Sentences with phrase «new mode of action»

This is a new mode of action and might be a starting point for novel tuberculosis therapies.

«New mode of action for HUMIRA in rheumatoid arthritis patients.»

What Christ brought to man was not a new code - book of detailed regulations, but a new orientation and attitude from which new modes of action flow.

This indicates that the innovation potential has been substantial for fungicides with new modes of action and excellent performance, not least because some of the older groups have suffered from an erosion of efficacy against some important pathogens due to the emergence of resistance [see also FRAC 2007 (1)-RSB-.

What we can do is deliver new medicines with new modes of action and safeguard the longevity of the anti-malarial through use in combination as long as possible.»

Coogler stages the film's obligatory globe - trotting action setpieces with vigor; an extended, multi-pronged battle through Busan fuses the great movie car chases of yore with a handful of tech - fueled treats, sending old and new modes of action careening through the neon - lit sreets at a breathless clip.

Not exact matches

It should not be denied that the new ecumenical formula is action - oriented and tends towards activism as the main mode of doing mission.

Whatever its mode of action, Zyban clearly works, as Hurt and his colleagues demonstrated in a paper published in the October 23 issue of the New England Journal of Medicine.

«Mensacarcin's unique mode of action indicates it might represent a promising lead for the development of new anticancer drugs.»

In tests, they found that the new compounds have three modes of action.

The paper said resistance to treatment regimens still posed a threat and highlighted the importance of developing treatments containing new chemical classes with different modes of action.

Researchers at the University of Basel's Biozentrum have now gained new insights into the construction, mode of action and recycling of this weapon.

«The capacity to regulate an opioid receptor by means of light will make it possible to obtain new insights into the mode of action of this eminently important class of receptors, and could offer a route to novel treatments of chronic pain syndromes,» he adds.

The next step for the researchers will be to decipher the mode of action of the 100 new chromatin factors.

Professor Bruce added: «This is an important additional finding as it is an increasing concern that although herbicide resistance has been increasing steadily since the 1970s, no new herbicide mode of action has been commercialized since the 1980s.»

Gauri's work focuses on identifying new drug targets against tuberculosis and understanding the mode of action against such targets.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Even if there are no vehicles in this DLC, the four maps are well designed (a couple of them have an interesting «levolution») and the new game mode pushes the player to coordinate their actions.

Vehicle Tag — Once you're done taking down the Freaks and the Cell, join your friends for a new multiplayer mode where up to eight Agents can compete in these six arenas: Speed is the Quay, Industrial Action, Maim Street, Skid Row, Beachhead and The Sum of Human Knowledge.

The fast - paced action and epic boss battles will present fans with a unique vantage point of the earliest days of Ys and the new speedrun mode will allow players to share their results on Xbox Live leaderboards to compete for the fastest Ys Origin player in the world.

The game also has two different modes: Situation mode is a retelling of Mobile Suit Gundam stories with interlaced action, while Mission mode lets players complete new and original missions using their own custom team of three mobile suits.

TimeGate Studios has announced the free release of Skirmish, a brand new action packed game mode for Section 8: Prejudice.

The PS Vita rhythm game launches in Japan on the 24th of March and includes a new Live Quest mode that you can see in action below.

• The Future of Online Multiplayer Action — The game is entirely multiplayer, in a new experience that combines fast - paced online action with the heroic set piece moments traditionally found in campaignAction — The game is entirely multiplayer, in a new experience that combines fast - paced online action with the heroic set piece moments traditionally found in campaignaction with the heroic set piece moments traditionally found in campaign mode.

There are no Overtime or Nightmare modes included, just a bunch of action setpieces that can be burned through quickly, especially during New Game + with a maxed - out Frank.

-- Overall features of AOKP, CM10 and PARANOID ---- Custom JellyBam Settings with preferences ---- Tons of customizations ---- GAPPS Included ---- Hacked youtube with 720p playback ---- Bravia Engine ---- Awesome audio Mods ---- XLoud sound mods ---- Themes and Mods in JellyBam style ---- Latest CM10 / AOKP Kernel compiled from sources ---- New Mali driver ---- Exynos HWComposer ---- Lockscreen with x8 Custom app targets ---- New optimus 4x circle lockscreen ---- Ability to customize color and alpha of the optimus lockscreen ---- Bravia Engine libraries ---- Bravia XLoud audio libraries ---- Paranoid Android settings ---- Per - App - DPI Changer ---- Per - App - Color ---- Custom home action and hardware button in lockscreen ---- Quick / Long click on weather and clock actions ---- JellyBam Panel in settings app ---- AOKP and CyanogenMod Settings ---- Mass storage mode ---- Apollo Music Player (Themed)---- Quick SMS ---- Init.d scripts ---- JellyBOOM script ---- Media quality tweak ---- 3G and GPS Tweak ---- RAM Optimization + Multitasking ---- SmoothScrolling tweak ---- V6 Supercharger included ---- Trebuchet Launcher ---- Touchwiz Launcher with samsung weather widget ---- JellyBam custom Bootanimation by metallaxis ---- Center Clock / No clock / Right Clock ---- Volume Panel (Volume Rocker allows you to change ALL volume levels in one Menu)---- Lockscreen Weather ---- Lockscreen Vibration on / off toggle ---- Performance / Color Settings ---- Brightness Control Slider ---- Multilang ---- JellyBam Style --

And a new «sports mode,» among others, meant for capturing live - action shots, helps BlackBerry users capture a wider variety of images in better quality.

