However, measuring
NfL levels could be an added way to assess disease progression in HD clinical studies.
The more «advanced» disease group a person was in, the higher
their NfL levels, and NfL increased over time in people with the HD gene.
So not only were
NfL levels associated with severity, they could predict whether a person might become ill soon.
This means that
NfL levels were a good indicator of brain health and HD progression.
If the observations about blood / CSF
NfL levels and HD hold up under further scrutiny, we may have a useful biomarker on our hands.
Not exact matches
I think last year was all about figuring out if Trubisky has an
nfl skill set physically and if the accuracy he showed in college would carry over to the next
level.
What's more, the
level of
NfL in the blood reflected the amount found in the CSF, the fluid bathing the brain.
If a person had a high
level of
NfL at the beginning of the study but no symptoms, they often began to develop symptoms during the study.
Importantly, the highest
levels of
NfL corresponded with more damage to the brain and poorer scores on movement and reasoning tests.
It will be particularly interesting to see whether current or future treatments can lower
levels of
NfL, mirroring improvements in symptoms.
This led Wild and his team to hypothesize that increasing damage to the brain areas affected by HD would cause higher
levels of
NfL to accumulate in the blood.