different strains could trade
genetic material in monkey hosts and give rise to
new forms that might cause more serious disease in people.
Harvey and colleagues compiled and analyzed an unprecedented
data set containing
genetic sequences from 17,000 individuals in 173
New World bird species, ranging from ducks and owls to swallows and sparrows.
Instead, NIMH is working on a long - term plan to develop
new diagnostic criteria and treatments based on
genetic, physiologic, and cognitive
data rather than symptoms alone.
Studies of the modern species» blood - feeding physiology got a solid source of
new data in 2013 when an international team decoded the
genetic instruction book of the sea lamprey, a notorious invader of the Great Lakes.
The
new genetic tree uses an enormous amount of
data to refute the notion that turtles are most closely related to lizards and snakes.
A $ 1.7 million drug discovery effort to identify molecular and
genetic risk factors and
new therapeutic targets for cognitive decline and Alzheimer's disease, based on
data from the Religious Order Study and the Rush Memory and Aging Project.
«We got these
data right around
New Year's 2009,» Sabunciyan said one day last August as he scrolled through a file containing 2 billion letters of
genetic code, equivalent to 2,000 John Grisham novels composed just of the letters G, A, T, and C (making the plot a great deal more confusing).
«These
data suggest that the interplay between race and ethnicity as social constructs and
genetic ancestry as a biological construct is more complex than we had realized,» said Noah Zaitlen, PhD, a UCSF assistant professor of medicine and co-senior author on the
new study.
But when we put these
genetic associations alongside the ENCODE
data, we saw that although the loci are not close to a protein - coding gene, they really are close to one of these
new elements that we're discovering.
Varun Warrier added: «We now need to confirm these results using
new genetic and brain scan
data so as to understand how exactly gene activity and thickness of the cortex are linked in autism.»
By combining
genetic data, ancestry information, and electronic health records, scientists are able to identify neighborhood - level patterns of migration in the
New York City area, according to research presented at the American Society of Human Genetics (ASHG) 2015 Annual Meeting in Baltimore.
In addition, based on the
genetic data, they were able to evaluate morphological characters for each species and created a completely
new key for identification.
Moreover, the
genetic data led to the discovery of a
new species, represented by a single specimen from the High Atlas Mountains in Morocco.
BETHESDA, MD — By combining
genetic data, ancestry information, and electronic health records, scientists are able to identify neighborhood - level patterns of migration in the
New York City area, according to research presented at the American Society of Human Genetics (ASHG) 2015 Annual Meeting in Baltimore.
Her research has led to a gene library for researchers around the world, where they can mine archived
genetic data for
new insights into alcoholism and addiction research.
PROVIDENCE, R.I. [Brown University]-- Researchers from Brown University have developed a
new method for sifting through genomic
data in search of
genetic variants that have helped populations adapt to their environments.
The Broad Cancer Dependency Map team adds CRISPR - based
data from 342 cancer cell lines to their growing catalog of
genetic dependencies in cancer, and a
new method for ensuring that
data's accuracy.
Patrick Bellgowan, Ph.D., a program director at the National Institute of Neurological Disorders and Stroke at NIH, says the study is a clear demonstration of how the open science approach to
data can help generate
new hypotheses about brain disorders: «Through
data sharing and collaboration, ENIGMA is working to uncover important common and distinguishing neurobiological and
genetic features of psychiatric and neurological disorders.»
The challenge for the years to come is to convert
data on
new genes, gene defects and human genome variation in patients with
genetic cardiovascular disease into functionally relevant information on the diverse pathophysiological mechanisms and clinical manifestations.