Sentences with phrase «normal cell damage»

Not exact matches

But in the lab, when the scientists manipulated human cells to be able to create the water bear shielding protein — called Dsup — they showed about half the DNA damage as normal cells.

The antioxidants in AppleActiv play an important role in neutralizing oxidative damage caused by free radicals, repairing damage and protecting the normal functioning of cells and tissues.

The oxidative damage caused to normal cells by free radicals has been linked to chronic conditions like cancer, heart disease, and degenerative diseases related to aging.

Carcinogens may cause cancer by altering cellular metabolism or damaging DNA directly in cells, which interferes with normal biological processes.

Damaged mouse sciatic nerves produced hundreds of times the normal amount of two «chemoattractant» molecules, Cxcl1 and Cxcl2, which attach to the surfaces of neutrophils and draw the immune cells into injured tissue.

The study found that carfilzomib and irinotecan have a potential synergistic effect in SCLC and other Irinotecan - sensitive cancers by allowing normal DNA damage repair and enabling normal cell - cycle death.

The goal of stem cell therapy is to replace the damaged tissue with new heart cells and restore the failing heart to normal function.

«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»

In multiple myeloma, normal plasma cells transform into malignant myeloma cells and produce large quantities of toxic abnormal immunoglobulin called monoclonal protein that can damage multiple organs.

Since cancer cells divide more often than most normal cells, they react more sensitive to DNA damaging agents.

Unlike normal cells, however, the tumour cells are considerably more sensitive, because they can not repair damage well.

«Blocking the damage response in normal cells that have been bathed in chemotherapy could be instrumental in keeping errant or dormant cancer cells from starting down the path to proliferation,» he said.

Being obese or having a higher body mass index (BMI) while carrying a BRCA (BReast CAncer gene) mutation is positively linked with higher levels of damage to the DNA in normal breast gland cells, new research suggests.

The pluripotent stem cell - derived muscle fibers develop reservoirs of «satellite - like cells» that are necessary for normal adult muscles to repair damage, while the muscle from the previous study had much fewer of these cells.

The researchers found that mutant mice lacking Del - 1 had more severe attacks of the EAE than normal mice, with more damage to myelin, the fatty sheath that coats neurons and helps in the transmission of signals along the cell.

The off - target antibodies and overdose usage of antibodies can cause side effects such as an autoimmune disorder, which can damage normal tissue cells.»

This revealed telomeres as dangerous structures during mitosis, because the cells momentarily lost the ability to distinguish between damaged DNA strands and normal telomeres.

Would all this carefully targeted weaponry that destroys cancer cells without inflicting collateral damage on normal tissue work on cancers outside the brain?

In a bid to progress beyond the shotgun approach to fighting cancer — blasting malignant cells with toxic chemicals or radiation, which kills surrounding healthy cells in the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal tissue.

Our body has a system to repair DNA damage (DNA repair mechanism), so why a normal cell turns into a cancer cell and why radiation exposure causes cancer have not been clarified.

For example, BIC lasers can be readily tuned to emit beams of different wavelengths, a useful feature for medical lasers made to precisely target cancer cells without damaging normal tissue.

Autophagy, Roepe explains, is the process by which cells remove damaged parts of themselves to restore normal function.

The Stanford researchers, who report their results in the current issue of the Journal of Experimental Medicine, used a clever trick to shut off this damaging immune response: They engineered TH1 cells to produce IL - 4 instead of their normal cytokines.

«Autophagy,» which means «self - eating» based on its Greek roots, is the normal physiological process the body's cells use to remove viruses, bacteria, and damaged material from the cell.

Some researchers consider normal aging to be a disease, where our cells accumulate damage over time.

Based on years of scientific research into the root causes of the condition, the device uses precisely timed sounds and weak electrical pulses that activate touch - sensitive nerves, both aimed at steering damaged nerve cells back to normal activity.

Comparing the damaged sites in normal cells before and after infection with H. pylori revealed that genes located close to the margins of the chromosomes, the so - called sub-telomeric regions, are more likely to be damaged after infection, as are genes that are active in gastric cells.

In 2001, he discovered that a strain of yeast made up of unusually small cells and colonies lived about three times longer than normal yeast and was highly protected from DNA damage and aging.

But while analyzing the liver cells of two of his patients, Laron found that normal growth hormone failed to bind to its associated receptor, suggesting that the receptors were damaged.

«Oxygen by - products produced during normal metabolism can cause oxidative damage to biomolecules in cells, such as DNA and RNA,» explains Jian - Ping Cai, a researcher involved in the study.

People who have chronic inflammation because of chronic infection, autoimmune disease or conditions such as obesity have a higher cancer risk because of damage to normal cells.

The challenge for the future now lies in finding a suitable type of «grit» for this black ice that slows down the proliferation of leukemia cells to normal levels without damaging the other healthy cells in the body.

They found that the cancer cells were more sensitive to DNA damage than normal cells.

When normal, EMSY, BRCA1 and BRCA2 give the body's cells instructions to create proteins that help to repair DNA damage that can cause cancer.

«Chemotherapy is applied in one cycle then stopped to allow your bone marrow and normal stem cells to recover from the damage, and then another cycle starts again,» he said.

While reactive oxygen species (ROS), can damage and kill cells — these molecules have also been implicated in normal biochemical processes.

Free radicals are highly damaging by - products of normal cell chemistry.

«The cancer stem cells actively regrow and respond to the induced damage or apoptosis (cell death) caused by chemotherapy in between the different cycles, similar to how normal tissue stem cells respond to wound - induced damages.»

Their studies revealed that a subset of normal breast precursor cells, called luminal progenitors, have dangerously short telomeres and display a correspondingly high level DNA damage response localized at their chromosome ends.

A-T is caused by lost function in a gene, ATM, which normally repairs damaged DNA in the cells and preserves normal function.

And it was buttressed by evidence that the normal metabolic consumption of energy generates reactive molecules called free radicals that damage DNA, enzymes, and cell membranes.

These treatments target any rapidly dividing cells (not necessarily just cancer cells), but normal cells usually can recover from any chemical - induced damage while cancer cells can not.

EFTF - expressing pluripotent cells form functional retinal cells and eyes when transplanted to the developing embryo, but can these induced retinal cells also differentiate into all the functional retinal cell classes in a mature normal or damaged retinal environment?

Unlike traditional chemotherapy, these drugs limit damage to normal cells.

DNA damaging agents can promote ageing, disease and cancer and are widespread in the environment as well as being produced within human cells as normal cellular metabolites

Clarke notes that this kind of work — reprogramming normal cells to replace damaged tissues or organs in regenerative medicine, or even growing cells from an individual's cancer to determine what the best treatment is — speaks to the doctrine rather than challenges it.

«This study is a proof - of - principle that drugs of this chemical type cause energy stress and lower ATP levels to where it kills LKB1 - deficient cells without damaging normal, healthy cells,» says Shaw, senior author of the study.

In normal conditions, microglial cells do not make APOE; however, in disease conditions, they sense the brain damage and respond by churning out APOE.

LA JOLLA, CA — Rapidly dividing cancer cells are skilled at patching up damage that would stop normal cells in their tracks, including wear and tear of telomeres, the protective caps at the end of each chromosome.

The proteins and other constituents of our cells are all eventually damaged as the result of biochemical accidents that occur during normal metabolism, or simply outlive their usefulness.