Well, you're going to be getting fun, fast paced, competitive action for up to four players from the Puyo Puyo and Tetris worlds that we all know and love along with a variety of new modes.

This fabulous new remake will also provide substantial multiplayer content, with 8 modes of face - melting action for up to 14 players.

Assemble your dream team — Pick freely from characters from BLAZBLUE, UNDER NIGHT IN - BIRTH, PERSONA 4 ARENA, and RWBY Tactical tag team action — Swap your characters in real time mid-battle for new combos and strategies Simplified controls — High - level gameplay has never been more in reach with standardized input - friendly attack commands for ease - of - use Unique story episodes — Experience the story in Episode mode, with different episodes for BLAZBLUE, UNDER NIGHT IN - BIRTH, PERSONA 4 ARENA, and RWBY Take the fight worldwide — A new and improved online mode offers the best online multiplayer experience yet Go from baby steps to bustin» heads — Arc System Works» trademark top - of - the - line tutorial teaches you the ins - and - outs of battle in no time

The new maps in Judgment are fantastic and the modes offer up the same degree of insane Gears action that fans know and love.

caRRage reached the # 2 position in the Top Free Apps list of App Store Russia in December 2015, was featured by Apple on AppStore front page in June 2016 (it has happened thanks to the football mode «Trashball» for Euro - 2016) and also appeared in many futured lists such as Crazy Corses, Greatest Party Games, New Games We Love, dressed UP for Halloween, Best New Updates, Most Intense Action Games in tens of countries worldwide.

KEY FEATURES — Stunning hand - painted artwork — Critically - acclaimed original music score — Hours of reactive narration deliver a deep story — Intuitive touch controls created exclusively for iOS — Universal App runs on iPad, iPhone, and iPod touch — Variable difficulty for players of all skill levels — Action - packed combat rewards playing with finesse — 10 + unique upgradeable weapons to be used — 6 powerful Bastion structures to be discovered — «New Game Plus» mode unlocked after finishing the story — Game Center achievements and leaderboards — Sync saved data seamlessly via iCloud

NBA Playgrounds 2 raises the intensity of the series» over-the-top, two - on - two street action with a new line - up of online and local multiplayer game modes, as well as new courts from playgrounds across the world.

The PS ® Vita version, which is adapted for the handheld experience by Armature Studio, takes the fighting action of Injustice: Gods Among Us on the go, with new touch controls for mini-games in the story mode and S.T.A.R. Labs Missions, Ad - hoc and Wi - Fi multiplayer, collectible hero cards, and all DLC released to date.

I really wish you'd had a better DLC marketing model that would have sustained your interest in MAG, but you kept giving things away for free and then released new game modes into a game where maps are tied to game modes, then didn't fix them when there were design issues with the flow of action.

Call of Duty: Ghosts introduces Extinction - an all - new 1 - 4 player cooperative game mode featuring a unique blend of fast - paced survival action, FPS base defence, scavenging and class levelling.

More action awaits the brave heroes of Olyndale as they slash their way through hordes of enemies, level up, and tackle randomized and instanced dungeons in the new nightmare mode together with their allies or alone.»

Sports — NBA Playgrounds 2 takes the over-the-top, two - on - two streetball action to the next level with a new line - up of online and local multiplayer game modes, as well as new courts from playgrounds across the world.

In addition to the bevy of vivid, detailed high - definition graphics that made this newest entry in the Shantae series a fan - favorite, the Ultimate Edition includes even more modes, monsters, and platforming action!

And this new portable version of the top - selling action game even contains some added features, such as new playable characters, the ability to switch between characters on the battlefield, new stages and a fun new mode that lets players level up their own fairy.

With all of this expansion for game, it is hard to say what actions they might take toward Epic Games» new Fortnite mode.

The new Toy Box mode includes a number of improvements that will likely make it possible for even the youngest gamers to get in on the action.

Set in the heat of the legendary Battle of Reach, the three new warfronts — Condemned, Highlands and Unearthed — are primed for non-stop action in Firefight and all competitive multiplayer modes.

Deeper Multiplayer Action — With six brand - new Titans, a host of deadly new Pilot abilities, an expanded customization system, new modes and much more, Titanfall 2 gives players the deeper Multiplayer experience they have been asking for.

The troubled crowdfunded spiritual successor to Mega Man, Mighty No. 9, has received a new action packed trailer showcasing many of the game play elements and revealing it's boss rush mode.

Who it's not for: While Infinite Warfare introduces some neat new mechanics and has a cool sci - fi setting, you're still pretty much getting the same movie-esque campaign, co-op zombies mode and frenetic competitive action as any other Call of Duty game.

Mysteries and challenges await in Rise of Iron including: an all - new setting on Earth called «The Plaguelands,» a twisted, dangerous, and action - packed area that has been quarantined for centuries; a brand - new six - player Raid; Felwinter Peak, a new social space where players must ascend a snowy, mountain top to reclaim a Guardian stronghold from the enemy; cooperative three - player Strikes; more quests, weapons, gear; a new competitive multiplayer mode called Supremacy and four new PvP maps; a Light level increase to 385; a new mutated enemy faction of the Fallen, and more.

This new version of Tetris Party will thrill both old - time Tetris fans and newcomers to the genre, as more than 20 modes, online battles and local multiplayer action have been squeezed into this fun - packed game.

The game became the industry's fastest - selling new IP in its first week — a record that still stands in all western European territories combined — by delivering a potent combination of action - adventure missions, seamless multiplayer modes and open - world exploration.