The phages infiltrate bacterial cells, where they commandeer the host machinery to make thousands of
new phages; then they escape through the bacterial cell wall — killing the host — and spread to infect their next victims.
New phages multiply inside and eventually burst through the bacterium, killing it.
Not exact matches
Patients in danger of dying from uncontrollable bacterial infections could find
new allies: killer viruses known as
phages.
«This suggests that
phage may contribute to urinary health and is an exciting
new avenue for future research,» said Dr. Putonti.
«We're taking advantage of what
phage have «learned» during this period for us to identify
new antibiotic targets that we believe will escape the problem of resistance found for other antibiotics.»
Research focused on the utilisation of viruses that infect and kill bacteria, known as bacteriophages or
phages, in preventing infectious diseases has gained
new traction after bacterial resistance to antibiotics has become a global problem.
This releases a
new generation of
phages.
Phages would require a less traditional approach to get official approval, such as the annual process for influenza vaccines in which manufacturers secure approval of
new formulas based on the flu bug that is going around that year, instead of conducting big clinical trials every time.
USDAs
new research on
phages to disinfect fruits and vegetables already shows great promise, Leverentz says.
The findings mean that drugs that target
phages could offer a potential
new path to mitigate antibiotic resistance.
Timed with the hundredth anniversary of their discovery, a
new review published in the British Journal of Pharmacology examines the challenges and opportunities of developing
phages as health - promoting, commercially - viable biopharmaceuticals.
Another student who was using
phage - display technology to identify
new molecular markers in ovarian cancer attended a clinic in gynecologic oncology once a week throughout her dissertation research.
A
new technique of direct binding of radioactive DNA was used to screen a complementary DNA expression library from the BJAB cell line in lambda gt11
phage to derive molecular cDNA clones representing a putative B lymphocyte - specific octamer binding protein.
They also noticed that the
new virus, named Bacillus
phage Tsamsa, is unusually large, with a giant head, a long tail and a large genome, placing it among the largest known bacteriophages.
These diseases, which include Crohn's disease and ulcerative colitis, also involve a breakdown in the mucus lining of the gut, he says, and this
new study suggests that a failure in
phage - based immunity might be the link between those symptoms.
In the 1950s, a
new, highly virulent strain of S. aureus, known as
phage type 80/81, spread worldwide, causing sepsis, skin lesions, and pneumonia.
Using this
new method, however, the scientists were able to simply reprogram such integrative
phages so that they become interesting again for antibacterial applications.
And even if there were any, for example due to a bacterium changing its surface structures to prevent the virus from attaching, the
new technology makes it possible to develop a suitable
phage against which a bacterium has not yet developed resistance.
Deep sequencing of the VHH
phage libraries generated from a set of llamas, which received two different immunization protocols, showed that the
new VHH and the previously described anti-HIV VHH J3 [26] were induced by immunization (Table 1).
A
new technique allows researchers to examine pieces of often - overlooked DNA outside bacterial chromosomes, including viruses known as
phages (as shown above), which may play a role in disease.
Also presented are possible alternative approaches to tackling infections, such as
phages (viruses that kill bacteria) sourcing
new antibiotic leads from oceans, soils and host - associated microbiomes in humans, komodo dragons and leafcutter ants.